TEX10_HUMAN
ID TEX10_HUMAN Reviewed; 929 AA.
AC Q9NXF1; B4DYV2; Q5T722; Q5T723; Q8NCN8; Q8TDY0;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=Testis-expressed protein 10;
GN Name=TEX10; ORFNames=L18, Nbla10363;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=15334068; DOI=10.1038/sj.onc.1207921;
RA Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C.,
RA Cerveny C., Law C.-L., Wahl A., Carter P.;
RT "Suppression subtractive hybridization and expression profiling identifies
RT a unique set of genes overexpressed in non-small-cell lung cancer.";
RL Oncogene 23:7734-7745(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Neuroblastoma;
RX PubMed=12880961; DOI=10.1016/s0304-3835(03)00085-5;
RA Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S.,
RA Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S.,
RA Hirato J., Nakagawara A.;
RT "Neuroblastoma oligo-capping cDNA project: toward the understanding of the
RT genesis and biology of neuroblastoma.";
RL Cancer Lett. 197:63-68(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Hepatoma, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=12429849; DOI=10.1091/mbc.e02-05-0271;
RA Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C.,
RA Greco A., Hochstrasser D.F., Diaz J.-J.;
RT "Functional proteomic analysis of human nucleolus.";
RL Mol. Biol. Cell 13:4100-4109(2002).
RN [7]
RP IDENTIFICATION IN THE MLL1/MLL COMPLEX.
RX PubMed=15960975; DOI=10.1016/j.cell.2005.04.031;
RA Dou Y., Milne T.A., Tackett A.J., Smith E.R., Fukuda A., Wysocka J.,
RA Allis C.D., Chait B.T., Hess J.L., Roeder R.G.;
RT "Physical association and coordinate function of the H3 K4
RT methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.";
RL Cell 121:873-885(2005).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=16964243; DOI=10.1038/nbt1240;
RA Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
RT "A probability-based approach for high-throughput protein phosphorylation
RT analysis and site localization.";
RL Nat. Biotechnol. 24:1285-1292(2006).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-29, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [13]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [14]
RP IDENTIFICATION IN THE PELP1 COMPLEX, AND SUBCELLULAR LOCATION.
RX PubMed=21326211; DOI=10.1038/emboj.2011.33;
RA Finkbeiner E., Haindl M., Muller S.;
RT "The SUMO system controls nucleolar partitioning of a novel mammalian
RT ribosome biogenesis complex.";
RL EMBO J. 30:1067-1078(2011).
RN [15]
RP FUNCTION, AND IDENTIFICATION IN THE 5FMC COMPLEX.
RX PubMed=22872859; DOI=10.1074/mcp.m112.017194;
RA Fanis P., Gillemans N., Aghajanirefah A., Pourfarzad F., Demmers J.,
RA Esteghamat F., Vadlamudi R.K., Grosveld F., Philipsen S., van Dijk T.B.;
RT "Five friends of methylated chromatin target of protein-arginine-
RT methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation
RT to desumoylation.";
RL Mol. Cell. Proteomics 11:1263-1273(2012).
RN [16]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-29, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Functions as a component of the Five Friends of Methylated
CC CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by
CC methylated CHTOP, leading to desumoylation of ZNF148 and subsequent
CC transactivation of ZNF148 target genes (PubMed:22872859). Component of
CC the PELP1 complex involved in the nucleolar steps of 28S rRNA
CC maturation and the subsequent nucleoplasmic transit of the pre-60S
CC ribosomal subunit (PubMed:21326211). {ECO:0000269|PubMed:21326211,
CC ECO:0000269|PubMed:22872859}.
CC -!- SUBUNIT: Component of some MLL1/MLL complex, at least composed of the
CC core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well
CC as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1,
CC LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2,
CC RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and
CC TEX10. Component of the 5FMC complex, at least composed of PELP1,
CC LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated
CC CHTOP and ZNF148. Component of the PELP1 complex, composed of at least
CC PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome
CC particles (PubMed:21326211). {ECO:0000269|PubMed:15960975,
CC ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}.
