TEX11_MOUSE
ID TEX11_MOUSE Reviewed; 947 AA.
AC Q14AT2; Q8BUS0; Q99MW9;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Testis-expressed protein 11;
DE AltName: Full=Protein ZIP4 homolog {ECO:0000303|PubMed:30272023};
DE Short=ZIP4H;
GN Name=Tex11; Synonyms=Zip4 {ECO:0000303|PubMed:30272023};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=11279525; DOI=10.1038/86927;
RA Wang P.J., McCarrey J.R., Yang F., Page D.C.;
RT "An abundance of X-linked genes expressed in spermatogonia.";
RL Nat. Genet. 27:422-426(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP AND INTERACTION WITH SYCP2.
RX PubMed=18316482; DOI=10.1101/gad.1613608;
RA Yang F., Gell K., van der Heijden G.W., Eckardt S., Leu N.A., Page D.C.,
RA Benavente R., Her C., Hoog C., McLaughlin K.J., Wang P.J.;
RT "Meiotic failure in male mice lacking an X-linked factor.";
RL Genes Dev. 22:682-691(2008).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP AND DISRUPTION PHENOTYPE.
RX PubMed=18369460; DOI=10.1371/journal.pgen.1000042;
RA Adelman C.A., Petrini J.H.;
RT "ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break
RT repair and the regulation of crossing over.";
RL PLoS Genet. 4:E1000042-E1000042(2008).
RN [7]
RP INTERACTION WITH PBXIP1.
RX PubMed=22383461; DOI=10.1210/me.2011-1263;
RA Yu Y.H., Siao F.P., Hsu L.C., Yen P.H.;
RT "TEX11 modulates germ cell proliferation by competing with estrogen
RT receptor beta for the binding to HPIP.";
RL Mol. Endocrinol. 26:630-642(2012).
RN [8]
RP SUBCELLULAR LOCATION.
RX PubMed=30272023; DOI=10.1038/s42003-018-0154-z;
RA Zhang Q., Shao J., Fan H.Y., Yu C.;
RT "Evolutionarily-conserved MZIP2 is essential for crossover formation in
RT mammalian meiosis.";
RL Commun. Biol. 1:147-147(2018).
RN [9]
RP SUBCELLULAR LOCATION.
RX PubMed=30746471; DOI=10.1126/sciadv.aau9780;
RA Zhang Q., Ji S.Y., Busayavalasa K., Yu C.;
RT "SPO16 binds SHOC1 to promote homologous recombination and crossing-over in
RT meiotic prophase I.";
RL Sci. Adv. 5:eaau9780-eaau9780(2019).
CC -!- FUNCTION: Regulator of crossing-over during meiosis. Involved in
CC initiation and/or maintenance of chromosome synapsis and formation of
CC crossovers. {ECO:0000269|PubMed:18316482, ECO:0000269|PubMed:18369460}.
CC -!- SUBUNIT: Interacts with SYCP2 (PubMed:18316482). Interacts with PBXIP1;
CC may prevent interaction between PBXIP1 and ESR2 (PubMed:22383461).
CC Interacts with SHOC1 (By similarity). {ECO:0000250|UniProtKB:Q8IYF3,
CC ECO:0000269|PubMed:18316482, ECO:0000269|PubMed:22383461}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:18316482,
CC ECO:0000269|PubMed:18369460, ECO:0000269|PubMed:30272023,
CC ECO:0000269|PubMed:30746471}. Note=Forms arrays of discrete foci along
CC synaptonemal complexes in spermatocytes and fetal oocytes.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q14AT2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q14AT2-2; Sequence=VSP_027262, VSP_027263;
CC -!- TISSUE SPECIFICITY: Testis-specific. {ECO:0000269|PubMed:11279525,
CC ECO:0000269|PubMed:18316482, ECO:0000269|PubMed:18369460}.
CC -!- DEVELOPMENTAL STAGE: In spermatocytes, not observed on asynapsed
CC chromosomes in leptotene and appears on synapsed regions in zygotene
CC and on the fully synapsed chromosomes in early pachytene. Disappears in
CC late pachytene and is not observed in diplotene spermatocytes. A
CC similar localization is detected on female meiotic chromosomes (at
CC protein level). {ECO:0000269|PubMed:18316482,
CC ECO:0000269|PubMed:18369460}.
