TEX35_MOUSE
ID TEX35_MOUSE Reviewed; 207 AA.
AC Q14BK3; Q4KKY9; Q9D9J9;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Testis-expressed protein 35;
DE AltName: Full=Testis-specific conserved protein of 24 kDa;
GN Name=Tex35; Synonyms=Tsc24;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=17077512; DOI=10.1248/bpb.29.2187;
RA Tang A., Yu Z., Gui Y., Guo X., Long Y., Cai Z.;
RT "Identification and characteristics of a novel testis-specific gene, Tsc24,
RT in human and mice.";
RL Biol. Pharm. Bull. 29:2187-2191(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17077512}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q14BK3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q14BK3-2; Sequence=VSP_020742;
CC -!- TISSUE SPECIFICITY: Testis-specific. Expressed during spermatogenesis.
CC {ECO:0000269|PubMed:17077512}.
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DR EMBL; AK006825; BAB24758.1; -; mRNA.
DR EMBL; BC099580; AAH99580.1; -; mRNA.
DR EMBL; BC115790; AAI15791.1; -; mRNA.
DR CCDS; CCDS48407.1; -. [Q14BK3-2]
DR CCDS; CCDS78718.1; -. [Q14BK3-1]
DR RefSeq; NP_001291988.1; NM_001305059.1.
DR RefSeq; NP_001291990.1; NM_001305061.1.
DR RefSeq; NP_001291991.1; NM_001305062.1.
DR RefSeq; NP_001291992.1; NM_001305063.1.
DR RefSeq; NP_082816.1; NM_028540.3.
DR AlphaFoldDB; Q14BK3; -.
DR SMR; Q14BK3; -.
DR STRING; 10090.ENSMUSP00000114092; -.
DR iPTMnet; Q14BK3; -.
DR PhosphoSitePlus; Q14BK3; -.
DR PaxDb; Q14BK3; -.
DR PRIDE; Q14BK3; -.
DR ProteomicsDB; 262764; -. [Q14BK3-1]
DR ProteomicsDB; 262765; -. [Q14BK3-2]
DR GeneID; 73435; -.
DR KEGG; mmu:73435; -.
DR CTD; 84066; -.
DR MGI; MGI:1920685; Tex35.
DR eggNOG; ENOG502RVNR; Eukaryota.
DR InParanoid; Q14BK3; -.
DR OrthoDB; 1400673at2759; -.
DR PhylomeDB; Q14BK3; -.
DR TreeFam; TF337831; -.
DR BioGRID-ORCS; 73435; 1 hit in 57 CRISPR screens.
DR PRO; PR:Q14BK3; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q14BK3; protein.
DR GO; GO:0015630; C:microtubule cytoskeleton; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR InterPro; IPR027874; Tex35.
DR PANTHER; PTHR36860; PTHR36860; 1.
DR Pfam; PF15079; Tsc35; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Nucleus; Reference proteome.
FT CHAIN 1..207
FT /note="Testis-expressed protein 35"
FT /id="PRO_0000251188"
FT COILED 43..79
FT /evidence="ECO:0000255"
FT VAR_SEQ 188
FT /note="G -> GR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020742"
FT CONFLICT 133
FT /note="S -> G (in Ref. 1; BAB24758 and 2; AAH99580)"
FT /evidence="ECO:0000305"
FT CONFLICT 145
FT /note="V -> A (in Ref. 1; BAB24758 and 2; AAH99580)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 207 AA; 24056 MW; 82D9E68B4109E952 CRC64;
MSAKNAELKK TNLKKNYKAV CMEPKLTQIY DFKGFKQEGL LIRKGMTREL KNELREVREQ
LTEKMEEIKQ IKDIMDKDFD KLYEFVEIMK EMQQDMDEKM DVLINNQKNN KLPFQNQAKE
QQKFWQLGKM DKSSQAMITE EPDGVPLACD KNVVPPKPTR NPLESLHPCQ SCCEKCLLCA
LKTNRNQGRP SHHAWVPFSP LSSGAAF