CC -!- INTERACTION:
CC Q9NXF1; Q9H4L4: SENP3; NbExp=2; IntAct=EBI-2371062, EBI-2880236;
CC Q9NXF1; Q9BV38: WDR18; NbExp=2; IntAct=EBI-2371062, EBI-727429;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC {ECO:0000250|UniProtKB:Q3URQ0}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q3URQ0}. Nucleus, nucleolus
CC {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:21326211}. Note=Mainly
CC found in the nucleoplasm, with low levels detected in the cytoplasmic
CC and chromatin fractions. {ECO:0000250|UniProtKB:Q3URQ0}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NXF1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NXF1-2; Sequence=VSP_043704, VSP_043705;
CC -!- SIMILARITY: Belongs to the IPI1/TEX10 family. {ECO:0000305}.
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DR EMBL; AY598337; AAT06748.1; -; mRNA.
DR EMBL; AB060968; BAB87845.1; -; mRNA.
DR EMBL; AK000294; BAA91062.1; -; mRNA.
DR EMBL; AK302619; BAG63864.1; -; mRNA.
DR EMBL; AL353805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL445214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC030652; AAH30652.1; -; mRNA.
DR CCDS; CCDS55330.1; -. [Q9NXF1-2]
DR CCDS; CCDS6748.1; -. [Q9NXF1-1]
DR RefSeq; NP_001155056.1; NM_001161584.1. [Q9NXF1-2]
DR RefSeq; NP_060216.2; NM_017746.3. [Q9NXF1-1]
DR AlphaFoldDB; Q9NXF1; -.
DR BioGRID; 120229; 161.
DR CORUM; Q9NXF1; -.
DR IntAct; Q9NXF1; 57.
DR MINT; Q9NXF1; -.
DR STRING; 9606.ENSP00000364037; -.
DR GlyGen; Q9NXF1; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9NXF1; -.
DR PhosphoSitePlus; Q9NXF1; -.
DR SwissPalm; Q9NXF1; -.
DR BioMuta; TEX10; -.
DR DMDM; 71153593; -.
DR SWISS-2DPAGE; Q9NXF1; -.
DR EPD; Q9NXF1; -.
DR jPOST; Q9NXF1; -.
DR MassIVE; Q9NXF1; -.
DR MaxQB; Q9NXF1; -.
DR PaxDb; Q9NXF1; -.
DR PeptideAtlas; Q9NXF1; -.
DR PRIDE; Q9NXF1; -.
DR ProteomicsDB; 83086; -. [Q9NXF1-1]
DR ProteomicsDB; 83087; -. [Q9NXF1-2]
DR Antibodypedia; 43979; 30 antibodies from 13 providers.
DR DNASU; 54881; -.
DR Ensembl; ENST00000374902.9; ENSP00000364037.4; ENSG00000136891.14. [Q9NXF1-1]
DR Ensembl; ENST00000535814.5; ENSP00000444555.1; ENSG00000136891.14. [Q9NXF1-2]
DR GeneID; 54881; -.
DR KEGG; hsa:54881; -.
DR MANE-Select; ENST00000374902.9; ENSP00000364037.4; NM_017746.4; NP_060216.2.
DR UCSC; uc004bas.4; human. [Q9NXF1-1]
DR CTD; 54881; -.
DR DisGeNET; 54881; -.
DR GeneCards; TEX10; -.
DR HGNC; HGNC:25988; TEX10.
DR HPA; ENSG00000136891; Low tissue specificity.
DR neXtProt; NX_Q9NXF1; -.
DR OpenTargets; ENSG00000136891; -.
DR PharmGKB; PA134991964; -.
DR VEuPathDB; HostDB:ENSG00000136891; -.
DR eggNOG; KOG2149; Eukaryota.
DR GeneTree; ENSGT00950000182992; -.
DR HOGENOM; CLU_014208_0_0_1; -.
DR InParanoid; Q9NXF1; -.
DR OMA; THHWDIV; -.
DR PhylomeDB; Q9NXF1; -.
DR TreeFam; TF318197; -.
DR PathwayCommons; Q9NXF1; -.
DR Reactome; R-HSA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR SignaLink; Q9NXF1; -.
