TEX15_MOUSE
ID TEX15_MOUSE Reviewed; 2785 AA.
AC F8VPN2; Q3UPQ6; Q3V162; Q99MV3;
DT 17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT 21-SEP-2011, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Testis-expressed protein 15 {ECO:0000250|UniProtKB:Q9BXT5};
GN Name=Tex15 {ECO:0000312|MGI:MGI:1934816};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|Proteomes:UP000000589};
RN [1] {ECO:0000312|EMBL:AAK31968.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Testis {ECO:0000312|EMBL:AAK31968.1};
RX PubMed=11279525; DOI=10.1038/86927;
RA Wang P.J., McCarrey J.R., Yang F., Page D.C.;
RT "An abundance of X-linked genes expressed in spermatogonia.";
RL Nat. Genet. 27:422-426(2001).
RN [2] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000312|EMBL:BAE21290.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1005 (ISOFORM 2), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1086-1789 (ISOFORM 1/2).
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAE21290.1};
RC TISSUE=Ovary {ECO:0000312|EMBL:BAE25339.1}, and
RC Testis {ECO:0000312|EMBL:BAE21290.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=18283110; DOI=10.1083/jcb.200709057;
RA Yang F., Eckardt S., Leu N.A., McLaughlin K.J., Wang P.J.;
RT "Mouse TEX15 is essential for DNA double-strand break repair and
RT chromosomal synapsis during male meiosis.";
RL J. Cell Biol. 180:673-679(2008).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PIWIL2, DISRUPTION
RP PHENOTYPE, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=32381626; DOI=10.1101/gad.335489.119;
RA Yang F., Lan Y., Pandey R.R., Homolka D., Berger S.L., Pillai R.S.,
RA Bartolomei M.S., Wang P.J.;
RT "TEX15 associates with MILI and silences transposable elements in male germ
RT cells.";
RL Genes Dev. 34:745-750(2020).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PIWIL4, DISRUPTION
RP PHENOTYPE, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=32719317; DOI=10.1038/s41467-020-17372-5;
RA Schoepp T., Zoch A., Berrens R.V., Auchynnikava T., Kabayama Y.,
RA Vasiliauskaite L., Rappsilber J., Allshire R.C., O'Carroll D.;
RT "TEX15 is an essential executor of MIWI2-directed transposon DNA
RT methylation and silencing.";
RL Nat. Commun. 11:3739-3739(2020).
CC -!- FUNCTION: Required during spermatogenesis for normal chromosome
CC synapsis and meiotic recombination in germ cells. Necessary for
CC formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a
CC specific role in DNA double-stranded break repair (PubMed:18283110).
CC Essential executor of PIWIL4-piRNA pathway directed transposon DNA
CC methylation and silencing in the male embryonic germ cells
CC (PubMed:32381626, PubMed:32719317). PIWIL4-piRNA binds to nascent
CC transposon transcripts and interacts with TEX15, which may in turn
CC recruit the epigenetic silencing machinery to the transposon loci
CC (PubMed:32381626). Not required for piRNA biosynthesis
CC (PubMed:32381626, PubMed:32719317). {ECO:0000269|PubMed:18283110,
CC ECO:0000269|PubMed:32381626, ECO:0000269|PubMed:32719317}.
CC -!- SUBUNIT: Interacts with PIWIL4 (PubMed:32719317). Interacts with PIWIL2
CC (PubMed:32381626). {ECO:0000269|PubMed:32381626,
CC ECO:0000269|PubMed:32719317}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18283110,
CC ECO:0000269|PubMed:32381626}. Nucleus {ECO:0000269|PubMed:18283110,
CC ECO:0000269|PubMed:32381626, ECO:0000269|PubMed:32719317}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000305};
CC IsoId=F8VPN2-1; Sequence=Displayed;
CC Name=2 {ECO:0000305};
CC IsoId=F8VPN2-2; Sequence=VSP_058101;
CC -!- TISSUE SPECIFICITY: Detected in testis and ovary, and at lower levels
CC in lung and brain. {ECO:0000269|PubMed:11279525,
CC ECO:0000269|PubMed:32381626, ECO:0000269|PubMed:32719317}.
CC -!- DEVELOPMENTAL STAGE: Highly expressed in embryonic male germ cells at
CC embryonic days 16.5 dpc and 18.5 dpc and expression increases at
CC postnatal day 2.5. {ECO:0000269|PubMed:32381626,
CC ECO:0000269|PubMed:32719317}.
