TEX28_HUMAN
ID TEX28_HUMAN Reviewed; 410 AA.
AC O15482; B1B1E8; D3DWW5;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Testis-specific protein TEX28;
GN Name=TEX28; Synonyms=CXorf2;
GN and
GN Name=TEX28P1;
GN and
GN Name=TEX28P2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=9268643; DOI=10.1006/geno.1997.4830;
RA Hanna M.C., Platts J.T., Kirkness E.F.;
RT "Identification of a gene within the tandem array of red and green color
RT pigment genes.";
RL Genomics 43:384-386(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC O15482; Q01850: CDR2; NbExp=3; IntAct=EBI-751954, EBI-1181367;
CC O15482; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-751954, EBI-3044087;
CC O15482; Q15323: KRT31; NbExp=3; IntAct=EBI-751954, EBI-948001;
CC O15482; Q9ULS5: TMCC3; NbExp=4; IntAct=EBI-751954, EBI-2800326;
CC O15482; Q8N720: ZNF655; NbExp=3; IntAct=EBI-751954, EBI-625509;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Testis specific.
CC -!- SIMILARITY: Belongs to the TEX28 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U93720; AAB71379.1; -; mRNA.
DR EMBL; Z46936; CAI41959.1; -; Genomic_DNA.
DR EMBL; AC092402; CAI41959.1; JOINED; Genomic_DNA.
DR EMBL; Z68193; CAI43243.1; -; Genomic_DNA.
DR EMBL; AC092402; CAI43243.1; JOINED; Genomic_DNA.
DR EMBL; CH471172; EAW72754.1; -; Genomic_DNA.
DR EMBL; CH471172; EAW72755.1; -; Genomic_DNA.
DR EMBL; BC026183; AAH26183.1; -; mRNA.
DR CCDS; CCDS14744.2; -.
DR RefSeq; NP_001192130.1; NM_001205201.1.
DR RefSeq; NP_001577.1; NM_001586.2.
DR AlphaFoldDB; O15482; -.
DR SMR; O15482; -.
DR BioGRID; 107907; 32.
DR IntAct; O15482; 28.
DR STRING; 9606.ENSP00000478834; -.
DR iPTMnet; O15482; -.
DR PhosphoSitePlus; O15482; -.
DR BioMuta; TEX28; -.
DR EPD; O15482; -.
DR MaxQB; O15482; -.
DR PaxDb; O15482; -.
DR PeptideAtlas; O15482; -.
DR PRIDE; O15482; -.
DR ProteomicsDB; 48687; -.
DR Antibodypedia; 73153; 42 antibodies from 14 providers.
DR DNASU; 1527; -.
DR Ensembl; ENST00000610938.1; ENSP00000479148.1; ENSG00000278057.4.
DR Ensembl; ENST00000617225.4; ENSP00000482010.1; ENSG00000278057.4.
DR Ensembl; ENST00000619903.4; ENSP00000478834.1; ENSG00000278057.4.
DR GeneID; 1527; -.
DR KEGG; hsa:1527; -.
DR MANE-Select; ENST00000617225.5; ENSP00000482010.1; NM_001586.3; NP_001577.1.
DR UCSC; uc033fba.2; human.
DR CTD; 1527; -.
DR DisGeNET; 1527; -.
DR GeneCards; TEX28; -.
DR GeneCards; TEX28P1; -.
DR GeneCards; TEX28P2; -.
DR HGNC; HGNC:2563; TEX28.
DR HGNC; HGNC:33356; TEX28P1.
DR HGNC; HGNC:33357; TEX28P2.
DR HPA; ENSG00000278057; Tissue enriched (testis).
DR MIM; 300092; gene.
DR neXtProt; NX_O15482; -.
DR PharmGKB; PA162405646; -.
DR VEuPathDB; HostDB:ENSG00000278057; -.
DR eggNOG; KOG3850; Eukaryota.
DR GeneTree; ENSGT00940000162843; -.
DR HOGENOM; CLU_019951_0_1_1; -.
DR InParanoid; O15482; -.
DR OMA; LKQNLAC; -.
DR OrthoDB; 1258358at2759; -.
DR PhylomeDB; O15482; -.
DR TreeFam; TF316292; -.
DR PathwayCommons; O15482; -.
DR SignaLink; O15482; -.
DR BioGRID-ORCS; 1527; 9 hits in 588 CRISPR screens.
DR GenomeRNAi; 1527; -.
DR Pharos; O15482; Tdark.
DR PRO; PR:O15482; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; O15482; protein.
DR Bgee; ENSG00000278057; Expressed in left testis and 15 other tissues.
DR Genevisible; O15482; HS.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR017387; Testis-specific_TEX28.
DR InterPro; IPR019394; TEX28/TMCC.
DR PANTHER; PTHR17613; PTHR17613; 1.
DR PANTHER; PTHR17613:SF10; PTHR17613:SF10; 1.
DR Pfam; PF10267; Tmemb_cc2; 2.
DR PIRSF; PIRSF038100; Testis-specific_TEX28; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..410
FT /note="Testis-specific protein TEX28"
FT /id="PRO_0000184594"
FT TRANSMEM 336..358
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 93..128
FT /evidence="ECO:0000255"
FT COILED 185..245
FT /evidence="ECO:0000255"
FT COMPBIAS 10..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 410 AA; 46131 MW; 8E455A761D52A660 CRC64;
MVLKAEHTRS PSATLPSNVP SCRSLSSSED GPSGPSSLAD GGLAHNLQDS VRHRILYLSE
QLRVEKASRD GNTVSYLKLV SKADRHQVPH IQQAFEKVNQ RASATIAQIE HRLHQCHQQL
QELEEGCRPE GLLLMAESDP ANCEPPSEKA LLSEPPEPGG EDGPVNLPHA SRPFILESRF
QSLQQGTCLE TEDVAQQQNL LLQKVKAELE EAKRFHISLQ ESYHSLKERS LTDLQLLLES
LQEEKCRQAL MEEQVNGRLQ GQLNEIYNLK HNLACSEERM AYLSYERAKE IWEITETFKS
RISKLEMLQQ VTQLEAAEHL QSRPPQMLFK FLSPRLSLAT VLLVFVSTLC ACPSSLISSR
LCTCTMLMLI GLGVLAWQRW RAIPATDWQE WVPSRCRLYS KDSGPPADGP
