ID   TETW_BUTFI              Reviewed;         639 AA.
AC   O52836;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Tetracycline resistance protein TetW;
DE            Short=Tet(W);
GN   Name=tetW; Synonyms=tet(W);
OS   Butyrivibrio fibrisolvens.
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Butyrivibrio.
OX   NCBI_TaxID=831;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1.230;
RX   PubMed=9292992; DOI=10.1128/aem.63.9.3405-3411.1997;
RA   Scott K.P., Barbosa T.M., Forbes K.J., Flint H.J.;
RT   "High-frequency transfer of a naturally occurring chromosomal tetracycline
RT   resistance element in the ruminal anaerobe Butyrivibrio fibrisolvens.";
RL   Appl. Environ. Microbiol. 63:3405-3411(1997).
CC   -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC       synthesis by a non-covalent modification of the ribosomes.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. TetM/TetO
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01059}.
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DR   EMBL; AJ222769; CAA10975.1; -; Genomic_DNA.
DR   RefSeq; WP_002586627.1; NG_048281.1.
DR   AlphaFoldDB; O52836; -.
DR   SMR; O52836; -.
DR   GeneID; 64114426; -.
DR   KEGG; ag:CAA10975; -.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR   CDD; cd03711; Tet_C; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR041095; EFG_II.
DR   InterPro; IPR035647; EFG_III/V.
DR   InterPro; IPR000640; EFG_V-like.
DR   InterPro; IPR031157; G_TR_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR035650; Tet_C.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR   Pfam; PF00679; EFG_C; 1.
DR   Pfam; PF14492; EFG_III; 1.
DR   Pfam; PF03764; EFG_IV; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SMART; SM00889; EFG_IV; 1.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF54980; SSF54980; 2.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS00301; G_TR_1; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; GTP-binding; Nucleotide-binding;
KW   Protein biosynthesis.
FT   CHAIN           1..639
FT                   /note="Tetracycline resistance protein TetW"
FT                   /id="PRO_0000091516"
FT   DOMAIN          1..243
FT                   /note="tr-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01059"
FT   BINDING         10..17
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         74..78
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         128..131
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   639 AA;  71295 MW;  9043F095B9CF38B5 CRC64;
     MKIINIGILA HVDAGKTTLT ESLLYASGAI SEPGSVEKGT TRTDTMFLER QRGITIQAAV
     TSFQWHRCKV NIVDTPGHMD FLAEVYRSLA VLDGAILVIS AKDGVQAQTR ILFHALRKMN
     IPTVIFINKI DQAGVDLQSV VQSVRDKLSA DIIIKQTVSL SPEIVLEENT DIEAWDAVIE
     NNDELLEKYI AGEPISREKL AREEQQRVQD ASLFPVYHGS AKNGLGIQPL MDAVTGLFQP
     IGEQGGAALC GSVFKVEYTD CGQRRVYLRL YSGTLRLRDT VALAGREKLK ITEMRIPSKG
     EIVRTDTAYQ GEIVILPSDS VRLNDVLGDQ TRLPRKRWRE DPLPMLRTTI APKTAAQRER
     LLDALTQLAD TDPLLRCEVD SITHEIILSF LGRVQLEVVS ALLSEKYKLE TVVKEPSVIY
     MERPLKAASH TIHIEVPPNP FWASIGLSVT PLSLGSGVQY ESRVSLGYLN QSFQNAVRDG
     IRYGLEQGLF GWNVTDCKIC FEYGLYYSPV STPADFRSLA PIVLEQALKE SGTQLLEPYL
     SFILYAPQEY LSRAYHDAPK YCATIETAQV KKDEVVFTGE IPARCIQAYR TDLAFYTNGR
     SVCLTELKGY QAAVGQPVIQ PRRPNSRLDK VRHMFQKVM