TEX1_YEAST
ID TEX1_YEAST Reviewed; 422 AA.
AC P53851; D6W0U0;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Protein TEX1;
DE AltName: Full=Trex component 1;
GN Name=TEX1; OrderedLocusNames=YNL253W; ORFNames=N0860;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=9234673;
RX DOI=10.1002/(sici)1097-0061(199707)13:9<849::aid-yea106>3.0.co;2-n;
RA Sen-Gupta M., Gueldener U., Beinhauer J.D., Fiedler T.A., Hegemann J.H.;
RT "Sequence analysis of the 33 kb long region between ORC5 and SUI1 from the
RT left arm of chromosome XIV from Saccharomyces cerevisiae.";
RL Yeast 13:849-860(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169873;
RA Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT evolutionary implications.";
RL Nature 387:93-98(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP IDENTIFICATION IN TREX COMPLEX, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=11979277; DOI=10.1038/nature746;
RA Straesser K., Masuda S., Mason P., Pfannstiel J., Oppizzi M.,
RA Rodriguez-Navarro S., Rondon A.G., Aguilera A., Struhl K., Reed R.,
RA Hurt E.;
RT "TREX is a conserved complex coupling transcription with messenger RNA
RT export.";
RL Nature 417:304-308(2002).
CC -!- FUNCTION: Component the TREX complex, which operates in coupling
CC transcription elongation to mRNA export.
CC -!- SUBUNIT: Component of the transcription/export (TREX) complex, which is
CC at least is formed of SUB2, TEX1 and YRA1 and the THO complex composed
CC of HPR1, MFT1, THO2 and THP1. {ECO:0000269|PubMed:11979277}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; Z71529; CAA96160.1; -; Genomic_DNA.
DR EMBL; X96722; CAA65491.1; -; Genomic_DNA.
DR EMBL; AY558028; AAS56354.1; -; Genomic_DNA.
DR EMBL; BK006947; DAA10306.1; -; Genomic_DNA.
DR PIR; S63226; S63226.
DR RefSeq; NP_014146.1; NM_001183091.1.
DR PDB; 7APX; EM; 3.40 A; E=1-380.
DR PDB; 7AQO; EM; 4.50 A; E/K=1-380.
DR PDBsum; 7APX; -.
DR PDBsum; 7AQO; -.
DR AlphaFoldDB; P53851; -.
DR SMR; P53851; -.
DR BioGRID; 35586; 72.
DR ComplexPortal; CPX-1792; THO complex.
DR ComplexPortal; CPX-1793; TREX complex.
DR DIP; DIP-2820N; -.
DR IntAct; P53851; 9.
DR MINT; P53851; -.
DR STRING; 4932.YNL253W; -.
DR CarbonylDB; P53851; -.
DR iPTMnet; P53851; -.
DR MaxQB; P53851; -.
DR PaxDb; P53851; -.
DR PRIDE; P53851; -.
DR EnsemblFungi; YNL253W_mRNA; YNL253W; YNL253W.
DR GeneID; 855468; -.
DR KEGG; sce:YNL253W; -.
DR SGD; S000005197; TEX1.
DR VEuPathDB; FungiDB:YNL253W; -.
DR eggNOG; KOG4155; Eukaryota.
DR HOGENOM; CLU_041466_0_0_1; -.
DR InParanoid; P53851; -.
DR OMA; YWLAYST; -.
DR BioCyc; YEAST:G3O-33250-MON; -.
DR PRO; PR:P53851; -.
DR Proteomes; UP000002311; Chromosome XIV.
DR RNAct; P53851; protein.
DR GO; GO:0000445; C:THO complex part of transcription export complex; IBA:GO_Central.
DR GO; GO:0000346; C:transcription export complex; IDA:SGD.
DR GO; GO:0003729; F:mRNA binding; HDA:SGD.
DR GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IC:ComplexPortal.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR040132; Tex1/THOC3.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR22839; PTHR22839; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; WD repeat.
FT CHAIN 1..422
FT /note="Protein TEX1"
FT /id="PRO_0000051482"
FT REPEAT 61..100
FT /note="WD 1"
FT REPEAT 158..197
FT /note="WD 2"
FT REPEAT 207..246
FT /note="WD 3"
FT REPEAT 251..290
FT /note="WD 4"
FT REPEAT 293..332
FT /note="WD 5"
FT REGION 388..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 23..31
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 33..36
FT /evidence="ECO:0007829|PDB:7APX"
FT HELIX 43..52
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 66..71
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 78..85
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 87..91
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 94..99
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 117..119
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 124..131
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 133..142
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 144..147
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 149..156
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 163..168
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 174..182
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 184..188
FT /evidence="ECO:0007829|PDB:7APX"
FT TURN 189..193
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 194..199
FT /evidence="ECO:0007829|PDB:7APX"
FT HELIX 201..205
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 207..209
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 214..217
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 219..227
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 229..231
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 233..237
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 239..241
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 244..249
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 256..261
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 265..275
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 277..281
FT /evidence="ECO:0007829|PDB:7APX"
FT TURN 282..284
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 287..291
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 298..303
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 309..317
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 319..323
FT /evidence="ECO:0007829|PDB:7APX"
FT TURN 324..326
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 329..332
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 337..341
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 344..346
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 348..351
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 353..356
FT /evidence="ECO:0007829|PDB:7APX"
FT STRAND 358..360
FT /evidence="ECO:0007829|PDB:7APX"
FT TURN 373..375
FT /evidence="ECO:0007829|PDB:7APX"
SQ SEQUENCE 422 AA; 47167 MW; B481B305BB01A8A8 CRC64;
MSTIGAVDIL NQKTITSEVA ASVTSKYLQS TFSKGNTSHI EDKRFIHVSS RSHSRFTSTP
ITPNEILSLK FHVSGSSMAY SRMDGSLTVW FIKDASFDKS VEVYIPDCCG SDKLATDLSW
NPTSLNQIAV VSNSSEISLL LINEKSLTAS KLRTLSLGSK TKVNTCLYDP LGNWLLAATK
SEKIYLFDVK KDHSSVCSLN ISDISQEDND VVYSLAWSNG GSHIFIGFKS GYLAILKAKH
GILEVCTKIK AHTGPITEIK MDPWGRNFIT GSIDGNCYVW NMKSLCCELI INDLNSAVTT
LDVCHLGKIL GICTEDEMVY FYDLNSGNLL HSKSLANYKT DPVLKFYPDK SWYIMSGKND
TLSNHFVKNE KNLITYWKDM FDNTMIEKRR KNNGGGNNHN KRTSKNTDRI GKDRPSRFNS
KK
