ID   TETS_LISMN              Reviewed;         641 AA.
AC   Q48791;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Tetracycline resistance protein TetS;
DE            Short=Tet(S);
GN   Name=tetS; Synonyms=tet(S);
OS   Listeria monocytogenes.
OG   Plasmid pIP811.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=1639;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BM4210;
RX   PubMed=8370538; DOI=10.1016/0378-1119(93)90665-p;
RA   Charpentier E., Gerbaud G., Courvalin P.;
RT   "Characterization of a new class of tetracycline-resistance gene tet(S) in
RT   Listeria monocytogenes BM4210.";
RL   Gene 131:27-34(1993).
CC   -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC       synthesis by a non-covalent modification of the ribosomes.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. TetM/TetO
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01059}.
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DR   EMBL; L09756; AAA25293.1; -; Genomic_DNA.
DR   PIR; JN0800; JN0800.
DR   RefSeq; WP_000691722.1; NG_048273.1.
DR   AlphaFoldDB; Q48791; -.
DR   SMR; Q48791; -.
DR   GeneID; 66817191; -.
DR   KEGG; ag:AAA25293; -.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR   CDD; cd03711; Tet_C; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR041095; EFG_II.
DR   InterPro; IPR035647; EFG_III/V.
DR   InterPro; IPR000640; EFG_V-like.
DR   InterPro; IPR031157; G_TR_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR035650; Tet_C.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR   Pfam; PF00679; EFG_C; 1.
DR   Pfam; PF14492; EFG_III; 1.
DR   Pfam; PF03764; EFG_IV; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SMART; SM00838; EFG_C; 1.
DR   SMART; SM00889; EFG_IV; 1.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF54980; SSF54980; 2.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS00301; G_TR_1; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; GTP-binding; Nucleotide-binding; Plasmid;
KW   Protein biosynthesis.
FT   CHAIN           1..641
FT                   /note="Tetracycline resistance protein TetS"
FT                   /id="PRO_0000091515"
FT   DOMAIN          1..242
FT                   /note="tr-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01059"
FT   BINDING         10..17
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         74..78
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         128..131
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   641 AA;  73014 MW;  EC534FD38FD54FC2 CRC64;
     MKIINIGILA HVDAGKTTLT ESLLYSSGAI KELGSVDSGT TKTDTMFLER QRGITIQTAI
     TSFQRENVKV NIVDTPGHMD FLADVYRSLS VLDGAILLIS AKDGVQSQTR ILFHALRKMN
     IPIIFFINKI DQNGINLPDV YQDIKDKLSD DIIIKQTVNL NLKPYVIDYT EPEQWETVIV
     GNDYLLEKYT IGKTLNIAEL EKEENERIQS CSLYPVYHGS AKNNIGIKQL IEVITSKLFS
     PTQLNSDKLC GNVFKVEYSD DGQRLVYVRL YSGTLHLRDS VNISEKEKIK VTEMYTSING
     ELRQIDKAEP GEIIILKNEL LKLNNVLGDK KRLPHREILE NPLPMLQTTI EPCKSVQREK
     LLDALFEISD SDPLLQYYVD TVTHEIVLSF LGEVQMEVTC TLIQEKYHIE IETRKPTVIY
     MERPLKKSEF TIDIEVPPNP FWASIGLSVT PLPLGSGIQY ESLVSLGYLN QSFQNAVMEG
     IRYGCEQGLY GWKLTDCKIC FKYGLYYSPV STPADFRMLA PIVLEQAFRK SGTELLEPYL
     SFEIYVPQEY LSRAYNDASK YCANILNTKL KGNEVILIGE IPARCIQEYR NSLTFFTNGR
     SVCLTELKGY QVTNIKSAFQ PRRPNNRIDK VRHMFNKINL H