ID   TEX10_MOUSE             Reviewed;         928 AA.
AC   Q3URQ0;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Testis-expressed protein 10;
GN   Name=Tex10;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Lung, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [6]
RP   FUNCTION, IDENTIFICATION IN THE 5FMC COMPLEX, INTERACTION OF THE 5FMC
RP   COMPLEX WITH CHTOP AND ZNF148, AND SUBCELLULAR LOCATION.
RX   PubMed=22872859; DOI=10.1074/mcp.m112.017194;
RA   Fanis P., Gillemans N., Aghajanirefah A., Pourfarzad F., Demmers J.,
RA   Esteghamat F., Vadlamudi R.K., Grosveld F., Philipsen S., van Dijk T.B.;
RT   "Five friends of methylated chromatin target of protein-arginine-
RT   methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation
RT   to desumoylation.";
RL   Mol. Cell. Proteomics 11:1263-1273(2012).
CC   -!- FUNCTION: Functions as a component of the Five Friends of Methylated
CC       CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by
CC       methylated CHTOP, leading to desumoylation of ZNF148 and subsequent
CC       transactivation of ZNF148 target genes (PubMed:22872859). Component of
CC       the PELP1 complex involved in the nucleolar steps of 28S rRNA
CC       maturation and the subsequent nucleoplasmic transit of the pre-60S
CC       ribosomal subunit (By similarity). {ECO:0000250|UniProtKB:Q9NXF1,
CC       ECO:0000269|PubMed:22872859}.
CC   -!- SUBUNIT: Component of some MLL1/MLL complex, at least composed of the
CC       core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well
CC       as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1,
CC       LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2,
CC       RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and
CC       TEX10 (By similarity). Component of the 5FMC complex, at least composed
CC       of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with
CC       methylated CHTOP and ZNF148 (PubMed:22872859). Component of the PELP1
CC       complex, composed of at least PELP1, TEX10 and WDR18. The complex
CC       interacts with pre-60S ribosome particles (By similarity).
CC       {ECO:0000250|UniProtKB:Q9NXF1, ECO:0000269|PubMed:22872859}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9NXF1}. Nucleus, nucleoplasm
CC       {ECO:0000269|PubMed:22872859}. Cytoplasm {ECO:0000269|PubMed:22872859}.
CC       Note=Mainly found in the nucleoplasm, with low levels detected in the
CC       cytoplasmic and chromatin fractions. {ECO:0000269|PubMed:22872859}.
CC   -!- SIMILARITY: Belongs to the IPI1/TEX10 family. {ECO:0000305}.
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DR   EMBL; AK132870; BAE21398.1; -; mRNA.
DR   EMBL; AK141288; BAE24638.1; -; mRNA.
DR   EMBL; AL807247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466565; EDL02335.1; -; Genomic_DNA.
DR   EMBL; BC151176; AAI51177.1; -; mRNA.
DR   EMBL; BC151177; AAI51178.1; -; mRNA.
DR   CCDS; CCDS38760.1; -.
DR   RefSeq; NP_758508.2; NM_172304.3.
DR   RefSeq; XP_006538018.1; XM_006537955.3.
DR   RefSeq; XP_006538019.1; XM_006537956.2.
DR   AlphaFoldDB; Q3URQ0; -.
DR   BioGRID; 234665; 5.
DR   IntAct; Q3URQ0; 5.
DR   STRING; 10090.ENSMUSP00000132498; -.
DR   iPTMnet; Q3URQ0; -.
DR   PhosphoSitePlus; Q3URQ0; -.
DR   EPD; Q3URQ0; -.
DR   MaxQB; Q3URQ0; -.
DR   PaxDb; Q3URQ0; -.
DR   PeptideAtlas; Q3URQ0; -.
DR   PRIDE; Q3URQ0; -.
DR   ProteomicsDB; 263283; -.
DR   Antibodypedia; 43979; 30 antibodies from 13 providers.
DR   Ensembl; ENSMUST00000030030; ENSMUSP00000030030; ENSMUSG00000028345.
DR   Ensembl; ENSMUST00000164866; ENSMUSP00000132498; ENSMUSG00000028345.
