TEX11_HUMAN
ID TEX11_HUMAN Reviewed; 940 AA.
AC Q8IYF3; A8K8V6; Q5JQQ8; Q96LZ4; Q96M47; Q9BXU6;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 3.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Testis-expressed protein 11;
DE AltName: Full=Protein ZIP4 homolog {ECO:0000250|UniProtKB:Q14AT2};
DE Short=ZIP4H;
GN Name=TEX11; Synonyms=ZIP4 {ECO:0000250|UniProtKB:Q14AT2};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT LYS-451.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 20-940 (ISOFORM 3).
RC TISSUE=Testis;
RX PubMed=11279525; DOI=10.1038/86927;
RA Wang P.J., McCarrey J.R., Yang F., Page D.C.;
RT "An abundance of X-linked genes expressed in spermatogonia.";
RL Nat. Genet. 27:422-426(2001).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=18369460; DOI=10.1371/journal.pgen.1000042;
RA Adelman C.A., Petrini J.H.;
RT "ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break
RT repair and the regulation of crossing over.";
RL PLoS Genet. 4:E1000042-E1000042(2008).
RN [7]
RP INVOLVEMENT IN SPGFX2, AND VARIANTS SPGFX2 VAL-171 AND THR-698.
RX PubMed=25970010; DOI=10.1056/nejmoa1406192;
RA Yatsenko A.N., Georgiadis A.P., Roepke A., Berman A.J., Jaffe T.,
RA Olszewska M., Westernstroeer B., Sanfilippo J., Kurpisz M., Rajkovic A.,
RA Yatsenko S.A., Kliesch S., Schlatt S., Tuettelmann F.;
RT "X-linked TEX11 mutations, meiotic arrest, and azoospermia in infertile
RT men.";
RL N. Engl. J. Med. 372:2097-2107(2015).
RN [8]
RP INTERACTION WITH SHOC1.
RX PubMed=29742103; DOI=10.1371/journal.pgen.1007381;
RA Guiraldelli M.F., Felberg A., Almeida L.P., Parikh A., de Castro R.O.,
RA Pezza R.J.;
RT "SHOC1 is a ERCC4-(HhH)2-like protein, integral to the formation of
RT crossover recombination intermediates during mammalian meiosis.";
RL PLoS Genet. 14:E1007381-E1007381(2018).
RN [9]
RP VARIANT SPGFX2 VAL-171.
RX PubMed=28718531; DOI=10.1111/andr.12378;
RA Nakamura S., Miyado M., Saito K., Katsumi M., Nakamura A., Kobori Y.,
RA Tanaka Y., Ishikawa H., Yoshida A., Okada H., Hata K., Nakabayashi K.,
RA Okamura K., Ogata H., Matsubara Y., Ogata T., Nakai H., Fukami M.;
RT "Next-generation sequencing for patients with non-obstructive azoospermia:
RT implications for significant roles of monogenic/oligogenic mutations.";
RL Andrology 5:824-831(2017).
CC -!- FUNCTION: Regulator of crossing-over during meiosis. Involved in
CC initiation and/or maintenance of chromosome synapsis and formation of
CC crossovers. {ECO:0000250|UniProtKB:Q14AT2}.
CC -!- SUBUNIT: Interacts with SYCP2. Interacts with PBXIP1; may prevent
CC interaction between PBXIP1 and ESR2 (By similarity). Interacts with
CC SHOC1 (PubMed:29742103). {ECO:0000250|UniProtKB:Q14AT2,
CC ECO:0000269|PubMed:29742103}.