CC -!- DISRUPTION PHENOTYPE: Viable with no gross phenotype. Male mice are
CC infertile with significantly reduced testis size, while females are
CC fertile. Severe depletion of germ cells in seminiferous tubules and
CC epididymal tubules, due to meiotic arrest (PubMed:18283110,
CC PubMed:32381626, PubMed:32719317). Male germ cells show derepression of
CC transposable elements (TEs) and severe DNA hypomethylation of TEs
CC (PubMed:32381626, PubMed:32719317). {ECO:0000269|PubMed:18283110,
CC ECO:0000269|PubMed:32381626, ECO:0000269|PubMed:32719317}.
CC -!- SIMILARITY: Belongs to the TEX15 family. {ECO:0000305}.
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DR EMBL; AF285589; AAK31968.1; -; mRNA.
DR EMBL; AC117807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC139025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK132667; BAE21290.1; -; mRNA.
DR EMBL; AK143304; BAE25339.1; -; mRNA.
DR CCDS; CCDS22232.1; -. [F8VPN2-1]
DR RefSeq; NP_113551.2; NM_031374.2. [F8VPN2-1]
DR STRING; 10090.ENSMUSP00000009772; -.
DR iPTMnet; F8VPN2; -.
DR PhosphoSitePlus; F8VPN2; -.
DR PaxDb; F8VPN2; -.
DR PRIDE; F8VPN2; -.
DR ProteomicsDB; 262876; -. [F8VPN2-1]
DR ProteomicsDB; 262877; -. [F8VPN2-2]
DR Antibodypedia; 51904; 18 antibodies from 11 providers.
DR DNASU; 104271; -.
DR Ensembl; ENSMUST00000009772; ENSMUSP00000009772; ENSMUSG00000009628. [F8VPN2-1]
DR GeneID; 104271; -.
DR KEGG; mmu:104271; -.
DR UCSC; uc009lkc.1; mouse. [F8VPN2-1]
DR CTD; 56154; -.
DR MGI; MGI:1934816; Tex15.
DR VEuPathDB; HostDB:ENSMUSG00000009628; -.
DR eggNOG; ENOG502QW6W; Eukaryota.
DR GeneTree; ENSGT00390000006260; -.
DR HOGENOM; CLU_000620_0_0_1; -.
DR InParanoid; F8VPN2; -.
DR OMA; YAWCVYH; -.
DR OrthoDB; 4693at2759; -.
DR TreeFam; TF332375; -.
DR BioGRID-ORCS; 104271; 2 hits in 78 CRISPR screens.
DR ChiTaRS; Tex15; mouse.
DR PRO; PR:F8VPN2; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; F8VPN2; protein.
DR Bgee; ENSMUSG00000009628; Expressed in spermatid and 128 other tissues.
DR ExpressionAtlas; F8VPN2; baseline and differential.
DR Genevisible; F8VPN2; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006306; P:DNA methylation; IMP:UniProtKB.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0009566; P:fertilization; IMP:MGI.
DR GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; IMP:MGI.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IMP:MGI.
DR GO; GO:0030539; P:male genitalia development; IMP:MGI.
DR GO; GO:0007140; P:male meiotic nuclear division; IMP:MGI.
DR GO; GO:0010529; P:negative regulation of transposition; IMP:UniProtKB.
DR GO; GO:0034502; P:protein localization to chromosome; IMP:MGI.
DR GO; GO:0010569; P:regulation of double-strand break repair via homologous recombination; IMP:MGI.
DR GO; GO:0032880; P:regulation of protein localization; IMP:MGI.
DR GO; GO:0007283; P:spermatogenesis; IMP:MGI.
DR GO; GO:0007130; P:synaptonemal complex assembly; IMP:MGI.
DR InterPro; IPR026616; TEX15.
DR InterPro; IPR032765; TEX15_dom.
DR PANTHER; PTHR22380; PTHR22380; 1.
DR Pfam; PF15326; TEX15; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Differentiation; DNA damage; DNA repair;
KW Meiosis; Nucleus; Reference proteome; RNA-mediated gene silencing;
KW Spermatogenesis.