DR   GeneID; 269536; -.
DR   KEGG; mmu:269536; -.
DR   UCSC; uc008svd.1; mouse.
DR   CTD; 54881; -.
DR   MGI; MGI:1344413; Tex10.
DR   VEuPathDB; HostDB:ENSMUSG00000028345; -.
DR   eggNOG; KOG2149; Eukaryota.
DR   GeneTree; ENSGT00950000182992; -.
DR   HOGENOM; CLU_014208_0_0_1; -.
DR   InParanoid; Q3URQ0; -.
DR   OMA; THHWDIV; -.
DR   OrthoDB; 1285836at2759; -.
DR   PhylomeDB; Q3URQ0; -.
DR   TreeFam; TF318197; -.
DR   Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   BioGRID-ORCS; 269536; 24 hits in 72 CRISPR screens.
DR   ChiTaRS; Tex10; mouse.
DR   PRO; PR:Q3URQ0; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; Q3URQ0; protein.
DR   Bgee; ENSMUSG00000028345; Expressed in primitive streak and 245 other tissues.
DR   ExpressionAtlas; Q3URQ0; baseline and differential.
DR   Genevisible; Q3URQ0; MM.
DR   GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR   GO; GO:0071339; C:MLL1 complex; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR024679; Ipi1_N.
DR   InterPro; IPR037947; TEX10/Ipi1.
DR   PANTHER; PTHR16056:SF2; PTHR16056:SF2; 1.
DR   Pfam; PF12333; Ipi1_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..928
FT                   /note="Testis-expressed protein 10"
FT                   /id="PRO_0000391000"
FT   REPEAT          99..137
FT                   /note="HEAT"
FT   MOD_RES         29
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NXF1"
SQ   SEQUENCE   928 AA;  105209 MW;  05D38CBE5B3E8C2E CRC64;
     MTKKRKRQDD FQKVKLKVGK KKPKLENATA TNFKTKAIHL PEQLKEDRTL PTNNRKLNIK
     DLLSQMHHYS GGVKQSALLG LKDLLSQYPF IIDAHLSNIL SEVTAVFTDR DANVRLAAVQ
     LLQFLAPKIR TEHISPFFPL VSAHLSSAMT HITEGIQEDS LKVLDILLEH YPALITGRSS
     ILLKNFVELI SHQQLSKGLV NRDRSQSWIL SVNPNRRVTS QQWRLKVLAR LSKFLQALAD
     GSSRLRESEG LQEQKETPHA TSNSIFINWK DHANDQQQIQ VYENGGSQPN VSSQFRLRCL
     GTLGTVDEDL SSPENLKGFI EIIIPLLIEC WIEALPPQLA ASVGSGVERE PLQVMQQVLN
     VISLLWKLSK QQDETHTLES WLRKNYLTDF KHHFMSHFPY ALKEITKQRK KDTNKSIKHC
     TVLSNNVDHL LLNLTLSDIM VSLANASTLQ NDSSWIETIR KFVTETLKGG TRLNSKQLNR
     LLGVSWRLIQ MQPNRDATEN LIKAVYTLYQ QRGLLLPVRT LLIKFFSKIY QKEELRSYRL
     RYRSKVLSRW LAGLPLQLSY LGSRNPELST QLIDIIHTAA SQANKDLLKN LQAAALRIYD
     PQEGAVVVLP AESQQRLVQL LYFLPTLPAD LLSQLSRCCI MGRLGSSLAV TLIGILYMRS
     SFSGWSHSVN DCLMTDVDYL SFLFSTLTGF SKEELTWLQN LRGVPHVVQT SLSPVLLYLT
     DLDQFLHHWD ITEAVCHSLL VIPARSQSFD IMQSAISKHL VGLTVIPDST AGCIFGVMCK
     LLDHTCVVNE ALLPFLASCC YSLLYFLLTL EKGDAEHLKK RDKLWEVCVS ILALLPRVLR
     LMLQSLRVNR ASPEELPVVG QLLRLLLQHV PLRSHMLTNA ILVQQIIKNI TTLKSGSVQE
     QWLTDLHYCF SVYISGHPQG PSILNALY