CC -!- INTERACTION:
CC Q8IYF3; Q9HBH7: BEX1; NbExp=3; IntAct=EBI-742397, EBI-7162175;
CC Q8IYF3; Q96FH0: BORCS8; NbExp=5; IntAct=EBI-742397, EBI-744076;
CC Q8IYF3; Q5I0X4: C6orf226; NbExp=3; IntAct=EBI-742397, EBI-10244057;
CC Q8IYF3; Q8NA61: CBY2; NbExp=3; IntAct=EBI-742397, EBI-741724;
CC Q8IYF3; Q9NVL8: CCDC198; NbExp=3; IntAct=EBI-742397, EBI-10238351;
CC Q8IYF3; P38936: CDKN1A; NbExp=4; IntAct=EBI-742397, EBI-375077;
CC Q8IYF3; Q6IPU0: CENPP; NbExp=3; IntAct=EBI-742397, EBI-10250303;
CC Q8IYF3; Q9P218-2: COL20A1; NbExp=3; IntAct=EBI-742397, EBI-10318410;
CC Q8IYF3; O95715: CXCL14; NbExp=3; IntAct=EBI-742397, EBI-2798068;
CC Q8IYF3; Q9H596: DUSP21; NbExp=3; IntAct=EBI-742397, EBI-7357329;
CC Q8IYF3; Q8NDB6: FAM156A; NbExp=3; IntAct=EBI-742397, EBI-749727;
CC Q8IYF3; Q8TES7-6: FBF1; NbExp=3; IntAct=EBI-742397, EBI-10244131;
CC Q8IYF3; Q8WXI9: GATAD2B; NbExp=3; IntAct=EBI-742397, EBI-923440;
CC Q8IYF3; Q5T013: HYI; NbExp=4; IntAct=EBI-742397, EBI-749235;
CC Q8IYF3; A0A0C4DG38: ING3; NbExp=3; IntAct=EBI-742397, EBI-10263367;
CC Q8IYF3; Q96GY3: LIN37; NbExp=2; IntAct=EBI-742397, EBI-748884;
CC Q8IYF3; P45984: MAPK9; NbExp=3; IntAct=EBI-742397, EBI-713568;
CC Q8IYF3; O60336: MAPKBP1; NbExp=3; IntAct=EBI-742397, EBI-947402;
CC Q8IYF3; Q9P2K5-2: MYEF2; NbExp=3; IntAct=EBI-742397, EBI-10318831;
CC Q8IYF3; I6L9F6: NEFL; NbExp=4; IntAct=EBI-742397, EBI-10178578;
CC Q8IYF3; Q96HA1: POM121; NbExp=4; IntAct=EBI-742397, EBI-739990;
CC Q8IYF3; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-742397, EBI-2557469;
CC Q8IYF3; Q8IX06: REXO1L1P; NbExp=3; IntAct=EBI-742397, EBI-10262361;
CC Q8IYF3; Q8N443: RIBC1; NbExp=3; IntAct=EBI-742397, EBI-10265323;
CC Q8IYF3; Q8WYJ6: SEPTIN1; NbExp=3; IntAct=EBI-742397, EBI-693002;
CC Q8IYF3; Q13573: SNW1; NbExp=3; IntAct=EBI-742397, EBI-632715;
CC Q8IYF3; Q9UNH6: SNX7; NbExp=4; IntAct=EBI-742397, EBI-751422;
CC Q8IYF3; Q93045: STMN2; NbExp=5; IntAct=EBI-742397, EBI-714194;
CC Q8IYF3; Q9NU19: TBC1D22B; NbExp=3; IntAct=EBI-742397, EBI-8787464;
CC Q8IYF3; Q9BVW5: TIPIN; NbExp=3; IntAct=EBI-742397, EBI-2515360;
CC Q8IYF3; Q8IV54: TSC22D4; NbExp=3; IntAct=EBI-742397, EBI-10261521;
CC Q8IYF3; Q08E77: UTP14C; NbExp=3; IntAct=EBI-742397, EBI-10225961;
CC Q8IYF3-3; P54252: ATXN3; NbExp=6; IntAct=EBI-11523345, EBI-946046;
CC Q8IYF3-3; Q92843: BCL2L2; NbExp=3; IntAct=EBI-11523345, EBI-707714;
CC Q8IYF3-3; Q96FH0: BORCS8; NbExp=5; IntAct=EBI-11523345, EBI-744076;
CC Q8IYF3-3; Q5PSV4: BRMS1L; NbExp=3; IntAct=EBI-11523345, EBI-5666615;
CC Q8IYF3-3; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-11523345, EBI-11524851;
CC Q8IYF3-3; E9PSE9: CCDC198; NbExp=4; IntAct=EBI-11523345, EBI-11748295;
CC Q8IYF3-3; P04233-2: CD74; NbExp=3; IntAct=EBI-11523345, EBI-12222807;
CC Q8IYF3-3; Q5SZL2-5: CEP85L; NbExp=3; IntAct=EBI-11523345, EBI-12344751;
CC Q8IYF3-3; Q08495: DMTN; NbExp=3; IntAct=EBI-11523345, EBI-715275;
CC Q8IYF3-3; Q9H596: DUSP21; NbExp=3; IntAct=EBI-11523345, EBI-7357329;
CC Q8IYF3-3; Q5JVL4: EFHC1; NbExp=6; IntAct=EBI-11523345, EBI-743105;
CC Q8IYF3-3; Q6NZ36-4: FAAP20; NbExp=3; IntAct=EBI-11523345, EBI-12013806;
