TEX38_HUMAN
ID TEX38_HUMAN Reviewed; 206 AA.
AC Q6PEX7; A1A4F8;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 3.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Testis-expressed protein 38;
DE AltName: Full=ATPAF1 antisense RNA 1;
DE AltName: Full=ATPAF1 antisense gene protein 1;
GN Name=TEX38; Synonyms=ATPAF1-AS1, C1orf223;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLU-104 AND VAL-199.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH57818.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI26319.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL593856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC126318; AAI26319.1; ALT_INIT; mRNA.
DR EMBL; BC057818; AAH57818.1; ALT_INIT; mRNA.
DR CCDS; CCDS57999.1; -.
DR RefSeq; NP_001138946.1; NM_001145474.3.
DR AlphaFoldDB; Q6PEX7; -.
DR STRING; 9606.ENSP00000455854; -.
DR iPTMnet; Q6PEX7; -.
DR PhosphoSitePlus; Q6PEX7; -.
DR BioMuta; TEX38; -.
DR DMDM; 317373468; -.
DR MassIVE; Q6PEX7; -.
DR PaxDb; Q6PEX7; -.
DR PeptideAtlas; Q6PEX7; -.
DR PRIDE; Q6PEX7; -.
DR Antibodypedia; 66742; 22 antibodies from 9 providers.
DR DNASU; 374973; -.
DR Ensembl; ENST00000334122.5; ENSP00000455854.1; ENSG00000186118.9.
DR GeneID; 374973; -.
DR KEGG; hsa:374973; -.
DR MANE-Select; ENST00000334122.5; ENSP00000455854.1; NM_001145474.4; NP_001138946.1.
DR UCSC; uc001cqj.4; human.
DR CTD; 374973; -.
DR GeneCards; TEX38; -.
DR HGNC; HGNC:29589; TEX38.
DR HPA; ENSG00000186118; Tissue enriched (testis).
DR neXtProt; NX_Q6PEX7; -.
DR OpenTargets; ENSG00000186118; -.
DR PharmGKB; PA162378937; -.
DR VEuPathDB; HostDB:ENSG00000186118; -.
DR eggNOG; ENOG502SFNG; Eukaryota.
DR GeneTree; ENSGT00390000016446; -.
DR HOGENOM; CLU_092826_0_0_1; -.
DR InParanoid; Q6PEX7; -.
DR OMA; WINKRRH; -.
DR OrthoDB; 1417535at2759; -.
DR PhylomeDB; Q6PEX7; -.
DR PathwayCommons; Q6PEX7; -.
DR BioGRID-ORCS; 374973; 6 hits in 1057 CRISPR screens.
DR GenomeRNAi; 374973; -.
DR Pharos; Q6PEX7; Tdark.
DR PRO; PR:Q6PEX7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q6PEX7; protein.
DR Bgee; ENSG00000186118; Expressed in left testis and 99 other tissues.
DR ExpressionAtlas; Q6PEX7; baseline and differential.
DR Genevisible; Q6PEX7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031677; TEX38.
DR PANTHER; PTHR37362; PTHR37362; 1.
DR Pfam; PF15834; THEG4; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..206
FT /note="Testis-expressed protein 38"
FT /id="PRO_0000322538"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 104
FT /note="D -> E (in dbSNP:rs614486)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_039405"
FT VARIANT 199
FT /note="A -> V (in dbSNP:rs1025806)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_039406"
SQ SEQUENCE 206 AA; 23280 MW; ECA42A11860253B8 CRC64;
MDSQQEDLRF PGMWVSLYFG ILGLCSVITG GCIIFLHWRK NLRREEHAQQ WVEVMRAATF
TYSPLLYWIN KRRRYGMNAA INTGPAPAVT KTETEVQNPD VLWDLDIPEG RSHADQDSNP
KAEAPAPLQP ALQLAPQQPQ ARSPFPLPIF QEVPFAPPLC NLPPLLNHSV SYPLATCPER
NVLFHSLLNL AQEDHSFNAK PFPSEL