CC -!- DISRUPTION PHENOTYPE: Defects in meiotic double-strand breaks (DSBs)
CC repair and reduced crossover formation. However, discrepancies exist
CC between the different reports. According to a report, deletion induces
CC male sterility (PubMed:18316482). Females are fertile with reduced
CC litter. Adult mice show an arrest in male meiosis and aberrant
CC chromosome segregation in anaphase spermatocytes. Chromosomal asynapsis
CC and reduced crossover formation are observed, leading to elimination of
CC spermatocytes at the pachytene and anaphase I stages (PubMed:18316482).
CC According to another report, both male and female mice are fertile and
CC produce normal-sized litters with normal Mendelian ratios
CC (PubMed:18369460). {ECO:0000269|PubMed:18316482,
CC ECO:0000269|PubMed:18369460}.
CC -!- MISCELLANEOUS: Represent the only meiosis-specific factor encoded by
CC the chromosome X in mouse. {ECO:0000305|PubMed:18316482}.
CC -!- SIMILARITY: Belongs to the SPO22 family. {ECO:0000305}.
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DR EMBL; AF285572; AAK31951.1; -; mRNA.
DR EMBL; AK082794; BAC38624.1; -; mRNA.
DR EMBL; AL672308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX005480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX072567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC116709; AAI16710.1; -; mRNA.
DR CCDS; CCDS30308.1; -. [Q14AT2-1]
DR CCDS; CCDS53150.1; -. [Q14AT2-2]
DR RefSeq; NP_001161469.1; NM_001167997.1. [Q14AT2-2]
DR RefSeq; NP_113561.2; NM_031384.2. [Q14AT2-1]
DR AlphaFoldDB; Q14AT2; -.
DR BioGRID; 219944; 3.
DR STRING; 10090.ENSMUSP00000109345; -.
DR iPTMnet; Q14AT2; -.
DR PhosphoSitePlus; Q14AT2; -.
DR PaxDb; Q14AT2; -.
DR PRIDE; Q14AT2; -.
DR ProteomicsDB; 262760; -. [Q14AT2-1]
DR ProteomicsDB; 262761; -. [Q14AT2-2]
DR Antibodypedia; 508; 82 antibodies from 26 providers.
DR DNASU; 83558; -.
DR Ensembl; ENSMUST00000009814; ENSMUSP00000009814; ENSMUSG00000009670. [Q14AT2-1]
DR Ensembl; ENSMUST00000113716; ENSMUSP00000109345; ENSMUSG00000009670. [Q14AT2-2]
DR Ensembl; ENSMUST00000113718; ENSMUSP00000109347; ENSMUSG00000009670. [Q14AT2-1]
DR GeneID; 83558; -.
DR KEGG; mmu:83558; -.
DR UCSC; uc009tws.2; mouse. [Q14AT2-1]
DR UCSC; uc012hmv.1; mouse. [Q14AT2-2]
DR CTD; 56159; -.
DR MGI; MGI:1933237; Tex11.
DR VEuPathDB; HostDB:ENSMUSG00000009670; -.
DR eggNOG; KOG4814; Eukaryota.
DR GeneTree; ENSGT00390000006492; -.
DR HOGENOM; CLU_018086_0_0_1; -.
DR InParanoid; Q14AT2; -.
DR OMA; SMDFKEV; -.
DR OrthoDB; 681770at2759; -.
DR PhylomeDB; Q14AT2; -.
DR TreeFam; TF333356; -.
DR BioGRID-ORCS; 83558; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Tex11; mouse.
DR PRO; PR:Q14AT2; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q14AT2; protein.
DR Bgee; ENSMUSG00000009670; Expressed in spermatid and 18 other tissues.
DR Genevisible; Q14AT2; MM.
DR GO; GO:0000801; C:central element; IDA:MGI.
DR GO; GO:0005694; C:chromosome; IDA:UniProtKB.
DR GO; GO:0000794; C:condensed nuclear chromosome; IDA:MGI.
