ID   BRCA2_DROSI             Reviewed;         944 AA.
AC   B4QC10;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Breast cancer type 2 susceptibility protein homolog {ECO:0000250|UniProtKB:Q9W157};
GN   Name=Brca2 {ECO:0000250|UniProtKB:Q9W157}; ORFNames=GD11868;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1] {ECO:0000312|EMBL:EDX08565.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Involved in and required for double-strand break repair by
CC       meiotic and mitotic homologous recombination. During meiosis, has a
CC       dual role in the repair of meiotic double-stranded breaks and the
CC       efficient activation of the meiotic recombination checkpoint (By
CC       similarity). {ECO:0000250|UniProtKB:Q9W157}.
CC   -!- SUBUNIT: Interacts with Rad9 and spn-A/Rad51.
CC       {ECO:0000250|UniProtKB:Q9W157}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9W157}.
CC       Note=Brca2 and spn-A become recruited to nuclear foci after DNA damage.
CC       {ECO:0000250|UniProtKB:Q9W157}.
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DR   EMBL; CM000362; EDX08565.1; -; Genomic_DNA.
DR   AlphaFoldDB; B4QC10; -.
DR   STRING; 7240.B4QC10; -.
DR   PRIDE; B4QC10; -.
DR   HOGENOM; CLU_315529_0_0_1; -.
DR   OMA; ECFSEDM; -.
DR   PhylomeDB; B4QC10; -.
DR   Proteomes; UP000000304; Chromosome 2r.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0043150; P:DNA synthesis involved in double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   GO; GO:0010778; P:meiotic DNA repair synthesis involved in reciprocal meiotic recombination; ISS:UniProtKB.
DR   GO; GO:0051598; P:meiotic recombination checkpoint signaling; ISS:UniProtKB.
DR   GO; GO:1901563; P:response to camptothecin; IEA:EnsemblMetazoa.
DR   InterPro; IPR002093; BRCA2_repeat.
DR   PROSITE; PS50138; BRCA2_REPEAT; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; DNA damage; DNA repair; Meiosis; Mitosis;
KW   Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..944
FT                   /note="Breast cancer type 2 susceptibility protein homolog"
FT                   /id="PRO_0000392918"
FT   REPEAT          543..577
FT                   /note="BRCA2 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          644..678
FT                   /note="BRCA2 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          719..753
FT                   /note="BRCA2 3"
FT                   /evidence="ECO:0000255"
FT   REGION          325..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          415..440
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          823..854
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          876..944
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        415..433
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        829..854
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        877..905
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        906..920
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   944 AA;  105728 MW;  9EB1D975425AA798 CRC64;
     MDQNGASGSR PNRLSQGKEA YACERSATVS AAADRSNIIN EMAKICEADR QTSAIARRTQ
     VHERLAVANS DFVAVEDLIL AYAEPTPEDQ VEMIMRDFCS SPTYEEDEDE PSYESEPWFR
     FRNKRIRTYS RKRDPKSYMA VRTEKSSGTS GLSVQRDLNT SSTSVACDFD AASSQKIHEV
     LLNLSQYFSA TAKASSPTPV PSQIDLPTEA RQDSGDECFN AEVENLRDDL LQNGFTFEAS
     IYDNEHEQED SGKFNVCSDA DSTPKKTDVE IAEHKKHLKG PTQAEHVGKE ENTNFILEGI
     PLSEWLTPME PPKISKDVIK NIPDKKVKLE PSSQKEQKSS KDSNESKIRA ASCDITKKNE
     GTTVLDQPNA AQQENLSNDG DLLEEFLFNE WHPMQCSNGP STSNDAIKVP KEEINSIKRN
     DEEQPEKETP NKSRSTSSHQ LSFRKTFLKF IEISGEMKIK GEKFVEKVVS GLHHPSHKCN
     LRTEEYSDNH SQVMESTQRV EFKSALSKPI ELLDEKETYD MLAKVEVGEI NGKCSPLNNE
     TIAEPEFCGF RTASNKAIPI SEKMKIKTAE FMAEFQSKET NHQNDYLVNQ PNDNSTSVGR
     DTAFKKSIEI SEEMPTKASK LVVVDTTLGE PHQPKIDPVC SDLNESQFFG FRTASNKAIE
     ITEAMEKRGA MFLAQSRATD QQAEWQPSDF PDIPHTSPKN EIHSINVENT KAVHTKTASE
     TEFFGFRTAS NKGIVISENT KKKVAQFMSE FQAADASTDS NKPIVISEES RNIAAKFVDE
     AATEDSPNKP TFCNVQSQEN PLDIEHFKHD LFVERSAKEE HPLCSQPLVR TPRRSQEIHS
     SLSQLAGQSP LDQATKKSVI ARRNLLSLKR KRKIVSSTET STSCASPAME RFAPKPSSTS
     TPLADRDLNR SKDCAKNRQD AEDMSPICMQ PKKSRRLGLS RSRY