TEX37_HUMAN
ID TEX37_HUMAN Reviewed; 180 AA.
AC Q96LM6;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Testis-expressed sequence 37 protein;
DE AltName: Full=Testis-specific conserved protein of 21 kDa;
GN Name=TEX37; Synonyms=C2orf51, TSC21;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=17091336; DOI=10.1007/s11033-006-9026-6;
RA Yu Z., Tang A., Gui Y., Guo X., Zhu H., Long Y., Li Z., Cai Z.;
RT "Identification and characteristics of a novel testis-specific gene, Tsc21,
RT in mice and human.";
RL Mol. Biol. Rep. 34:127-134(2007).
RN [6]
RP TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=26168773; DOI=10.1021/acs.jproteome.5b00170;
RA Jumeau F., Com E., Lane L., Duek P., Lagarrigue M., Lavigne R., Guillot L.,
RA Rondel K., Gateau A., Melaine N., Guevel B., Sergeant N., Mitchell V.,
RA Pineau C.;
RT "Human spermatozoa as a model for detecting missing proteins in the context
RT of the chromosome-centric human proteome project.";
RL J. Proteome Res. 14:3606-3620(2015).
CC -!- INTERACTION:
CC Q96LM6; Q9NYG5-2: ANAPC11; NbExp=3; IntAct=EBI-743976, EBI-12224467;
CC Q96LM6; P0C7T5: ATXN1L; NbExp=3; IntAct=EBI-743976, EBI-8624731;
CC Q96LM6; J3KQ12: BSCL2; NbExp=3; IntAct=EBI-743976, EBI-11532900;
CC Q96LM6; Q9UQM7: CAMK2A; NbExp=3; IntAct=EBI-743976, EBI-1383687;
CC Q96LM6; Q99895: CTRC; NbExp=3; IntAct=EBI-743976, EBI-10295404;
CC Q96LM6; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-743976, EBI-3867333;
CC Q96LM6; Q15038: DAZAP2; NbExp=9; IntAct=EBI-743976, EBI-724310;
CC Q96LM6; O60548: FOXD2; NbExp=3; IntAct=EBI-743976, EBI-17282008;
CC Q96LM6; P31274: HOXC9; NbExp=3; IntAct=EBI-743976, EBI-1779423;
CC Q96LM6; Q7L273: KCTD9; NbExp=3; IntAct=EBI-743976, EBI-4397613;
CC Q96LM6; Q96G42: KLHDC7B; NbExp=3; IntAct=EBI-743976, EBI-9478422;
CC Q96LM6; O00505: KPNA3; NbExp=3; IntAct=EBI-743976, EBI-358297;
CC Q96LM6; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-743976, EBI-10176379;
CC Q96LM6; P60329: KRTAP12-4; NbExp=3; IntAct=EBI-743976, EBI-10176396;
CC Q96LM6; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-743976, EBI-11953846;
CC Q96LM6; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-743976, EBI-1048945;
CC Q96LM6; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-743976, EBI-10241353;
CC Q96LM6; A1A580: KRTAP23-1; NbExp=3; IntAct=EBI-743976, EBI-10171734;
CC Q96LM6; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-743976, EBI-3957672;
CC Q96LM6; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-743976, EBI-9996449;
CC Q96LM6; Q3LI66: KRTAP6-2; NbExp=4; IntAct=EBI-743976, EBI-11962084;
CC Q96LM6; P32242: OTX1; NbExp=3; IntAct=EBI-743976, EBI-740446;
CC Q96LM6; Q99697-2: PITX2; NbExp=3; IntAct=EBI-743976, EBI-12138495;
CC Q96LM6; Q53SZ7: PRR30; NbExp=3; IntAct=EBI-743976, EBI-12360827;
CC Q96LM6; Q9NWB1-5: RBFOX1; NbExp=3; IntAct=EBI-743976, EBI-12123390;
CC Q96LM6; O43251-10: RBFOX2; NbExp=3; IntAct=EBI-743976, EBI-11963050;
CC Q96LM6; Q93062: RBPMS; NbExp=4; IntAct=EBI-743976, EBI-740322;
CC Q96LM6; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-743976, EBI-740343;
CC Q96LM6; Q6ZRY4: RBPMS2; NbExp=3; IntAct=EBI-743976, EBI-11987469;
CC Q96LM6; Q7L0R7: RNF44; NbExp=3; IntAct=EBI-743976, EBI-2845060;
CC Q96LM6; O95416: SOX14; NbExp=3; IntAct=EBI-743976, EBI-9087806;
CC Q96LM6; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-743976, EBI-11952651;
CC Q96LM6; Q92734: TFG; NbExp=3; IntAct=EBI-743976, EBI-357061;
CC Q96LM6; Q08117-2: TLE5; NbExp=3; IntAct=EBI-743976, EBI-11741437;
CC Q96LM6; O43711: TLX3; NbExp=3; IntAct=EBI-743976, EBI-3939165;
CC Q96LM6; Q15645: TRIP13; NbExp=7; IntAct=EBI-743976, EBI-358993;
CC Q96LM6; Q5T6F2: UBAP2; NbExp=3; IntAct=EBI-743976, EBI-2514383;
CC Q96LM6; Q08AM6: VAC14; NbExp=3; IntAct=EBI-743976, EBI-2107455;
CC Q96LM6; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-743976, EBI-11957216;
CC Q96LM6; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-743976, EBI-12040603;
CC Q96LM6; A0A0C4DGF1: ZBTB32; NbExp=3; IntAct=EBI-743976, EBI-10188476;
CC Q96LM6; Q96K80: ZC3H10; NbExp=3; IntAct=EBI-743976, EBI-742550;
CC Q96LM6; Q96EJ4; NbExp=3; IntAct=EBI-743976, EBI-750454;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9DAG4}. Cytoplasm
CC {ECO:0000269|PubMed:26168773}. Note=Present in the germ cell lineage at
CC all stages (PubMed:26168773). {ECO:0000269|PubMed:26168773}.
