TEX30_HUMAN
ID TEX30_HUMAN Reviewed; 227 AA.
AC Q5JUR7; Q5JUR8; Q96KZ8;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Testis-expressed protein 30;
GN Name=TEX30; Synonyms=C13orf27;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5JUR7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5JUR7-2; Sequence=VSP_055706, VSP_055707;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH15148.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL157769; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC015148; AAH15148.2; ALT_INIT; mRNA.
DR CCDS; CCDS66578.1; -. [Q5JUR7-2]
DR CCDS; CCDS9503.2; -. [Q5JUR7-1]
DR RefSeq; NP_001273704.1; NM_001286775.1. [Q5JUR7-2]
DR RefSeq; NP_001273705.1; NM_001286776.1.
DR RefSeq; NP_620134.3; NM_138779.4. [Q5JUR7-1]
DR RefSeq; XP_005254154.1; XM_005254097.2. [Q5JUR7-1]
DR RefSeq; XP_011519437.1; XM_011521135.2.
DR RefSeq; XP_016876341.1; XM_017020852.1. [Q5JUR7-1]
DR AlphaFoldDB; Q5JUR7; -.
DR SMR; Q5JUR7; -.
DR BioGRID; 124998; 2.
DR STRING; 9606.ENSP00000365200; -.
DR ChEMBL; CHEMBL2189125; -.
DR ESTHER; human-TEX30; NLS3-Tex30.
DR GlyGen; Q5JUR7; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q5JUR7; -.
DR PhosphoSitePlus; Q5JUR7; -.
DR BioMuta; TEX30; -.
DR DMDM; 74742331; -.
DR EPD; Q5JUR7; -.
DR jPOST; Q5JUR7; -.
DR MassIVE; Q5JUR7; -.
DR MaxQB; Q5JUR7; -.
DR PaxDb; Q5JUR7; -.
DR PeptideAtlas; Q5JUR7; -.
DR PRIDE; Q5JUR7; -.
DR ProteomicsDB; 63288; -. [Q5JUR7-1]
DR ProteomicsDB; 63289; -.
DR Antibodypedia; 25333; 22 antibodies from 9 providers.
DR DNASU; 93081; -.
DR Ensembl; ENST00000376027.5; ENSP00000365195.1; ENSG00000151287.17. [Q5JUR7-2]
DR Ensembl; ENST00000376029.3; ENSP00000365197.3; ENSG00000151287.17. [Q5JUR7-2]
DR Ensembl; ENST00000376032.9; ENSP00000365200.4; ENSG00000151287.17. [Q5JUR7-1]
DR GeneID; 93081; -.
DR KEGG; hsa:93081; -.
DR MANE-Select; ENST00000376032.9; ENSP00000365200.4; NM_138779.5; NP_620134.3.
DR UCSC; uc001vpn.5; human. [Q5JUR7-1]
DR CTD; 93081; -.
DR DisGeNET; 93081; -.
DR GeneCards; TEX30; -.
DR HGNC; HGNC:25188; TEX30.
DR HPA; ENSG00000151287; Group enriched (epididymis, liver, testis).
DR neXtProt; NX_Q5JUR7; -.
DR OpenTargets; ENSG00000151287; -.
DR PharmGKB; PA147358470; -.
DR VEuPathDB; HostDB:ENSG00000151287; -.
DR eggNOG; KOG3253; Eukaryota.
DR GeneTree; ENSGT00940000162655; -.
DR HOGENOM; CLU_2269957_0_0_1; -.
DR InParanoid; Q5JUR7; -.
DR OMA; HWIDKAN; -.
DR PhylomeDB; Q5JUR7; -.
DR TreeFam; TF332335; -.
DR PathwayCommons; Q5JUR7; -.
DR BioGRID-ORCS; 93081; 13 hits in 1083 CRISPR screens.
DR GenomeRNAi; 93081; -.
DR Pharos; Q5JUR7; Tdark.
DR PRO; PR:Q5JUR7; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q5JUR7; protein.
DR Bgee; ENSG00000151287; Expressed in right testis and 166 other tissues.
DR ExpressionAtlas; Q5JUR7; baseline and differential.
DR Genevisible; Q5JUR7; HS.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002925; Dienelactn_hydro.
DR InterPro; IPR026555; NSL3/Tex30.
DR PANTHER; PTHR13136; PTHR13136; 1.
DR Pfam; PF01738; DLH; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..227
FT /note="Testis-expressed protein 30"
FT /id="PRO_0000274312"
FT VAR_SEQ 100..113
FT /note="GRSMGSRAAASVMC -> ELVGESGTENASSP (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_055706"
FT VAR_SEQ 114..227
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_055707"
SQ SEQUENCE 227 AA; 25585 MW; B37C06A38A91E774 CRC64;
MSHTEVKLKI PFGNKLLDAV CLVPNKSLTY GIILTHGASG DMNLPHLMSL ASHLASHGFF
CLRFTCKGLN IVHRIKAYKS VLNYLKTSGE YKLAGVFLGG RSMGSRAAAS VMCHIEPDDG
DDFVRGLICI SYPLHHPKQQ HKLRDEDLFR LKEPVLFVSG SADEMCEKNL LEKVAQKMQA
PHKIHWIEKA NHSMAVKGRS TNDVFKEINT QILFWIQEIT EMDKKCH
