ID   TEX10_PONAB             Reviewed;         929 AA.
AC   Q5RDK1;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Testis-expressed protein 10;
GN   Name=TEX10;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a component of the Five Friends of Methylated
CC       CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by
CC       methylated CHTOP, leading to desumoylation of ZNF148 and subsequent
CC       transactivation of ZNF148 target genes. Component of the PELP1 complex
CC       involved in the nucleolar steps of 28S rRNA maturation and the
CC       subsequent nucleoplasmic transit of the pre-60S ribosomal subunit.
CC       {ECO:0000250|UniProtKB:Q9NXF1}.
CC   -!- SUBUNIT: Component of some MLL1/MLL complex, at least composed of the
CC       core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well
CC       as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1,
CC       LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2,
CC       RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and
CC       TEX10. Component of the 5FMC complex, at least composed of PELP1,
CC       LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated
CC       CHTOP and ZNF148. Component of the PELP1 complex, composed of at least
CC       PELP1, TEX10 and WDR18. The complex interacts with pre-60S ribosome
CC       particles. {ECO:0000250|UniProtKB:Q9NXF1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9NXF1}. Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:Q3URQ0}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q3URQ0}. Note=Mainly found in the nucleoplasm,
CC       with low levels detected in the cytoplasmic and chromatin fractions.
CC       {ECO:0000250|UniProtKB:Q3URQ0}.
CC   -!- SIMILARITY: Belongs to the IPI1/TEX10 family. {ECO:0000305}.
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DR   EMBL; CR857906; CAH90156.1; -; mRNA.
DR   RefSeq; NP_001125045.1; NM_001131573.1.
DR   AlphaFoldDB; Q5RDK1; -.
DR   STRING; 9601.ENSPPYP00000021790; -.
DR   PRIDE; Q5RDK1; -.
DR   GeneID; 100171926; -.
DR   KEGG; pon:100171926; -.
DR   CTD; 54881; -.
DR   eggNOG; KOG2149; Eukaryota.
DR   InParanoid; Q5RDK1; -.
DR   OrthoDB; 1285836at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0071339; C:MLL1 complex; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR024679; Ipi1_N.
DR   InterPro; IPR037947; TEX10/Ipi1.
DR   PANTHER; PTHR16056:SF2; PTHR16056:SF2; 1.
DR   Pfam; PF12333; Ipi1_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..929
FT                   /note="Testis-expressed protein 10"
FT                   /id="PRO_0000072492"
FT   REPEAT          99..137
FT                   /note="HEAT"
FT   MOD_RES         29
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NXF1"
SQ   SEQUENCE   929 AA;  105689 MW;  08011E7C2D92A8A3 CRC64;
     MTKKRKRQDD FQKVKLKVGK KKPKLQNATP TNFKTKTIHL PEQLKEDGTL PTNNRKLNIE
     DLLSQMHHYN AGVKQSALLG LKDLLSQYPF IIDAHLSNIL SEVTAVFTDK DANVRLAAVQ
     LLQFLAPKIR AEQMSPFFPL VSAHLSSAMT HITEGIQEDS LKVLDILLEQ YPALITGRSS
     ILLKNFVELI SHQQLSKGLI NRDRSQSWIL SVNPNRRLTS QQWRLKVLVR LSKFLQALAD
     GSSRLRESEG LQEQKENPHA TSNSIFINWK EHANDQQHIQ VYENGGSQPN VSSQFRLRYL
     VGGLSGVDEG LSSTENLKGF IEIIIPLLIE CWVEAVPPQL ATPVGNGIER EPLQVMQQVL
     NIISLLWKLS KQQDETHKLE SWLRKNYLID FKHHFMSRFP YALKEITKHK RKEPNKSIKH
     CTVFSNNIDH LLLNLTLSDI MVSLANASTL QKDCSWIEMI RKFVTETLED GSRLNSKQLN
     RLLGVSWRLM QIQPNREDTE TLIKAVYTLY QQRGLILPVR TLLLKFFSKI YQTEELRSCR
     FRYRSKVLSR WLAGLPLQLA HLGSRNPELS TQLIDMIHTA AARANKELLK SLQATALRIY
     DPQEGAVVVL PADPQQRLVQ LVYFLPSLPA DLLSRLSRCC IMGRLSSSLA AMLIGILHMR
     SSFSGWKYSA KDWLMSDVDY FSFLFSTLTG FSKEELTRLQ SLRGVPHVIQ TQLSPVLLYL
     TDLDQFLHHW DVTEAVFHSL LVIPARSQNF DILQSAISKH LVGLTVIPDS TAGCVFGVIC
     KLLDHTCIVS ETLLPFLASC CYSLLYFLLT IEKGEAEHLR KRDKLWGVCV SILALLPRVL
     RLMLQSLRVN RVGPEELPVV GQLLRLLLQH APLRTHMLTN AILVQQIIKN ITTLKSGSVQ
     EQWLTDLHYC FNVYITGHPQ GPSALATVY