TEX33_HUMAN
ID TEX33_HUMAN Reviewed; 280 AA.
AC O43247; B1AH46; Q6ICF2; Q8IVQ2; Q9Y4V8;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Testis-expressed protein 33;
GN Name=TEX33; Synonyms=C22orf33, EAN57;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 212-249.
RA Fiedler W.;
RL Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC O43247-2; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-12093053, EBI-11530605;
CC O43247-2; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-12093053, EBI-10175300;
CC O43247-2; O43186: CRX; NbExp=3; IntAct=EBI-12093053, EBI-748171;
CC O43247-2; Q15323: KRT31; NbExp=3; IntAct=EBI-12093053, EBI-948001;
CC O43247-2; Q9Y6D9: MAD1L1; NbExp=3; IntAct=EBI-12093053, EBI-742610;
CC O43247-2; P50221: MEOX1; NbExp=3; IntAct=EBI-12093053, EBI-2864512;
CC O43247-2; P36406: TRIM23; NbExp=3; IntAct=EBI-12093053, EBI-740098;
CC O43247-2; P14373: TRIM27; NbExp=3; IntAct=EBI-12093053, EBI-719493;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O43247-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O43247-2; Sequence=VSP_028351;
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA72029.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CR456416; CAG30302.1; -; mRNA.
DR EMBL; Z73420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z82180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471095; EAW60128.1; -; Genomic_DNA.
DR EMBL; BC042635; AAH42635.1; -; mRNA.
DR EMBL; Y11142; CAA72029.1; ALT_SEQ; Genomic_DNA.
DR CCDS; CCDS13937.1; -. [O43247-2]
DR CCDS; CCDS54524.1; -. [O43247-1]
DR RefSeq; NP_001157329.1; NM_001163857.1. [O43247-1]
DR RefSeq; NP_848647.1; NM_178552.3. [O43247-2]
DR RefSeq; XP_011528467.1; XM_011530165.2. [O43247-1]
DR RefSeq; XP_011528468.1; XM_011530166.1. [O43247-2]
DR AlphaFoldDB; O43247; -.
DR BioGRID; 130916; 21.
DR IntAct; O43247; 17.
DR STRING; 9606.ENSP00000386118; -.
DR iPTMnet; O43247; -.
DR PhosphoSitePlus; O43247; -.
DR BioMuta; TEX33; -.
DR MassIVE; O43247; -.
DR PaxDb; O43247; -.
DR PeptideAtlas; O43247; -.
DR PRIDE; O43247; -.
DR ProteomicsDB; 48824; -. [O43247-1]
DR ProteomicsDB; 48825; -. [O43247-2]
DR Antibodypedia; 207; 70 antibodies from 17 providers.
DR DNASU; 339669; -.
DR Ensembl; ENST00000381821.2; ENSP00000371243.1; ENSG00000185264.12. [O43247-1]
DR Ensembl; ENST00000402860.7; ENSP00000385179.3; ENSG00000185264.12. [O43247-2]
DR Ensembl; ENST00000405091.6; ENSP00000386118.2; ENSG00000185264.12. [O43247-1]
DR GeneID; 339669; -.
DR KEGG; hsa:339669; -.
DR MANE-Select; ENST00000381821.2; ENSP00000371243.1; NM_001163857.2; NP_001157329.1.
DR UCSC; uc003aqe.4; human. [O43247-1]
DR CTD; 339669; -.
DR DisGeNET; 339669; -.
DR GeneCards; TEX33; -.
DR HGNC; HGNC:28568; TEX33.
DR HPA; ENSG00000185264; Tissue enriched (testis).
DR neXtProt; NX_O43247; -.
DR OpenTargets; ENSG00000185264; -.
DR PharmGKB; PA162378965; -.
DR VEuPathDB; HostDB:ENSG00000185264; -.
DR eggNOG; ENOG502S4AW; Eukaryota.
DR GeneTree; ENSGT00390000013198; -.
DR HOGENOM; CLU_086691_0_0_1; -.
DR InParanoid; O43247; -.
DR OMA; WKTTCSS; -.
DR OrthoDB; 1431133at2759; -.
DR PhylomeDB; O43247; -.
DR TreeFam; TF335904; -.
DR PathwayCommons; O43247; -.
DR SignaLink; O43247; -.
DR BioGRID-ORCS; 339669; 11 hits in 1067 CRISPR screens.
DR ChiTaRS; TEX33; human.
DR GenomeRNAi; 339669; -.
DR Pharos; O43247; Tdark.
DR PRO; PR:O43247; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; O43247; protein.
DR Bgee; ENSG00000185264; Expressed in right testis and 52 other tissues.
DR ExpressionAtlas; O43247; baseline and differential.
DR Genevisible; O43247; HS.
DR InterPro; IPR029234; TEX33.
DR PANTHER; PTHR31702; PTHR31702; 1.
DR Pfam; PF15400; TEX33; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..280
FT /note="Testis-expressed protein 33"
FT /id="PRO_0000086902"
FT REGION 1..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..85
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028351"
SQ SEQUENCE 280 AA; 30725 MW; 45647FA2FE223123 CRC64;
MELGHGAGTT TFTRAHLNDK EGQQDLDPWK AAYSSLDTSK FKNQGLSSPQ PLPLGASAQG
SSLGQCHLKE IPPPPPTAAS RDSLGMDPQS RSLKNAGSRS SSRENRATSG EGAQPCQGTD
DGPSLGAQDQ RSTPTNQKGS IIPNNIRHKF GSNVVDQLVS EEQAQKAIDE VFEGQKRASS
WPSRTQNPVE ISSVFSDYYD LGYNMRSNLF RGAAEETKSL MKASYTPEVI EKSVRDLEHW
HGRKTDDLGR WHQKNAMNLN LQKALEEKYG ENSKSKSSKY
