TEX22_MOUSE
ID TEX22_MOUSE Reviewed; 189 AA.
AC Q9D9U4; Q80ZP5;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Testis-expressed protein 22;
DE AltName: Full=Testis-expressed protein of 22 kDa;
GN Name=Tex22; Synonyms=Tep22;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=BALB/cJ; TISSUE=Testis;
RX PubMed=12359214; DOI=10.1016/s0006-291x(02)02265-9;
RA Neesen J., Hartwich T., Brandhorst G., Aumuller G., Glaser B., Burfeind P.,
RA Mendoza-Lujambio I.;
RT "Tep22, a novel testicular expressed gene, is involved in the biogenesis of
RT the acrosome and the midpiece of the sperm tail.";
RL Biochem. Biophys. Res. Commun. 297:737-748(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12359214}.
CC Cytoplasmic vesicle, secretory vesicle, acrosome
CC {ECO:0000269|PubMed:12359214}. Note=Localizes in the acrosomal region
CC of early elongating spermatids. During late stages of elongating
CC spermatids, no longer detected in the acrosomal region, while it mainly
CC localizes in the cytoplasm. Incorporated into the midpiece of
CC spermatids and is also present in the mitochondrial sheath of mature
CC spermatozoa.
CC -!- TISSUE SPECIFICITY: Mainly expressed in spermatocytes and spermatids in
CC testis. {ECO:0000269|PubMed:12359214}.
CC -!- DEVELOPMENTAL STAGE: First detected in 18-day-old mice (at protein
CC level). {ECO:0000269|PubMed:12359214}.
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DR EMBL; AF522069; AAO12270.1; -; mRNA.
DR EMBL; AK006471; BAB24604.1; -; mRNA.
DR EMBL; AC073562; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC048634; AAH48634.1; -; mRNA.
DR CCDS; CCDS26203.1; -.
DR RefSeq; NP_083657.1; NM_029381.1.
DR RefSeq; XP_006516402.1; XM_006516339.2.
DR RefSeq; XP_006516403.1; XM_006516340.2.
DR AlphaFoldDB; Q9D9U4; -.
DR STRING; 10090.ENSMUSP00000012355; -.
DR PhosphoSitePlus; Q9D9U4; -.
DR PaxDb; Q9D9U4; -.
DR PeptideAtlas; Q9D9U4; -.
DR PRIDE; Q9D9U4; -.
DR ProteomicsDB; 263284; -.
DR Antibodypedia; 74215; 4 antibodies from 4 providers.
DR DNASU; 75671; -.
DR Ensembl; ENSMUST00000012355; ENSMUSP00000012355; ENSMUSG00000012211.
DR Ensembl; ENSMUST00000109729; ENSMUSP00000105351; ENSMUSG00000012211.
DR Ensembl; ENSMUST00000146107; ENSMUSP00000116272; ENSMUSG00000012211.
DR GeneID; 75671; -.
DR KEGG; mmu:75671; -.
DR UCSC; uc007pft.1; mouse.
DR CTD; 647310; -.
DR MGI; MGI:1922921; Tex22.
DR VEuPathDB; HostDB:ENSMUSG00000012211; -.
DR eggNOG; ENOG502TE8V; Eukaryota.
DR GeneTree; ENSGT00520000061791; -.
DR HOGENOM; CLU_1721772_0_0_1; -.
DR InParanoid; Q9D9U4; -.
DR OMA; QDIVQMV; -.
DR OrthoDB; 1360154at2759; -.
DR TreeFam; TF339653; -.
DR BioGRID-ORCS; 75671; 4 hits in 71 CRISPR screens.
DR ChiTaRS; Tex22; mouse.
DR PRO; PR:Q9D9U4; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q9D9U4; protein.
DR Bgee; ENSMUSG00000012211; Expressed in spermatid and 13 other tissues.
DR ExpressionAtlas; Q9D9U4; baseline and differential.
DR Genevisible; Q9D9U4; MM.
DR GO; GO:0001669; C:acrosomal vesicle; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoplasmic vesicle; Reference proteome.
FT CHAIN 1..189
FT /note="Testis-expressed protein 22"
FT /id="PRO_0000410918"
FT REGION 1..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 11
FT /note="K -> R (in Ref. 4; AAH48634)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 189 AA; 21502 MW; BFBCD69549F92592 CRC64;
MDSRQQRPQR KTLQWQLAQE QRQQSPPQGL AVASSQPDTK SKPQDDLQTQ DWVCEPQELR
RPGSRWNISI DERRRLALQR MQERTDTARA PSGDPLGLHP EGQQTETSPS TQSVPTPPLQ
ACETMADPLQ DIAHVLAELM SEGVERDVLI SQPLRSTENS NAFQDFLAQD APLWKDENFE
AQTSRWPHS
