ID   TEX10_DANRE             Reviewed;         933 AA.
AC   Q803M3; Q6PUR4;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 2.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Testis-expressed protein 10 homolog;
GN   Name=tex10; ORFNames=zgc:55523;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the PELP1 complex involved in the nucleolar
CC       steps of 28S rRNA maturation and the subsequent nucleoplasmic transit
CC       of the pre-60S ribosomal subunit. {ECO:0000250|UniProtKB:Q9NXF1}.
CC   -!- SUBUNIT: Component of some MLL1/MLL complex. Component of the PELP1
CC       complex, composed of at least pelp1, tex10 and wdr18. The complex
CC       interacts with pre-60S ribosome particles.
CC       {ECO:0000250|UniProtKB:Q9NXF1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:Q3URQ0}. Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9NXF1}.
CC   -!- SIMILARITY: Belongs to the IPI1/TEX10 family. {ECO:0000305}.
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DR   EMBL; AY577001; AAS92639.1; -; mRNA.
DR   EMBL; BC044417; AAH44417.1; -; mRNA.
DR   RefSeq; NP_997870.1; NM_212705.1.
DR   AlphaFoldDB; Q803M3; -.
DR   STRING; 7955.ENSDARP00000072745; -.
DR   PaxDb; Q803M3; -.
DR   PRIDE; Q803M3; -.
DR   GeneID; 327196; -.
DR   KEGG; dre:327196; -.
DR   CTD; 54881; -.
DR   ZFIN; ZDB-GENE-040426-2827; tex10.
DR   eggNOG; KOG2149; Eukaryota.
DR   InParanoid; Q803M3; -.
DR   OrthoDB; 1285836at2759; -.
DR   PhylomeDB; Q803M3; -.
DR   Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q803M3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0071339; C:MLL1 complex; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024679; Ipi1_N.
DR   InterPro; IPR037947; TEX10/Ipi1.
DR   PANTHER; PTHR16056:SF2; PTHR16056:SF2; 1.
DR   Pfam; PF12333; Ipi1_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..933
FT                   /note="Testis-expressed protein 10 homolog"
FT                   /id="PRO_0000072489"
FT   REPEAT          99..137
FT                   /note="HEAT"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        388
FT                   /note="N -> Y (in Ref. 2; AAH44417)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        685
FT                   /note="K -> E (in Ref. 2; AAH44417)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        835
FT                   /note="F -> L (in Ref. 2; AAH44417)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        910
FT                   /note="I -> T (in Ref. 2; AAH44417)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   933 AA;  104018 MW;  8E5E2BD6234FA1EF CRC64;
     MSKKRKRQDD FQKTKLKVGK KKPKADNATN VNFRSKSIHL PEQLKHGESG PTTHRHLDIK
     DLLSQLHHFN SNVKQGALVG LRELLSANPT MVELHASVVL SEVAALFTDK DGSVRAAAVR
     LLRFVAQCIP SERVAPFFPL LSAHLTCAMT HISEAIQEEA LRVLDVLLEH YPGLLSQRHT
     VLLGNFLELI SQRRKSGTGQ DKSGKGSYAL TVTTNRSVTA QQWRLTVLLR LSNFLQAVVE
     ERPLEEGVSS RIGLGMWAVE KGLVTPVDVT WEEHVNGQGK IQLFENSGAG PTSHSAYRLR
     PDSKSGAGMD KELCSAETVQ GFAATLVPLL LEIWVEAAGG GRVQTDSGHL LSAESMALMF
     QILSILQLLR RMTPQRDQQD VLDAWFRNSY LTDFKQHFMK NFPYGLLEVA RHKKKADGKR
     IKQPVAAGVV AGSTVEPLAV NVTLCQVMVT LSLRGQDHVA AEDADWLGPI RVFIRETLSN
     GSKLSSKHLA ALLEVVWRMI VTQRSRVVTD ELLQAVYVQY QQRNLSVNVR SLLLRFFSQL
     YIQEHQNHPH IARSRILARW LASLPVQLVQ LGSRNPQLSA QLLETVQPAA ARGNKDLLQS
     LQKNACSLYD PQEGCVVVLP VESQKRLVQI LHFLPEFPAE LLACLSEVCN TGRVSASLAT
     TLIRTVHLRS PLSGCSSASQ DVPLKDVDYL SFFFTTLTGF SSDMLRALQD KDEDDLLAAS
     TLSPLSVYTT SLDQFLHHWD VVEVVCHCLD TLGSRAQCFD VIQNAIINNL AGLVVVPDCV
     CVALLRCVPR LLDVNFLPSD TLLHFLSDCC LSMLSLLLQL EQSARKRDAV WEACFAALSS
     VPRLLRLVLQ SFRVLDLCED ELPVLAQILS LLLQHTQLRN HMMANASFLQ HIIQDLTHYY
     GGESREQWLI DLLYCYSVTL STHRANMGIR DIY