TEX37_MOUSE
ID TEX37_MOUSE Reviewed; 180 AA.
AC Q9DAG4; Q810N1;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Testis-expressed sequence 37 protein;
DE AltName: Full=Testis-specific conserved protein of 21 kDa;
GN Name=Tex37; Synonyms=Tsc21;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=17091336; DOI=10.1007/s11033-006-9026-6;
RA Yu Z., Tang A., Gui Y., Guo X., Zhu H., Long Y., Li Z., Cai Z.;
RT "Identification and characteristics of a novel testis-specific gene, Tsc21,
RT in mice and human.";
RL Mol. Biol. Rep. 34:127-134(2007).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17091336}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q96LM6}. Note=Present in the germ cell lineage
CC at all stages. {ECO:0000250|UniProtKB:Q96LM6}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9DAG4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9DAG4-2; Sequence=VSP_028172;
CC -!- TISSUE SPECIFICITY: Only detected after the mouse is 35 days old.
CC Expression increases gradually from day 35 to 6 months, and remains
CC stable after 54 days. Exclusively expressed in the epididymis and
CC testis. Not expressed in other tissues. {ECO:0000269|PubMed:17091336}.
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DR EMBL; AK005862; BAB24282.1; -; mRNA.
DR EMBL; BC049736; AAH49736.1; -; mRNA.
DR CCDS; CCDS20224.1; -. [Q9DAG4-1]
DR RefSeq; NP_083101.1; NM_028825.3. [Q9DAG4-1]
DR RefSeq; XP_006506769.1; XM_006506706.2.
DR AlphaFoldDB; Q9DAG4; -.
DR SMR; Q9DAG4; -.
DR STRING; 10090.ENSMUSP00000066786; -.
DR PhosphoSitePlus; Q9DAG4; -.
DR PaxDb; Q9DAG4; -.
DR PRIDE; Q9DAG4; -.
DR ProteomicsDB; 263286; -. [Q9DAG4-1]
DR ProteomicsDB; 263287; -. [Q9DAG4-2]
DR Antibodypedia; 51969; 83 antibodies from 19 providers.
DR Ensembl; ENSMUST00000063456; ENSMUSP00000066786; ENSMUSG00000051896. [Q9DAG4-1]
DR GeneID; 74221; -.
DR KEGG; mmu:74221; -.
DR UCSC; uc009cgd.1; mouse. [Q9DAG4-1]
DR UCSC; uc009cge.1; mouse. [Q9DAG4-2]
DR CTD; 200523; -.
DR MGI; MGI:1921471; Tex37.
DR VEuPathDB; HostDB:ENSMUSG00000051896; -.
DR eggNOG; ENOG502T74N; Eukaryota.
DR GeneTree; ENSGT00390000012177; -.
DR HOGENOM; CLU_132395_0_0_1; -.
DR InParanoid; Q9DAG4; -.
DR OMA; SSYMVDY; -.
DR OrthoDB; 1271554at2759; -.
DR TreeFam; TF337872; -.
DR BioGRID-ORCS; 74221; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Tex37; mouse.
DR PRO; PR:Q9DAG4; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9DAG4; protein.
DR Bgee; ENSMUSG00000051896; Expressed in seminiferous tubule of testis and 15 other tissues.
DR Genevisible; Q9DAG4; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR029361; TEX37.
DR PANTHER; PTHR36882; PTHR36882; 1.
DR Pfam; PF15217; TSC21; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..180
FT /note="Testis-expressed sequence 37 protein"
FT /id="PRO_0000304990"
FT VAR_SEQ 41
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028172"
SQ SEQUENCE 180 AA; 21041 MW; 8D431BB6AF657CAE CRC64;
MARVVRPQKN HVDLDIYQSS YMVDYKPFGK YKYSRVTPQE QAKLDAQLQS KEFYQPKPNP
NPKLEEGYPA FRRPYMTALD LGVPGFFPPQ ERVTTRKDDG RFTTTCHYAY PASLALYLAQ
QDPYWLHQRA DFPCLMEPER QPAPEVGKGY LLLPGCLCDH HQRVKVPILN RWGPLMPFYQ
