ID   TEX22_HUMAN             Reviewed;         150 AA.
AC   C9J3V5;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Testis-expressed protein 22;
GN   Name=TEX22;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RA   Li W.B., Gruber C., Jessee J., Polayes D.;
RT   "Full-length cDNA libraries and normalization.";
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA   Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA   Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA   Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA   Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA   Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA   Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA   Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA   Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA   Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA   Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA   Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA   Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA   Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasmic vesicle,
CC       secretory vesicle, acrosome {ECO:0000250}.
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DR   EMBL; BX378619; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AL928654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS53916.1; -.
DR   RefSeq; NP_001182011.1; NM_001195082.1.
DR   RefSeq; XP_006720297.1; XM_006720234.3.
DR   AlphaFoldDB; C9J3V5; -.
DR   BioGRID; 572084; 1.
DR   STRING; 9606.ENSP00000397002; -.
DR   iPTMnet; C9J3V5; -.
DR   PhosphoSitePlus; C9J3V5; -.
DR   BioMuta; TEX22; -.
DR   MassIVE; C9J3V5; -.
DR   PaxDb; C9J3V5; -.
DR   PeptideAtlas; C9J3V5; -.
DR   PRIDE; C9J3V5; -.
DR   Antibodypedia; 74215; 4 antibodies from 4 providers.
DR   Ensembl; ENST00000451127.3; ENSP00000397002.2; ENSG00000226174.7.
DR   GeneID; 647310; -.
DR   KEGG; hsa:647310; -.
DR   MANE-Select; ENST00000451127.3; ENSP00000397002.2; NM_001195082.2; NP_001182011.1.
DR   UCSC; uc001yqw.3; human.
DR   CTD; 647310; -.
DR   GeneCards; TEX22; -.
DR   HGNC; HGNC:40026; TEX22.
DR   HPA; ENSG00000226174; Tissue enhanced (testis).
DR   neXtProt; NX_C9J3V5; -.
DR   OpenTargets; ENSG00000226174; -.
DR   VEuPathDB; HostDB:ENSG00000226174; -.
DR   eggNOG; ENOG502TE8V; Eukaryota.
DR   GeneTree; ENSGT00520000061791; -.
DR   HOGENOM; CLU_1721772_0_0_1; -.
DR   InParanoid; C9J3V5; -.
DR   OMA; QDIVQMV; -.
DR   OrthoDB; 1360154at2759; -.
DR   PhylomeDB; C9J3V5; -.
DR   TreeFam; TF339653; -.
DR   PathwayCommons; C9J3V5; -.
DR   SignaLink; C9J3V5; -.
DR   BioGRID-ORCS; 647310; 8 hits in 1063 CRISPR screens.
DR   ChiTaRS; TEX22; human.
DR   GenomeRNAi; 647310; -.
DR   Pharos; C9J3V5; Tdark.
DR   PRO; PR:C9J3V5; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   RNAct; C9J3V5; protein.
DR   Bgee; ENSG00000226174; Expressed in left testis and 100 other tissues.
DR   ExpressionAtlas; C9J3V5; baseline and differential.
DR   Genevisible; C9J3V5; HS.
DR   GO; GO:0001669; C:acrosomal vesicle; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoplasmic vesicle; Reference proteome.
FT   CHAIN           1..150
FT                   /note="Testis-expressed protein 22"
FT                   /id="PRO_0000410917"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   150 AA;  16880 MW;  3B45D382863930A5 CRC64;
     MDSRKLSPRG KKLESHLSQE HRRPPLGLIA AWGQPSIQSS VQQGLQTQDW VCEPPERRRP
     GRRWSVSIDE RRRLATLGGR ERPGAAGTQL HCRDVVQMVA QLVSEDVDKD VLLPHPLRST
     ESTNAFQAFL ARSAPFWHNA TFEASRSPPS