TEX44_HUMAN
ID TEX44_HUMAN Reviewed; 395 AA.
AC Q53QW1; Q8N4F2;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Testis-expressed protein 44;
GN Name=TEX44 {ECO:0000312|HGNC:HGNC:28563}; Synonyms=C2orf57;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT PRO-261.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-261.
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=26168773; DOI=10.1021/acs.jproteome.5b00170;
RA Jumeau F., Com E., Lane L., Duek P., Lagarrigue M., Lavigne R., Guillot L.,
RA Rondel K., Gateau A., Melaine N., Guevel B., Sergeant N., Mitchell V.,
RA Pineau C.;
RT "Human spermatozoa as a model for detecting missing proteins in the context
RT of the chromosome-centric human proteome project.";
RL J. Proteome Res. 14:3606-3620(2015).
CC -!- INTERACTION:
CC Q53QW1; P02654: APOC1; NbExp=5; IntAct=EBI-10278496, EBI-1220105;
CC Q53QW1; Q6P1S2: C3orf33; NbExp=3; IntAct=EBI-10278496, EBI-13382270;
CC Q53QW1; Q9UHD4: CIDEB; NbExp=5; IntAct=EBI-10278496, EBI-7062247;
CC Q53QW1; Q5RI15: COX20; NbExp=3; IntAct=EBI-10278496, EBI-2834035;
CC Q53QW1; Q92523: CPT1B; NbExp=6; IntAct=EBI-10278496, EBI-10278486;
CC Q53QW1; Q9BUN8: DERL1; NbExp=3; IntAct=EBI-10278496, EBI-398977;
CC Q53QW1; Q5XKP0: MICOS13; NbExp=3; IntAct=EBI-10278496, EBI-1053887;
CC Q53QW1; O95563: MPC2; NbExp=3; IntAct=EBI-10278496, EBI-719403;
CC Q53QW1; Q6NTF9-3: RHBDD2; NbExp=3; IntAct=EBI-10278496, EBI-17589229;
CC Q53QW1; Q16563: SYPL1; NbExp=3; IntAct=EBI-10278496, EBI-2800683;
CC Q53QW1; O60830: TIMM17B; NbExp=3; IntAct=EBI-10278496, EBI-2372529;
CC Q53QW1; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-10278496, EBI-8638294;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26168773}.
CC -!- TISSUE SPECIFICITY: Testis. Detected in germ cells at all stages of the
CC seminiferous epithelium, strong expression in elongating spermatids (at
CC protein level) (PubMed:26168773). {ECO:0000269|PubMed:26168773}.
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DR EMBL; AC104634; AAY24071.1; -; Genomic_DNA.
DR EMBL; CH471063; EAW70967.1; -; Genomic_DNA.
DR EMBL; BC024251; AAH24251.1; -; mRNA.
DR EMBL; BC034405; AAH34405.1; -; mRNA.
DR EMBL; BC063389; AAH63389.1; -; mRNA.
DR CCDS; CCDS2487.1; -.
DR RefSeq; NP_689827.2; NM_152614.2.
DR AlphaFoldDB; Q53QW1; -.
DR BioGRID; 127908; 13.
DR IntAct; Q53QW1; 13.
DR STRING; 9606.ENSP00000315557; -.
DR iPTMnet; Q53QW1; -.
DR PhosphoSitePlus; Q53QW1; -.
DR BioMuta; TEX44; -.
DR DMDM; 74726496; -.
DR MassIVE; Q53QW1; -.
DR PaxDb; Q53QW1; -.
DR PeptideAtlas; Q53QW1; -.
DR PRIDE; Q53QW1; -.
DR ProteomicsDB; 62512; -.
DR Antibodypedia; 34418; 51 antibodies from 9 providers.
DR DNASU; 165100; -.
DR Ensembl; ENST00000313965.4; ENSP00000315557.2; ENSG00000177673.4.
DR GeneID; 165100; -.
DR KEGG; hsa:165100; -.
DR MANE-Select; ENST00000313965.4; ENSP00000315557.2; NM_152614.3; NP_689827.2.
DR UCSC; uc002vrz.4; human.
DR CTD; 165100; -.
DR GeneCards; TEX44; -.
DR HGNC; HGNC:28563; TEX44.
DR HPA; ENSG00000177673; Tissue enriched (testis).
DR neXtProt; NX_Q53QW1; -.
DR OpenTargets; ENSG00000177673; -.
DR PharmGKB; PA162379291; -.
DR VEuPathDB; HostDB:ENSG00000177673; -.
DR eggNOG; ENOG502TDPT; Eukaryota.
DR GeneTree; ENSGT00390000009950; -.
DR HOGENOM; CLU_038692_0_0_1; -.
DR InParanoid; Q53QW1; -.
DR OMA; VWSETTM; -.
DR OrthoDB; 1047581at2759; -.
DR PhylomeDB; Q53QW1; -.
DR TreeFam; TF338437; -.
DR PathwayCommons; Q53QW1; -.
DR SignaLink; Q53QW1; -.
DR BioGRID-ORCS; 165100; 12 hits in 1034 CRISPR screens.
DR ChiTaRS; C2orf57; human.
DR GenomeRNAi; 165100; -.
DR Pharos; Q53QW1; Tdark.
DR PRO; PR:Q53QW1; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q53QW1; protein.
DR Bgee; ENSG00000177673; Expressed in left testis and 48 other tissues.
DR Genevisible; Q53QW1; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR InterPro; IPR031460; DUF4678.
DR PANTHER; PTHR37365; PTHR37365; 1.
DR Pfam; PF15727; DUF4678; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..395
FT /note="Testis-expressed protein 44"
FT /id="PRO_0000309182"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 46..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 133..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 333
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5U2Y8"
FT VARIANT 11
FT /note="V -> L (in dbSNP:rs16828251)"
FT /id="VAR_036894"
FT VARIANT 79
FT /note="Q -> R (in dbSNP:rs16828254)"
FT /id="VAR_036895"
FT VARIANT 168
FT /note="E -> K (in dbSNP:rs16828257)"
FT /id="VAR_036896"
FT VARIANT 261
FT /note="S -> P (in dbSNP:rs10933378)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_036897"
SQ SEQUENCE 395 AA; 41589 MW; EA2BD81DEC8AD50B CRC64;
MALPGYPLGN VDDSRSKDSP AGEPQGQVPL TADVLAVSSS VASTDWQDID QASFKTATPR
AISTSGDKDK SAVVPEHGQK TPRKITPLLP SQNPSPLQVS MSLQNPAWDR QVQDARTSQS
LVVFPSHLLG KDKMSQMASV PEREPESAPS APSAELQSTQ HMEAQPVESD ADHVTAGANG
QHGPQAASTT KSAEEKAEHP KAPHPEAEAL PSDESPVAMG ANVVDSLGDL QTWFFPPPPA
GSVSPSPGPH EVALGRRPLD SSLYTASEEN SYMRSMTSLL DRGEGSISSL ADILVWSETT
MGMAIATGFL DSGHSTVADL LHSSGPSLRS VPSLVGSVSS AFSSGLVSGT SSALRTITRV
LETVEQRTVE GIRSAMRYLT SHLTPRQAQA DPNYD