FT CHAIN 1..2785
FT /note="Testis-expressed protein 15"
FT /id="PRO_0000435484"
FT REGION 262..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 904..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 943..1064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2276..2458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2470..2511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2571..2601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..615
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..1001
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1002..1016
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1051
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2276..2342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2349..2456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2478..2503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..10
FT /note="MTYFFIYVST -> MDAEASAGKKFTIPKIRRTTEKVYLSSCYTNTREYGFI
FT HGTLKQCRLDMSCDLQFTWQFGETKLVRNEYLEKQFAAKRSEMREGGRHSRELEEHFCF
FT LALPQADVMDVYQNGLSVGTSPLRILGNPLLGVYLCRHVDIALSHACSRSVAVESIMIF
FT KVLFGRIKKIQPSMDKNKVSLDPSPNFDCHMSRNMPSLKDTIELQAYNSMVYFYEYDYF
FT SRPVDKPRQCLPYAIVTVKCIGQKAGNGQLITSLRFSSTGFPKRL (in isoform
FT 2)"
FT /id="VSP_058101"
FT CONFLICT 693
FT /note="S -> T (in Ref. 1; AAK31968)"
FT /evidence="ECO:0000305"
FT CONFLICT 792
FT /note="A -> G (in Ref. 1; AAK31968)"
FT /evidence="ECO:0000305"
FT CONFLICT 1169
FT /note="K -> R (in Ref. 1; AAK31968)"
FT /evidence="ECO:0000305"
FT CONFLICT 1826
FT /note="L -> P (in Ref. 1; AAK31968)"
FT /evidence="ECO:0000305"
FT CONFLICT 1939
FT /note="R -> S (in Ref. 1; AAK31968)"
FT /evidence="ECO:0000305"
FT CONFLICT 2589
FT /note="P -> L (in Ref. 1; AAK31968)"
FT /evidence="ECO:0000305"
FT CONFLICT 2626
FT /note="T -> P (in Ref. 1; AAK31968)"
FT /evidence="ECO:0000305"
FT CONFLICT 2678
FT /note="A -> T (in Ref. 1; AAK31968)"
FT /evidence="ECO:0000305"
FT CONFLICT 2765
FT /note="A -> V (in Ref. 1; AAK31968)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2785 AA; 311280 MW; 0A9D67F7B91591D2 CRC64;
MTYFFIYVST ERACSLNNCT IAKRIGKGKD ATVIFEHFRK PVDPFVQENC PCKALNSEMG
PFSSDTSSSY GNVQNGNNSV LEAYNRQTEN SSNLRDASQV YTHNSGFSFI PTGNTASGNG
DLFSVTYLRS ILSSISAAFP SHNNTGSSTV ITSKLIKDPR LMKREQSMRN KSDTAGLSDV
LPLDKSLGCG DSQIKLTCMP TSSISSSEVP ADNTITSCLN ASCFKFSSES SHYQAHNSSS
KGHDCIASSS IAVTEQFKEQ HSSSFPSSLS NAFSDVRKQK HSEEQVQRAQ MRSNVPVLTA
LSSESRNSDE SENTCSNDSQ GHFSQESPSS DINSIYKVGH QMSTVFPAQK KGNLCEYIQD
TGMMRASIST EDSTKDGVNH TWCKETVLSN ETVSSPIDNS NTLYQEHKEG GNLNSLSGNC
EKIGVTHKLQ VPKFPISSTG DKNELYRAAL ELECSLTPTI ECLSQKYPQH SLEHEDNTNF
