TEX12_HUMAN
ID TEX12_HUMAN Reviewed; 123 AA.
AC Q9BXU0; A6NDL9; B0YIX3;
DT 24-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Testis-expressed protein 12;
GN Name=TEX12;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=11279525; DOI=10.1038/86927;
RA Wang P.J., McCarrey J.R., Yang F., Page D.C.;
RT "An abundance of X-linked genes expressed in spermatogonia.";
RL Nat. Genet. 27:422-426(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG NHLBI resequencing and genotyping service (RS&G);
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the transverse central element of synaptonemal
CC complexes (SCS), formed between homologous chromosomes during meiotic
CC prophase (By similarity). Requires SYCP1 in order to be incorporated
CC into the central element (By similarity).
CC {ECO:0000250|UniProtKB:Q9CR81}.
CC -!- SUBUNIT: Interacts with SYCE2. {ECO:0000250|UniProtKB:Q9CR81}.
CC -!- INTERACTION:
CC Q9BXU0; Q13155: AIMP2; NbExp=3; IntAct=EBI-12090309, EBI-745226;
CC Q9BXU0; P63010-2: AP2B1; NbExp=3; IntAct=EBI-12090309, EBI-11529439;
CC Q9BXU0; Q9Y5Z0: BACE2; NbExp=3; IntAct=EBI-12090309, EBI-11282723;
CC Q9BXU0; P24863: CCNC; NbExp=3; IntAct=EBI-12090309, EBI-395261;
CC Q9BXU0; Q86XR8-3: CEP57; NbExp=3; IntAct=EBI-12090309, EBI-11752486;
CC Q9BXU0; P10606: COX5B; NbExp=3; IntAct=EBI-12090309, EBI-1053725;
CC Q9BXU0; P02489: CRYAA; NbExp=3; IntAct=EBI-12090309, EBI-6875961;
CC Q9BXU0; Q14204: DYNC1H1; NbExp=3; IntAct=EBI-12090309, EBI-356015;
CC Q9BXU0; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-12090309, EBI-7225287;
CC Q9BXU0; Q8IZT9: FAM9C; NbExp=3; IntAct=EBI-12090309, EBI-2870039;
CC Q9BXU0; P22607: FGFR3; NbExp=3; IntAct=EBI-12090309, EBI-348399;
CC Q9BXU0; Q14957: GRIN2C; NbExp=3; IntAct=EBI-12090309, EBI-8285963;
CC Q9BXU0; P01112: HRAS; NbExp=3; IntAct=EBI-12090309, EBI-350145;
CC Q9BXU0; Q0VD86: INCA1; NbExp=3; IntAct=EBI-12090309, EBI-6509505;
CC Q9BXU0; Q9Y2W7: KCNIP3; NbExp=3; IntAct=EBI-12090309, EBI-751501;
CC Q9BXU0; O14901: KLF11; NbExp=3; IntAct=EBI-12090309, EBI-948266;
CC Q9BXU0; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-12090309, EBI-726510;
CC Q9BXU0; Q14696: MESD; NbExp=3; IntAct=EBI-12090309, EBI-6165891;
CC Q9BXU0; A6NI15: MSGN1; NbExp=3; IntAct=EBI-12090309, EBI-11991020;
CC Q9BXU0; Q7Z3B4: NUP54; NbExp=3; IntAct=EBI-12090309, EBI-741048;
CC Q9BXU0; Q9BVL2: NUP58; NbExp=3; IntAct=EBI-12090309, EBI-2811583;
CC Q9BXU0; O43482: OIP5; NbExp=3; IntAct=EBI-12090309, EBI-536879;
CC Q9BXU0; Q13153: PAK1; NbExp=3; IntAct=EBI-12090309, EBI-1307;
CC Q9BXU0; Q96KQ4: PPP1R13B; NbExp=3; IntAct=EBI-12090309, EBI-1105153;
CC Q9BXU0; Q96ES7: SGF29; NbExp=3; IntAct=EBI-12090309, EBI-743117;
CC Q9BXU0; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-12090309, EBI-455078;
CC Q9BXU0; P51687: SUOX; NbExp=3; IntAct=EBI-12090309, EBI-3921347;
CC Q9BXU0; Q6PIF2: SYCE2; NbExp=5; IntAct=EBI-12090309, EBI-11958386;
CC Q9BXU0; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-12090309, EBI-741480;
CC Q9BXU0; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-12090309, EBI-5667516;
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q9CR81}.
CC Note=In prophase I stage of meiosis, localizes in the transverse
CC central elements of the central region between lateral elements of the
CC synaptonemal complexes. Found only where the chromosome cores are
CC synapsed. {ECO:0000250|UniProtKB:Q9CR81}.
CC -!- TISSUE SPECIFICITY: Testis specific.
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DR EMBL; AF285600; AAK31979.1; -; mRNA.
DR EMBL; AP002884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471065; EAW67187.1; -; Genomic_DNA.
