TEX24_MOUSE
ID TEX24_MOUSE Reviewed; 351 AA.
AC Q5DP50;
DT 17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Protein Tex24 {ECO:0000305};
DE AltName: Full=Testis-expressed protein 24 {ECO:0000312|MGI:MGI:1921539};
DE AltName: Full=Testis-specific factor 1 {ECO:0000303|PubMed:16343427};
GN Name=Tex24 {ECO:0000312|MGI:MGI:1921539};
GN Synonyms=TESF-1 {ECO:0000303|PubMed:16343427};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAT36321.1}
RP NUCLEOTIDE SEQUENCE [MRNA], PUTATIVE FUNCTION, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RC STRAIN=BALB/cJ {ECO:0000312|EMBL:AAT36321.1};
RC TISSUE=Testis {ECO:0000312|EMBL:AAT36321.1};
RX PubMed=16343427; DOI=10.1016/j.bbrc.2005.11.152;
RA Fan J., Graham M., Akabane H., Richardson L.L., Zhu G.Z.;
RT "Identification of a novel male germ cell-specific gene TESF-1 in mice.";
RL Biochem. Biophys. Res. Commun. 340:8-12(2006).
RN [2] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000312|EMBL:AAI39072.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Nuclear factor which might have a role in spermatogenesis.
CC {ECO:0000305|PubMed:16343427}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16343427}.
CC -!- TISSUE SPECIFICITY: Specific to testis, where it is expressed in
CC spermatogonia. {ECO:0000269|PubMed:16343427}.
CC -!- DEVELOPMENTAL STAGE: Detected in testis from postnatal day 20 onwards.
CC {ECO:0000269|PubMed:16343427}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY552600; AAT36321.1; -; mRNA.
DR EMBL; AC102544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC139071; AAI39072.1; -; mRNA.
DR EMBL; BC139072; AAI39073.1; -; mRNA.
DR CCDS; CCDS22215.1; -.
DR RefSeq; NP_001013627.1; NM_001013609.2.
DR RefSeq; XP_006509234.1; XM_006509171.2.
DR AlphaFoldDB; Q5DP50; -.
DR STRING; 10090.ENSMUSP00000093021; -.
DR iPTMnet; Q5DP50; -.
DR PhosphoSitePlus; Q5DP50; -.
DR PaxDb; Q5DP50; -.
DR PRIDE; Q5DP50; -.
DR ProteomicsDB; 259006; -.
DR DNASU; 541463; -.
DR Ensembl; ENSMUST00000095375; ENSMUSP00000093021; ENSMUSG00000071138.
DR GeneID; 541463; -.
DR KEGG; mmu:541463; -.
DR UCSC; uc009lir.1; mouse.
DR CTD; 541463; -.
DR MGI; MGI:1921539; Tex24.
DR VEuPathDB; HostDB:ENSMUSG00000071138; -.
DR GeneTree; ENSGT00520000061098; -.
DR HOGENOM; CLU_789783_0_0_1; -.
DR InParanoid; Q5DP50; -.
DR OMA; ERNIARP; -.
DR OrthoDB; 1186441at2759; -.
DR BioGRID-ORCS; 541463; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q5DP50; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q5DP50; protein.
DR Bgee; ENSMUSG00000071138; Expressed in seminiferous tubule of testis and 19 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR PANTHER; PTHR10026; PTHR10026; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome.
FT CHAIN 1..351
FT /note="Protein Tex24"
FT /id="PRO_0000435468"
FT REGION 69..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 351 AA; 38993 MW; 57BAF253A68FA048 CRC64;
MGSQSLNSTF LKVRRLSLIS SNERLLGQTS GLATGSRLVT QEVDDLRVIP GSRPDLDDHQ
PQCSLAELPS TAHGKRKPGH LPRLRSSAVK GHAPDPNPSL SIVSKRIFKG ESVIKGPEDR
QTFVGPSGLP KISPKATAGE AQGKKRTMEL LNKARKQEEK VSNLLDIRQL PKQEVFINNT
HPCKKHLKQQ PMSLEEWRRG HLGGDNTGLI SQEPFRCCKR LGKKAQCQLL EVTSLEAEAS
LEVLKRRRRM QAMEMSKKPQ DRGLGQEKAV FLSREKVKPS SHDMHLSTAE RSFKPKSMPK
AEDWDLSVQG TPVVLTVRDH SNVSQAQKHL GCAEIFHSRD GRCTLLKRGG A