CC Q8IYF3-3; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-11523345, EBI-7225287;
CC Q8IYF3-3; Q8IXS0: FAM217A; NbExp=3; IntAct=EBI-11523345, EBI-10694567;
CC Q8IYF3-3; Q9Y4H4: GPSM3; NbExp=3; IntAct=EBI-11523345, EBI-347538;
CC Q8IYF3-3; A8MXD5: GRXCR1; NbExp=3; IntAct=EBI-11523345, EBI-5235612;
CC Q8IYF3-3; P09067: HOXB5; NbExp=3; IntAct=EBI-11523345, EBI-3893317;
CC Q8IYF3-3; A0A0C4DG38: ING3; NbExp=3; IntAct=EBI-11523345, EBI-10263367;
CC Q8IYF3-3; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-11523345, EBI-2556193;
CC Q8IYF3-3; Q9H3F6: KCTD10; NbExp=3; IntAct=EBI-11523345, EBI-2505886;
CC Q8IYF3-3; P04259: KRT6B; NbExp=3; IntAct=EBI-11523345, EBI-740907;
CC Q8IYF3-3; Q5VUJ6-2: LRCH2; NbExp=3; IntAct=EBI-11523345, EBI-12287681;
CC Q8IYF3-3; Q1X8D7: LRRC36; NbExp=3; IntAct=EBI-11523345, EBI-12218159;
CC Q8IYF3-3; P45984: MAPK9; NbExp=3; IntAct=EBI-11523345, EBI-713568;
CC Q8IYF3-3; O60336: MAPKBP1; NbExp=3; IntAct=EBI-11523345, EBI-947402;
CC Q8IYF3-3; Q9Y605: MRFAP1; NbExp=3; IntAct=EBI-11523345, EBI-995714;
CC Q8IYF3-3; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-11523345, EBI-10172876;
CC Q8IYF3-3; I6L9F6: NEFL; NbExp=3; IntAct=EBI-11523345, EBI-10178578;
CC Q8IYF3-3; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-11523345, EBI-2557469;
CC Q8IYF3-3; O60256: PRPSAP2; NbExp=3; IntAct=EBI-11523345, EBI-724960;
CC Q8IYF3-3; A2A3K4: PTPDC1; NbExp=3; IntAct=EBI-11523345, EBI-11603375;
CC Q8IYF3-3; Q9UPN6: SCAF8; NbExp=3; IntAct=EBI-11523345, EBI-7954236;
CC Q8IYF3-3; Q9UNH7: SNX6; NbExp=3; IntAct=EBI-11523345, EBI-949294;
CC Q8IYF3-3; P35711-4: SOX5; NbExp=3; IntAct=EBI-11523345, EBI-11954419;
CC Q8IYF3-3; Q93045: STMN2; NbExp=3; IntAct=EBI-11523345, EBI-714194;
CC Q8IYF3-3; Q9Y4E8-2: USP15; NbExp=3; IntAct=EBI-11523345, EBI-12041225;
CC Q8IYF3-3; Q5TAP6: UTP14C; NbExp=3; IntAct=EBI-11523345, EBI-11737646;
CC Q8IYF3-3; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-11523345, EBI-744257;
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q14AT2}.
CC Note=Forms arrays of discrete foci along synaptonemal complexes in
CC spermatocytes and fetal oocytes. {ECO:0000250|UniProtKB:Q14AT2}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8IYF3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IYF3-2; Sequence=VSP_027260;
CC Name=3;
CC IsoId=Q8IYF3-3; Sequence=VSP_027261;
CC -!- TISSUE SPECIFICITY: Testis-specific. Not expressed in adult ovaries.
CC {ECO:0000269|PubMed:18369460}.
CC -!- DISEASE: Spermatogenic failure, X-linked, 2 (SPGFX2) [MIM:309120]: An
CC infertility disorder caused by spermatogenesis defects. It is
CC characterized by mixed testicular atrophy and azoospermia with meiotic
CC arrest. {ECO:0000269|PubMed:25970010, ECO:0000269|PubMed:28718531}.
CC Note=The disease is caused by variants affecting the gene represented
CC in this entry.
CC -!- SIMILARITY: Belongs to the SPO22 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK31973.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK057391; BAB71465.1; -; mRNA.
DR EMBL; AK057523; BAB71520.1; -; mRNA.
DR EMBL; AK292471; BAF85160.1; -; mRNA.