CC -!- TISSUE SPECIFICITY: Testis-specific (PubMed:17091336, PubMed:26168773).
CC Detected in the germ cell lineage at all stages (PubMed:26168773).
CC {ECO:0000269|PubMed:17091336, ECO:0000269|PubMed:26168773}.
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DR EMBL; AK058098; BAB71663.1; -; mRNA.
DR EMBL; AC104134; AAY24330.1; -; Genomic_DNA.
DR EMBL; CH471215; EAW77070.1; -; Genomic_DNA.
DR EMBL; BC029522; AAH29522.1; -; mRNA.
DR CCDS; CCDS2003.1; -.
DR RefSeq; NP_689883.1; NM_152670.2.
DR RefSeq; XP_005264245.3; XM_005264188.3.
DR RefSeq; XP_011530993.1; XM_011532691.1.
DR RefSeq; XP_011530994.1; XM_011532692.1.
DR AlphaFoldDB; Q96LM6; -.
DR SMR; Q96LM6; -.
DR BioGRID; 128332; 49.
DR IntAct; Q96LM6; 43.
DR STRING; 9606.ENSP00000307142; -.
DR iPTMnet; Q96LM6; -.
DR PhosphoSitePlus; Q96LM6; -.
DR BioMuta; TEX37; -.
DR MassIVE; Q96LM6; -.
DR PaxDb; Q96LM6; -.
DR PeptideAtlas; Q96LM6; -.
DR PRIDE; Q96LM6; -.
DR Antibodypedia; 51969; 83 antibodies from 19 providers.
DR DNASU; 200523; -.
DR Ensembl; ENST00000303254.4; ENSP00000307142.3; ENSG00000172073.4.
DR GeneID; 200523; -.
DR KEGG; hsa:200523; -.
DR MANE-Select; ENST00000303254.4; ENSP00000307142.3; NM_152670.3; NP_689883.1.
DR UCSC; uc002stb.3; human.
DR CTD; 200523; -.
DR GeneCards; TEX37; -.
DR HGNC; HGNC:26341; TEX37.
DR HPA; ENSG00000172073; Tissue enriched (testis).
DR MIM; 619676; gene.
DR neXtProt; NX_Q96LM6; -.
DR OpenTargets; ENSG00000172073; -.
DR PharmGKB; PA162379191; -.
DR VEuPathDB; HostDB:ENSG00000172073; -.
DR eggNOG; ENOG502T74N; Eukaryota.
DR GeneTree; ENSGT00390000012177; -.
DR HOGENOM; CLU_132395_0_0_1; -.
DR InParanoid; Q96LM6; -.
DR OMA; SSYMVDY; -.
DR OrthoDB; 1271554at2759; -.
DR PhylomeDB; Q96LM6; -.
DR TreeFam; TF337872; -.
DR PathwayCommons; Q96LM6; -.
DR SignaLink; Q96LM6; -.
DR BioGRID-ORCS; 200523; 11 hits in 1065 CRISPR screens.
DR ChiTaRS; TEX37; human.
DR GenomeRNAi; 200523; -.
DR Pharos; Q96LM6; Tdark.
DR PRO; PR:Q96LM6; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q96LM6; protein.
DR Bgee; ENSG00000172073; Expressed in right testis and 36 other tissues.
DR ExpressionAtlas; Q96LM6; baseline and differential.
DR Genevisible; Q96LM6; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR029361; TEX37.
DR PANTHER; PTHR36882; PTHR36882; 1.
DR Pfam; PF15217; TSC21; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..180
FT /note="Testis-expressed sequence 37 protein"
FT /id="PRO_0000304989"
FT VARIANT 24
FT /note="D -> N (in dbSNP:rs35750657)"
FT /id="VAR_035142"
SQ SEQUENCE 180 AA; 20615 MW; AB9BC8BFE2850E92 CRC64;
MAGVKYPGQD PVDLDIYQSS HMVDYQPYRK HKYSRVTPQE QAKLDAQLRD KEFYRPIPNP
NPKLTDGYPA FKRPHMTAKD LGLPGFFPSQ EHEATREDER KFTSTCHFTY PASHDLHLAQ
GDPNQVLQSA DFPCLVDPKH QPAAEMAKGY LLLPGCPCLH CHIVKVPILN RWGPLMPFYQ
