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TEX12_MOUSE
ID   TEX12_MOUSE             Reviewed;         123 AA.
AC   Q9CR81;
DT   24-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Testis-expressed protein 12;
GN   Name=Tex12;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Testis;
RX   PubMed=11279525; DOI=10.1038/86927;
RA   Wang P.J., McCarrey J.R., Yang F., Page D.C.;
RT   "An abundance of X-linked genes expressed in spermatogonia.";
RL   Nat. Genet. 27:422-426(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo, and Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INTERACTION WITH
RP   SYCE2.
RX   PubMed=16968740; DOI=10.1242/jcs.03182;
RA   Hamer G., Gell K., Kouznetsova A., Novak I., Benavente R., Hoeoeg C.;
RT   "Characterization of a novel meiosis-specific protein within the central
RT   element of the synaptonemal complex.";
RL   J. Cell Sci. 119:4025-4032(2006).
RN   [6]
RP   SUBCELLULAR LOCATION.
RX   PubMed=30949703; DOI=10.1093/nar/gkz226;
RA   Liu H., Huang T., Li M., Li M., Zhang C., Jiang J., Yu X., Yin Y.,
RA   Zhang F., Lu G., Luo M.C., Zhang L.R., Li J., Liu K., Chen Z.J.;
RT   "SCRE serves as a unique synaptonemal complex fastener and is essential for
RT   progression of meiosis prophase I in mice.";
RL   Nucleic Acids Res. 47:5670-5683(2019).
CC   -!- FUNCTION: Component of the transverse central element of synaptonemal
CC       complexes (SCS), formed between homologous chromosomes during meiotic
CC       prophase (PubMed:16968740). Requires SYCP1 in order to be incorporated
CC       into the central element (PubMed:16968740).
CC       {ECO:0000269|PubMed:16968740}.
CC   -!- SUBUNIT: Interacts with SYCE2. {ECO:0000269|PubMed:16968740}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:16968740,
CC       ECO:0000269|PubMed:30949703}. Note=In prophase I stage of meiosis,
CC       localizes in the transverse central elements of the central region
CC       between lateral elements of the synaptonemal complexes. Found only
CC       where the chromosome cores are synapsed. {ECO:0000269|PubMed:16968740}.
CC   -!- TISSUE SPECIFICITY: Testis (at protein level) (PubMed:11279525,
CC       PubMed:16968740). Detected in ovary (PubMed:16968740). Expressed in
CC       both male and female germ cells (PubMed:16968740).
CC       {ECO:0000269|PubMed:11279525, ECO:0000269|PubMed:16968740}.
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DR   EMBL; AF285582; AAK31961.1; -; mRNA.
DR   EMBL; AK017776; BAB30924.1; -; mRNA.
DR   EMBL; AK006285; BAB24504.1; -; mRNA.
DR   EMBL; AK014896; BAB29611.1; -; mRNA.
DR   EMBL; BC048458; AAH48458.1; -; mRNA.
DR   EMBL; BC061081; AAH61081.1; -; mRNA.
DR   CCDS; CCDS40621.1; -.
DR   RefSeq; NP_079963.1; NM_025687.3.
DR   AlphaFoldDB; Q9CR81; -.
DR   SMR; Q9CR81; -.
DR   BioGRID; 211624; 1.
DR   STRING; 10090.ENSMUSP00000034568; -.
DR   PhosphoSitePlus; Q9CR81; -.
DR   PaxDb; Q9CR81; -.
DR   PRIDE; Q9CR81; -.
DR   ProteomicsDB; 262875; -.
DR   Antibodypedia; 45625; 120 antibodies from 18 providers.
DR   DNASU; 66654; -.
DR   Ensembl; ENSMUST00000034568; ENSMUSP00000034568; ENSMUSG00000032065.
DR   Ensembl; ENSMUST00000217236; ENSMUSP00000149921; ENSMUSG00000032065.
DR   GeneID; 66654; -.
DR   KEGG; mmu:66654; -.
DR   UCSC; uc009pjs.1; mouse.
DR   CTD; 56158; -.
DR   MGI; MGI:1913904; Tex12.
DR   VEuPathDB; HostDB:ENSMUSG00000032065; -.
DR   eggNOG; ENOG502S8K9; Eukaryota.
DR   GeneTree; ENSGT00390000006602; -.
DR   HOGENOM; CLU_163464_0_0_1; -.
DR   InParanoid; Q9CR81; -.
DR   OMA; RFTMIAN; -.
DR   OrthoDB; 1190337at2759; -.
DR   PhylomeDB; Q9CR81; -.
DR   TreeFam; TF330925; -.
DR   BioGRID-ORCS; 66654; 2 hits in 106 CRISPR screens.
DR   ChiTaRS; Tex12; mouse.
DR   PRO; PR:Q9CR81; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q9CR81; protein.
DR   Bgee; ENSMUSG00000032065; Expressed in spermatocyte and 22 other tissues.
DR   Genevisible; Q9CR81; MM.
DR   GO; GO:0000801; C:central element; IDA:UniProtKB.
DR   GO; GO:0005694; C:chromosome; IDA:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR   GO; GO:0000795; C:synaptonemal complex; IDA:MGI.
DR   GO; GO:0000711; P:meiotic DNA repair synthesis; IMP:MGI.
DR   GO; GO:0007130; P:synaptonemal complex assembly; IMP:MGI.
DR   InterPro; IPR029193; TEX12.
DR   PANTHER; PTHR37349; PTHR37349; 1.
DR   Pfam; PF15219; TEX12; 1.
PE   1: Evidence at protein level;
KW   Chromosome; Meiosis; Reference proteome.
FT   CHAIN           1..123
FT                   /note="Testis-expressed protein 12"
FT                   /id="PRO_0000072494"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..41
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   123 AA;  13958 MW;  14656ECD77A66A00 CRC64;
     MMANHLVKPD SRNCKRAREL EPQVSDSPQV SSLGKSESSL SEASGLFYKE EALEKDLSDM
     SKEINLMLST YAKILSERAA VDASYIDEID GLFKEANIIE NFLVQKREFL KQRFTVITNT
     LHK
 
 
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