DR SIGNOR; Q9NXF1; -.
DR BioGRID-ORCS; 54881; 609 hits in 1092 CRISPR screens.
DR ChiTaRS; TEX10; human.
DR GeneWiki; TEX10; -.
DR GenomeRNAi; 54881; -.
DR Pharos; Q9NXF1; Tdark.
DR PRO; PR:Q9NXF1; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q9NXF1; protein.
DR Bgee; ENSG00000136891; Expressed in ventricular zone and 171 other tissues.
DR ExpressionAtlas; Q9NXF1; baseline and differential.
DR Genevisible; Q9NXF1; HS.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0071339; C:MLL1 complex; IDA:UniProtKB.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR024679; Ipi1_N.
DR InterPro; IPR037947; TEX10/Ipi1.
DR PANTHER; PTHR16056:SF2; PTHR16056:SF2; 1.
DR Pfam; PF12333; Ipi1_N; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..929
FT /note="Testis-expressed protein 10"
FT /id="PRO_0000072491"
FT REPEAT 99..137
FT /note="HEAT"
FT MOD_RES 29
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1
FT /note="M -> MSRM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043704"
FT VAR_SEQ 822..840
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043705"
FT CONFLICT 411
FT /note="R -> G (in Ref. 5; AAH30652)"
FT /evidence="ECO:0000305"
FT CONFLICT 430
FT /note="H -> R (in Ref. 1; AAT06748 and 3; BAA91062)"
FT /evidence="ECO:0000305"
FT CONFLICT 526
FT /note="F -> L (in Ref. 5; AAH30652)"
FT /evidence="ECO:0000305"
FT CONFLICT 731
FT /note="D -> E (in Ref. 2; BAB87845)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 929 AA; 105674 MW; 2E0F8062989415BA CRC64;
MTKKRKRQHD FQKVKLKVGK KKPKLQNATP TNFKTKTIHL PEQLKEDGTL PTNNRKLNIK
DLLSQMHHYN AGVKQSALLG LKDLLSQYPF IIDAHLSNIL SEVTAVFTDK DANVRLAAVQ
LLQFLAPKIR AEQISPFFPL VSAHLSSAMT HITEGIQEDS LKVLDILLEQ YPALITGRSS
ILLKNFVELI SHQQLSKGLI NRDRSQSWIL SVNPNRRLTS QQWRLKVLVR LSKFLQALAD
GSSRLRESEG LQEQKENPHA TSNSIFINWK EHANDQQHIQ VYENGGSQPN VSSQFRLRYL
VGGLSGVDEG LSSTENLKGF IEIIIPLLIE CWVEAVPPQL ATPVGNGIER EPLQVMQQVL
NIISLLWKLS KQQDETHKLE SWLRKNYLID FKHHFMSRFP YVLKEITKHK RKEPNKSIKH
CTVLSNNIDH LLLNLTLSDI MVSLANASTL QKDCSWIEMI RKFVTETLED GSRLNSKQLN
RLLGVSWRLM QIQPNREDTE TLIKAVYTLY QQRGLILPVR TLLLKFFSKI YQTEELRSCR
FRYRSKVLSR WLAGLPLQLA HLGSRNPELS TQLIDIIHTA AARANKELLK SLQATALRIY
DPQEGAVVVL PADSQQRLVQ LVYFLPSLPA DLLSRLSRCC IMGRLSSSLA AMLIGILHMR
SSFSGWKYSA KDWLMSDVDY FSFLFSTLTG FSKEELTWLQ SLRGVPHVIQ TQLSPVLLYL
TDLDQFLHHW DVTEAVFHSL LVIPARSQNF DILQSAISKH LVGLTVIPDS TAGCVFGVIC
KLLDHTCVVS ETLLPFLASC CYSLLYFLLT IEKGEAEHLR KRDKLWGVCV SILALLPRVL
RLMLQSLRVN RVGPEELPVV GQLLRLLLQH APLRTHMLTN AILVQQIIKN ITTLKSGSVQ
EQWLTDLHYC FNVYITGHPQ GPSALATVY
