ID   TEV2_BPT4               Reviewed;         258 AA.
AC   P07072; Q9G0D7;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   19-DEC-2001, sequence version 2.
DT   12-AUG-2020, entry version 82.
DE   RecName: Full=Intron-associated endonuclease 2;
DE            EC=3.1.-.-;
DE   AltName: Full=I-TevII;
GN   Name=ITEVIIR;
OS   Enterobacteria phage T4 (Bacteriophage T4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Myoviridae; Tevenvirinae; Tequatrovirus.
OX   NCBI_TaxID=10665;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C;
RX   PubMed=3575111; DOI=10.1093/nar/15.8.3632;
RA   Tomaschewski J., Rueger W.;
RT   "Nucleotide sequence and primary structures of gene products coded for by
RT   the T4 genome between map positions 48.266 kb and 39.166 kb.";
RL   Nucleic Acids Res. 15:3632-3633(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12626685; DOI=10.1128/mmbr.67.1.86-156.2003;
RA   Miller E.S., Kutter E., Mosig G., Arisaka F., Kunisawa T., Ruger W.;
RT   "Bacteriophage T4 genome.";
RL   Microbiol. Mol. Biol. Rev. 67:86-156(2003).
CC   -!- FUNCTION: This endonuclease is specific to the nrdD gene splice
CC       junction and is involved in intron homing.
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DR   EMBL; Y00122; CAA68309.1; -; Genomic_DNA.
DR   EMBL; AF158101; AAD42522.2; -; Genomic_DNA.
DR   PIR; D29284; Z5BPT9.
DR   RefSeq; NP_049691.2; NC_000866.4.
DR   SMR; P07072; -.
DR   REBASE; 2624; I-TevII.
DR   GeneID; 1258800; -.
DR   KEGG; vg:1258800; -.
DR   Proteomes; UP000009087; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006314; P:intron homing; IEA:UniProtKB-KW.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR003647; Intron_nuc_1_rpt.
DR   InterPro; IPR003611; NUMOD3.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00497; IENR1; 1.
DR   SMART; SM00496; IENR2; 2.
DR   PROSITE; PS50164; GIY_YIG; 1.
PE   4: Predicted;
KW   Endonuclease; Hydrolase; Intron homing; Nuclease; Reference proteome.
FT   CHAIN           1..258
FT                   /note="Intron-associated endonuclease 2"
FT                   /id="PRO_0000192793"
FT   DOMAIN          14..96
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00977"
FT   CONFLICT        81
FT                   /note="H -> D (in Ref. 1; CAA68309)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   258 AA;  30389 MW;  6BD6918C4EA34F99 CRC64;
     MKWKLRKSLK IANSVAFTYM VRFPDKSFYI GFKKFKTIYG KDTNWKEYNS SSKLVKEKLK
     DYKAKWIILQ VFDSYESALK HEEMLIRKYF NNEFILNKSI GGYKFNKYPD SEEHKQKLSN
     AHKGKILSLK HKDKIREKLI EHYKNNSRSE AHVKNNIGSR TAKKTVSIAL KSGNKFRSFK
     SAAKFLKCSE EQVSNHPNVI DIKITIHPVP EYVKINDNIY KSFVDAAKDL KLHPSRIKDL
     CLDDNYPNYI VSYKRVEK