AMTQGLIELK TVQNNQNFGN ILSDAFQEAK DVPLASEKLI DRVISSAAID ISLDSSVCNI
IGEYTCVRRE NENGEASPYN CHKEEASRVK DGVQDHSLSY DAELSCDLNL KINLQEQRDD
KNPNEAKEHN TDNINGSEKQ DCLANDHFTN IVEMREIKSN TEVEILNSEE CFTFNSFRGK
NGKPAETASS ESEAVEQRHA PNDQRGLEHL VSSFPEIEGS SVCVASNATK QIVGTTVLTV
STSLGDHQKD ELKEICSSES SDLGLVKHSI SECEIDTDKD KLQDFHQLVN ENSALKTGLG
SEIEVDLEHD NASVFQQNMH SQGNDLCEEF ELYESLKSRI DWEGLFGSSY EEIESSSFAR
REGTDQHSST ECNCVSFCSQ DKRELHNPIF LPDLQVTITN LLSLRISPTD ESLELKDNFY
KQVTESTEPE TNKEGNASGF GMCSQPSGEN SSFSCANKFG NSVQESGDVS KSESSHSSNS
SHNTHVDQGS GKPNNDSLST EPSNVTVMND KSKCPTKSKP VFNDTRNKKD MQSRSSKRTL
HASSSRGQNI ANKDLREHET HEKKRRPTSH GSSDRFSSLS QGRIKTFSQS EKHIRNVLNI
LNNEASLCKS KHLSRKLNKA VLHLKKAHRR VHTSLQLISK VGQKRKGPLP KAYAVIHNNF
WESCDHQGDS LMSERRYSKH FLSKRKYDKQ GDKRFLRFDI EESLTPVSKH RLYRTNRERI
AECLSNEVMS GHVSSSLTTF HVREFCDEEQ FPEPQLPLAY TSQSISQLEY TNSIVGNESS
SELEHFSETS GNMLDPKETL TEKEYQTHTQ LCNSDSAKLK NHTTHSIRDI AKECNSEDKT
VLCESNPVYL SFIKENTSHS PDKSYDSNCK ANTDIHISVL GSKKKHILSV DIYEQDNCVS
DGVKSGEAIF PIEKCTVPME TTSSIPTENI ASKSYTIPPV SSILVTAGEE ESSVGENGLF
DVNENEMNIT MHSKLDLTSV TEESKICKKN MKNLSCNDSS MLLKENITGP SKRYMAKYIE
EEKIRKIEQA VYKKIITEGS PISFKYKSQN KILKEKSFHV NKKIITNNLT DSHLSIKNST
VDTIALKDIP NQLKERKEAG QIKVNNNSHS DCLSKPAIVE TNHRPVLHGN PKVATLQKEL
KEHRSPNYTS HVTELSQILQ RADEAASLQI LEEETKLCQN ILPLFVQAFE RQQECSIDQI
LISRKLLVEQ NLWNNCRLKL KPCAVDTWVE LQMAMETIQF IENKKRFLEG KPTFRSLLWY
DESLYSELLR RPRGYQLQSN FYPGFQGRLK YNAFCELQNY HNQLVEFLTE TKKENNSYYA
LLKYKRQINE CEAIMKHYSD CFDFCLSVPF ACGVNFGDSL GDLETLRKST LKLISVPGGS
PKVHSYPGKK DHLWIIIEIV SSKVSFIKSN EEISIKICLY GLEHIYFDAA KSLVWKEKSC
SLPKKHSEKN REMEEINERA FSKLKKIYDV LSKGLNNEPT SIGLQEDAII ASKQSTLGSI
SNCRLNKAWL SYPDISCVGE ILDQAKSADL EELQGLTLRC TDHLEILKKY FQMLQEDNID
NIFIMEENVL DMLSNHNLGA VILKPEAIEI YIEIVMISET IHYLKNLIAK KLHNQRFRGM
LWFDWSLLPE LIGCQEEVVS LSVGDTQTHC LWKLVETAIS VLKKELAVIY EYGEASNCSY
ALHLFYRELK ELTGVKRLLN NSKYSVSTYI DLVPHTASVN FGNTVAELEH NYKQFFLLLK
NVMSVPQKDF GKMVHIIKVM KTIEHMKLLS AKDTKLSTHL LFLQMLRNKR NALQQNRQEK
METPVTEPGE DSSQPGVSEQ TPPGTECTVK NISDSSKKRP VTADTCEVSQ GKGNTDTVPS
WKKQKVTMKD VGNIQTVSKH PSTTGSPPND ENKIGSNSSD SLKSISASPE VVKRQSSVLG
SVSPAESVQD TCTPKSESKV EPTDSLPDSL ASLTEQQENS NVIEKRNGNS SVAETNDKKD
CPLVTCDQKD IDASYSPDHT PAQESHKTPV DHTQISPSNL TAGNDDPLVP DASLLSVSAS
QSEKDVYLSG TDFHHENNKI LNLSTEDCTG TSSPEPVCIK DKISVLQVDK TQPIKSESPK
KSMTDAPNPN TAPFGSYGNS ALNVNGTVQH THSEQNSKVL TQKVGTSRNI PPQSACSPVH
NSSAHSFGTS YPYYSWCFYQ YSSSNGTAVT HTYQGMTAYE IQQPPPPVLT TVASTVQSTH
FNRSYSEHFS YFPGQPQANS FNPGNGYFPS HTPVSYNYQQ PVYSQFASHQ PVPQATYPYP
PNPGAPPQVP WTYAPWQQNP FLRRP