DR EMBL; EF444956; ACA05953.1; -; Genomic_DNA.
DR EMBL; EF444956; ACA05955.1; -; Genomic_DNA.
DR EMBL; BC029506; AAH29506.1; -; mRNA.
DR CCDS; CCDS31679.1; -.
DR RefSeq; NP_112565.1; NM_031275.4.
DR PDB; 6HK8; X-ray; 2.11 A; A/B=49-113.
DR PDB; 6HK9; X-ray; 1.45 A; A/B=49-123.
DR PDB; 6R17; X-ray; 2.42 A; C/D=49-113.
DR PDB; 6R2F; X-ray; 2.29 A; A/B/C/D=49-123.
DR PDB; 6YQF; X-ray; 3.33 A; C/D=49-113.
DR PDBsum; 6HK8; -.
DR PDBsum; 6HK9; -.
DR PDBsum; 6R17; -.
DR PDBsum; 6R2F; -.
DR PDBsum; 6YQF; -.
DR AlphaFoldDB; Q9BXU0; -.
DR SMR; Q9BXU0; -.
DR BioGRID; 121092; 19.
DR IntAct; Q9BXU0; 30.
DR STRING; 9606.ENSP00000280358; -.
DR iPTMnet; Q9BXU0; -.
DR PhosphoSitePlus; Q9BXU0; -.
DR BioMuta; TEX12; -.
DR DMDM; 17368695; -.
DR MassIVE; Q9BXU0; -.
DR PaxDb; Q9BXU0; -.
DR PeptideAtlas; Q9BXU0; -.
DR PRIDE; Q9BXU0; -.
DR ProteomicsDB; 79516; -.
DR Antibodypedia; 45625; 120 antibodies from 18 providers.
DR DNASU; 56158; -.
DR Ensembl; ENST00000280358.5; ENSP00000280358.4; ENSG00000150783.10.
DR Ensembl; ENST00000530752.5; ENSP00000436893.1; ENSG00000150783.10.
DR GeneID; 56158; -.
DR KEGG; hsa:56158; -.
DR MANE-Select; ENST00000280358.5; ENSP00000280358.4; NM_031275.4; NP_112565.1.
DR UCSC; uc001pnc.4; human.
DR CTD; 56158; -.
DR DisGeNET; 56158; -.
DR GeneCards; TEX12; -.
DR HGNC; HGNC:11734; TEX12.
DR HPA; ENSG00000150783; Group enriched (retina, testis).
DR MIM; 605791; gene.
DR neXtProt; NX_Q9BXU0; -.
DR OpenTargets; ENSG00000150783; -.
DR PharmGKB; PA36451; -.
DR VEuPathDB; HostDB:ENSG00000150783; -.
DR eggNOG; ENOG502S8K9; Eukaryota.
DR GeneTree; ENSGT00390000006602; -.
DR HOGENOM; CLU_163464_0_0_1; -.
DR InParanoid; Q9BXU0; -.
DR OMA; RFTMIAN; -.
DR OrthoDB; 1488777at2759; -.
DR PhylomeDB; Q9BXU0; -.
DR TreeFam; TF330925; -.
DR PathwayCommons; Q9BXU0; -.
DR Reactome; R-HSA-1221632; Meiotic synapsis.
DR SignaLink; Q9BXU0; -.
DR SIGNOR; Q9BXU0; -.
DR BioGRID-ORCS; 56158; 5 hits in 1067 CRISPR screens.
DR GenomeRNAi; 56158; -.
DR Pharos; Q9BXU0; Tbio.
DR PRO; PR:Q9BXU0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9BXU0; protein.
DR Bgee; ENSG00000150783; Expressed in right testis and 95 other tissues.
DR ExpressionAtlas; Q9BXU0; baseline and differential.
DR Genevisible; Q9BXU0; HS.
DR GO; GO:0000801; C:central element; ISS:UniProtKB.
DR GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR GO; GO:0000711; P:meiotic DNA repair synthesis; IEA:Ensembl.
DR GO; GO:0007130; P:synaptonemal complex assembly; IBA:GO_Central.
DR InterPro; IPR029193; TEX12.
DR PANTHER; PTHR37349; PTHR37349; 1.
DR Pfam; PF15219; TEX12; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Chromosome; Meiosis; Reference proteome.
FT CHAIN 1..123
FT /note="Testis-expressed protein 12"
FT /id="PRO_0000072493"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 53..122
FT /evidence="ECO:0007829|PDB:6HK9"
SQ SEQUENCE 123 AA; 14107 MW; 47C45EA0BB722E09 CRC64;
MMANHLVKPD NRNCKRPREL ESPVPDSPQL SSLGKSDSSF SEISGLFYKD EALEKDLNDV
SKEINLMLST YAKLLSERAA VDASYIDEID ELFKEANAIE NFLIQKREFL RQRFTVIANT
LHR