DR EMBL; AL139109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL627071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL627390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471132; EAX05331.1; -; Genomic_DNA.
DR EMBL; BC036016; AAH36016.2; -; mRNA.
DR EMBL; AF285594; AAK31973.1; ALT_INIT; mRNA.
DR CCDS; CCDS35323.1; -. [Q8IYF3-1]
DR CCDS; CCDS43968.1; -. [Q8IYF3-3]
DR RefSeq; NP_001003811.1; NM_001003811.1. [Q8IYF3-1]
DR RefSeq; NP_112566.2; NM_031276.2. [Q8IYF3-3]
DR RefSeq; XP_011529298.1; XM_011530996.1. [Q8IYF3-2]
DR AlphaFoldDB; Q8IYF3; -.
DR SMR; Q8IYF3; -.
DR BioGRID; 121093; 100.
DR IntAct; Q8IYF3; 75.
DR MINT; Q8IYF3; -.
DR STRING; 9606.ENSP00000379226; -.
DR iPTMnet; Q8IYF3; -.
DR PhosphoSitePlus; Q8IYF3; -.
DR BioMuta; TEX11; -.
DR DMDM; 156637425; -.
DR EPD; Q8IYF3; -.
DR MassIVE; Q8IYF3; -.
DR PaxDb; Q8IYF3; -.
DR PeptideAtlas; Q8IYF3; -.
DR PRIDE; Q8IYF3; -.
DR ProteomicsDB; 71166; -. [Q8IYF3-1]
DR ProteomicsDB; 71167; -. [Q8IYF3-2]
DR ProteomicsDB; 71168; -. [Q8IYF3-3]
DR Antibodypedia; 508; 82 antibodies from 26 providers.
DR DNASU; 56159; -.
DR Ensembl; ENST00000344304.3; ENSP00000340995.3; ENSG00000120498.14. [Q8IYF3-1]
DR Ensembl; ENST00000374320.6; ENSP00000363440.2; ENSG00000120498.14. [Q8IYF3-2]
DR Ensembl; ENST00000374333.7; ENSP00000363453.2; ENSG00000120498.14. [Q8IYF3-3]
DR Ensembl; ENST00000395889.6; ENSP00000379226.2; ENSG00000120498.14. [Q8IYF3-1]
DR GeneID; 56159; -.
DR KEGG; hsa:56159; -.
DR MANE-Select; ENST00000374333.7; ENSP00000363453.2; NM_031276.3; NP_112566.2. [Q8IYF3-3]
DR UCSC; uc004dyk.4; human. [Q8IYF3-1]
DR CTD; 56159; -.
DR DisGeNET; 56159; -.
DR GeneCards; TEX11; -.
DR HGNC; HGNC:11733; TEX11.
DR HPA; ENSG00000120498; Tissue enriched (pancreas).
DR MalaCards; TEX11; -.
DR MIM; 300311; gene.
DR MIM; 309120; phenotype.
DR neXtProt; NX_Q8IYF3; -.
DR OpenTargets; ENSG00000120498; -.
DR Orphanet; 399805; Male infertility with azoospermia or oligozoospermia due to single gene mutation.
DR PharmGKB; PA36450; -.
DR VEuPathDB; HostDB:ENSG00000120498; -.
DR eggNOG; KOG4814; Eukaryota.
DR GeneTree; ENSGT00390000006492; -.
DR HOGENOM; CLU_018086_0_0_1; -.
DR InParanoid; Q8IYF3; -.
DR OMA; SMDFKEV; -.
DR OrthoDB; 681770at2759; -.
DR PhylomeDB; Q8IYF3; -.
DR TreeFam; TF333356; -.
DR PathwayCommons; Q8IYF3; -.
DR SignaLink; Q8IYF3; -.
DR BioGRID-ORCS; 56159; 10 hits in 701 CRISPR screens.
DR ChiTaRS; TEX11; human.
DR GenomeRNAi; 56159; -.
DR Pharos; Q8IYF3; Tbio.
DR PRO; PR:Q8IYF3; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q8IYF3; protein.
DR Bgee; ENSG00000120498; Expressed in sperm and 59 other tissues.
DR Genevisible; Q8IYF3; HS.
DR GO; GO:0000801; C:central element; IBA:GO_Central.
DR GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:0051026; P:chiasma assembly; IEA:Ensembl.
DR GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
DR GO; GO:0009566; P:fertilization; IEA:Ensembl.
DR GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR GO; GO:0007060; P:male meiosis chromosome segregation; IBA:GO_Central.