DR GO; GO:0006915; P:apoptotic process; IMP:MGI.
DR GO; GO:0051026; P:chiasma assembly; IMP:MGI.
DR GO; GO:0035234; P:ectopic germ cell programmed cell death; IMP:MGI.
DR GO; GO:0009566; P:fertilization; IMP:MGI.
DR GO; GO:0008584; P:male gonad development; IMP:MGI.
DR GO; GO:0007060; P:male meiosis chromosome segregation; IMP:MGI.
DR GO; GO:0007140; P:male meiotic nuclear division; IMP:MGI.
DR GO; GO:0006311; P:meiotic gene conversion; IMP:UniProtKB.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
DR GO; GO:0051093; P:negative regulation of developmental process; IMP:MGI.
DR GO; GO:2000242; P:negative regulation of reproductive process; IMP:MGI.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IMP:UniProtKB.
DR GO; GO:0000712; P:resolution of meiotic recombination intermediates; IMP:MGI.
DR GO; GO:0007130; P:synaptonemal complex assembly; IMP:MGI.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR013940; Spo22/ZIP4/TEX11.
DR InterPro; IPR042861; TEX11.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR47083; PTHR47083; 1.
DR Pfam; PF08631; SPO22; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chromosome; Meiosis; Reference proteome.
FT CHAIN 1..947
FT /note="Testis-expressed protein 11"
FT /id="PRO_0000296956"
FT VAR_SEQ 691..707
FT /note="NMLLRTALEQIKKCKKV -> VSTKCKRGHQTFWNYRW (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027262"
FT VAR_SEQ 708..947
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027263"
FT CONFLICT 188
FT /note="M -> L (in Ref. 1; AAK31951)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 947 AA; 109624 MW; 3495B69473EB2797 CRC64;
MDRITDFYFL DFRESVKTLI ITGNSWRLQE MIDRFFTNIS NFNRESLTEI QNIQIEEIAV
NLWNWAVTKR VELSVRKNQA AKLCYIACKL VYMHGISVSS EEAIQRQILM NIKTGKEWLY
TGNAQIADEF FQAAMTDLER LYVRLMQSCY TEANVCVYKM IVEKGIFHVL SYQAESAVAQ
GDFKKASMCV LRCKDMLMRL PNMTKYLHVL CYNLGIEASK RNKYKESSFW LGQSYEIGKM
DRRSVEPQML AKTLRLLATI YLNCGGEAYY TKAFIAILIA NKEHLHPAGL FLKMRILMKG
NSCNEELLEA AKEILYLAMP LEFYLSIIQF LIDNKRESVG FRFLRIISDN FKSPEDRKRI
LLFYIDTLLQ KDQDMIAEEK IKDVLKGYQT RSRLSRDLVN WLHNILWGKA SRSVKVQKYA
DALHWYSYSL KLYEYDKADL DLIKLKRNMV SCYLSLKQLD KAKEAIAEVE QKDPTHVFTR
YYIFKIAIME GDAFRALQVV SALKKSLMDG ESEDRGLIEA GVSTLTILSL SIDFALENGQ
QFVAERALEY LCQLSKDPKE VLGGLKCLMR IILPQAFHMP ESEYKKKEMG RLWNYLNTAL
LKFSEYFNEA PSTLDYMVND ANWFRKIAWN LAVQSEKDLE AMKNFFMVSY KLSLFCPLDQ
GLLIAQKTCL LVAAAVDLDR GRKAPTICEQ NMLLRTALEQ IKKCKKVWNL LKKTGDFSGD
DCGVLLLLYE FEVKTKTNDP SLSRFVDSVW KMPDLECRTL ETMALLAMDK PAYYPTIAHK
AMKKLLLMYR KQEPVDVLKY SVCMHNLIKL LVADEVWNIS LYPLKEVQSH FKNTLSIIRQ
NEGYPEEEIV WLMIKSWNIG ILMSSKNKYI SAERWAAMAL DFLGHLSTLK TSYEAKVNLL
YANLMEILDK KTDLRSTEMT EQLRALIVPP EDQGSVSSTN VAAQNHL
