TEX43_MOUSE
ID TEX43_MOUSE Reviewed; 141 AA.
AC Q9D9I1;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 2.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Testis-expressed protein 43;
GN Name=Tex43;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP DISRUPTION PHENOTYPE, AND TISSUE SPECIFICITY.
RX PubMed=34446558; DOI=10.1073/pnas.2106673118;
RA Miyata H., Oura S., Morohoshi A., Shimada K., Mashiko D., Oyama Y.,
RA Kaneda Y., Matsumura T., Abbasi F., Ikawa M.;
RT "SPATA33 localizes calcineurin to the mitochondria and regulates sperm
RT motility in mice.";
RL Proc. Natl. Acad. Sci. U.S.A. 118:0-0(2021).
CC -!- TISSUE SPECIFICITY: Expressed predominantly in the testis.
CC {ECO:0000269|PubMed:34446558}.
CC -!- DISRUPTION PHENOTYPE: No defects seen in the sperm morphology and
CC motility (PubMed:34446558). Velocity parameters such as average path
CC velocity, straight-line velocity, and curvilinear velocity are slightly
CC decreased in the spermatozoa (PubMed:34446558).
CC {ECO:0000269|PubMed:34446558}.
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DR EMBL; AK006893; BAB24783.2; -; mRNA.
DR EMBL; BC099538; AAH99538.1; -; mRNA.
DR CCDS; CCDS29260.1; -.
DR RefSeq; NP_080375.2; NM_026099.3.
DR AlphaFoldDB; Q9D9I1; -.
DR STRING; 10090.ENSMUSP00000038152; -.
DR PaxDb; Q9D9I1; -.
DR PRIDE; Q9D9I1; -.
DR ProteomicsDB; 262878; -.
DR Antibodypedia; 51544; 71 antibodies from 10 providers.
DR Ensembl; ENSMUST00000035640; ENSMUSP00000038152; ENSMUSG00000032900.
DR GeneID; 67343; -.
DR KEGG; mmu:67343; -.
DR UCSC; uc008eyr.1; mouse.
DR CTD; 389320; -.
DR MGI; MGI:1914593; Tex43.
DR VEuPathDB; HostDB:ENSMUSG00000032900; -.
DR eggNOG; ENOG502S426; Eukaryota.
DR GeneTree; ENSGT00390000006935; -.
DR HOGENOM; CLU_131594_1_0_1; -.
DR InParanoid; Q9D9I1; -.
DR OMA; PKLANNC; -.
DR OrthoDB; 1515620at2759; -.
DR PhylomeDB; Q9D9I1; -.
DR TreeFam; TF339864; -.
DR BioGRID-ORCS; 67343; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Tex43; mouse.
DR PRO; PR:Q9D9I1; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q9D9I1; protein.
DR Bgee; ENSMUSG00000032900; Expressed in seminiferous tubule of testis and 47 other tissues.
DR ExpressionAtlas; Q9D9I1; baseline and differential.
DR Genevisible; Q9D9I1; MM.
DR GO; GO:0030317; P:flagellated sperm motility; IMP:MGI.
DR InterPro; IPR027965; DUF4513.
DR PANTHER; PTHR35247; PTHR35247; 1.
DR Pfam; PF14983; DUF4513; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..141
FT /note="Testis-expressed protein 43"
FT /id="PRO_0000321825"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 141 AA; 16282 MW; DAF6F88C42E4357B CRC64;
MASEKDDGPA LPKLDDDNQT AENTCKPAEE QPQQLRWDDI HLPRFSLKQG MIPTRYVMPW
KENMKFRNVN LQQAEACGIY AGPLEDSLFW GYSERLCHGE DRKAVLKKGL PEIKITDMPL
HSPLSRYQST VISHGFRRRL I