DR GO; GO:0006311; P:meiotic gene conversion; ISS:UniProtKB.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0051093; P:negative regulation of developmental process; IEA:Ensembl.
DR GO; GO:2000242; P:negative regulation of reproductive process; IEA:Ensembl.
DR GO; GO:0007131; P:reciprocal meiotic recombination; ISS:UniProtKB.
DR GO; GO:0000712; P:resolution of meiotic recombination intermediates; IEA:Ensembl.
DR GO; GO:0007130; P:synaptonemal complex assembly; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR013940; Spo22/ZIP4/TEX11.
DR InterPro; IPR042861; TEX11.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR47083; PTHR47083; 1.
DR Pfam; PF08631; SPO22; 1.
DR SMART; SM00028; TPR; 2.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chromosome; Disease variant; Meiosis;
KW Reference proteome.
FT CHAIN 1..940
FT /note="Testis-expressed protein 11"
FT /id="PRO_0000296955"
FT VAR_SEQ 1..325
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027260"
FT VAR_SEQ 1..27
FT /note="MISAHCNLRLLCSSDSSASASQVAGTT -> MDNDDFFSMDFK (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:11279525,
FT ECO:0000303|PubMed:14702039, ECO:0000303|PubMed:15489334"
FT /id="VSP_027261"
FT VARIANT 130
FT /note="K -> R (in dbSNP:rs6525433)"
FT /id="VAR_034635"
FT VARIANT 171
FT /note="M -> V (in SPGFX2; dbSNP:rs143246552)"
FT /evidence="ECO:0000269|PubMed:25970010,
FT ECO:0000269|PubMed:28718531"
FT /id="VAR_073889"
FT VARIANT 451
FT /note="E -> K (in dbSNP:rs4844247)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_034636"
FT VARIANT 698
FT /note="A -> T (in SPGFX2; dbSNP:rs140984555)"
FT /evidence="ECO:0000269|PubMed:25970010"
FT /id="VAR_073890"
FT CONFLICT 65
FT /note="T -> A (in Ref. 1; BAB71520)"
FT /evidence="ECO:0000305"
FT CONFLICT 600
FT /note="K -> E (in Ref. 1; BAB71465)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 940 AA; 107889 MW; 20A3B0BF58B82EF9 CRC64;
MISAHCNLRL LCSSDSSASA SQVAGTTEVV ENLVTNDNSP NIPEAIDRLF SDIANINRES
MAEITDIQIE EMAVNLWNWA LTIGGGWLVN EEQKIRLHYV ACKLLSMCEA SFASEQSIQR
LIMMNMRIGK EWLDAGNFLI ADECFQAAVA SLEQLYVKLI QRSSPEADLT MEKITVESDH
FRVLSYQAES AVAQGDFQRA SMCVLQCKDM LMRLPQMTSS LHHLCYNFGV ETQKNNKYEE
SSFWLSQSYD IGKMDKKSTG PEMLAKVLRL LATNYLDWDD TKYYDKALNA VNLANKEHLS
SPGLFLKMKI LLKGETSNEE LLEAVMEILH LDMPLDFCLN IAKLLMDHER ESVGFHFLTI
IHERFKSSEN IGKVLILHTD MLLQRKEELL AKEKIEEIFL AHQTGRQLTA ESMNWLHNIL
WRQAASSFEV QNYTDALQWY YYSLRFYSTD EMDLDFTKLQ RNMACCYLNL QQLDKAKEAV
AEAERHDPRN VFTQFYIFKI AVIEGNSERA LQAIITLENI LTDEESEDND LVAERGSPTM
LLSLAAQFAL ENGQQIVAEK ALEYLAQHSE DQEQVLTAVK CLLRFLLPKI AEMPESEDKK
KEMDRLLTCL NRAFVKLSQP FGEEALSLES RANEAQWFRK TAWNLAVQCD KDPVMMREFF
ILSYKMSQFC PSDQVILIAR KTCLLMAVAV DLEQGRKAST AFEQTMFLSR ALEEIQTCND
IHNFLKQTGT FSNDSCEKLL LLYEFEVRAK LNDPLLESFL ESVWELPHLE TKTFETIAII
AMEKPAHYPL IALKALKKAL LLYKKEEPID ISQYSKCMHN LVNLSVPDGA SNVELCPLEE
VWGYFEDALS HISRTKDYPE MEILWLMVKS WNTGVLMFSR SKYASAEKWC GLALRFLNHL
TSFKESYETQ MNMLYSQLVE ALSNNKGPVF HEHGYWSKSD
