TEX45_HUMAN
ID TEX45_HUMAN Reviewed; 505 AA.
AC Q8NA69; Q8N115;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Testis-expressed protein 45;
GN Name=TEX45 {ECO:0000312|HGNC:HGNC:24745}; Synonyms=C19orf45;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLY-256; ASN-396;
RP ASN-434; SER-497 AND PRO-500.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8NA69; Q9H6L4: ARMC7; NbExp=3; IntAct=EBI-12021638, EBI-742909;
CC Q8NA69; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-12021638, EBI-3867333;
CC Q8NA69; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-12021638, EBI-11750983;
CC Q8NA69; Q9BXF9: TEKT3; NbExp=3; IntAct=EBI-12021638, EBI-8644516;
CC -!- TISSUE SPECIFICITY: Highly expressed in testis. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH29824.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH34779.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK093103; BAC04057.1; -; mRNA.
DR EMBL; AC008878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC029824; AAH29824.1; ALT_INIT; mRNA.
DR EMBL; BC034779; AAH34779.1; ALT_INIT; mRNA.
DR CCDS; CCDS12179.2; -.
DR RefSeq; NP_940936.2; NM_198534.2.
DR RefSeq; XP_005272530.1; XM_005272473.3.
DR AlphaFoldDB; Q8NA69; -.
DR BioGRID; 131928; 22.
DR IntAct; Q8NA69; 18.
DR STRING; 9606.ENSP00000355241; -.
DR iPTMnet; Q8NA69; -.
DR PhosphoSitePlus; Q8NA69; -.
DR BioMuta; TEX45; -.
DR DMDM; 156630490; -.
DR MassIVE; Q8NA69; -.
DR PaxDb; Q8NA69; -.
DR PeptideAtlas; Q8NA69; -.
DR PRIDE; Q8NA69; -.
DR ProteomicsDB; 72648; -.
DR Antibodypedia; 52976; 58 antibodies from 13 providers.
DR DNASU; 374877; -.
DR Ensembl; ENST00000361664.7; ENSP00000355241.2; ENSG00000198723.11.
DR GeneID; 374877; -.
DR KEGG; hsa:374877; -.
DR MANE-Select; ENST00000361664.7; ENSP00000355241.2; NM_198534.3; NP_940936.2.
DR UCSC; uc002mgm.2; human.
DR CTD; 374877; -.
DR DisGeNET; 374877; -.
DR GeneCards; TEX45; -.
DR HGNC; HGNC:24745; TEX45.
DR HPA; ENSG00000198723; Tissue enriched (testis).
DR neXtProt; NX_Q8NA69; -.
DR OpenTargets; ENSG00000198723; -.
DR PharmGKB; PA145149520; -.
DR VEuPathDB; HostDB:ENSG00000198723; -.
DR eggNOG; ENOG502S3A0; Eukaryota.
DR GeneTree; ENSGT00390000014215; -.
DR HOGENOM; CLU_041675_0_0_1; -.
DR InParanoid; Q8NA69; -.
DR OMA; AAAHIHC; -.
DR OrthoDB; 867507at2759; -.
DR PhylomeDB; Q8NA69; -.
DR TreeFam; TF336162; -.
DR PathwayCommons; Q8NA69; -.
DR SignaLink; Q8NA69; -.
DR BioGRID-ORCS; 374877; 10 hits in 1038 CRISPR screens.
DR GenomeRNAi; 374877; -.
DR Pharos; Q8NA69; Tdark.
DR PRO; PR:Q8NA69; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8NA69; protein.
DR Bgee; ENSG00000198723; Expressed in right testis and 121 other tissues.
DR ExpressionAtlas; Q8NA69; baseline and differential.
DR Genevisible; Q8NA69; HS.
DR InterPro; IPR028001; DUF4601.
DR PANTHER; PTHR34828; PTHR34828; 1.
DR Pfam; PF15373; DUF4601; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..505
FT /note="Testis-expressed protein 45"
FT /id="PRO_0000297660"
FT REGION 172..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 256
FT /note="D -> G (in dbSNP:rs484870)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_034664"
FT VARIANT 396
FT /note="Y -> N (in dbSNP:rs3826736)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_034665"
FT VARIANT 434
FT /note="Y -> N (in dbSNP:rs475923)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_034666"
FT VARIANT 497
FT /note="P -> S (in dbSNP:rs1133378)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_034667"
FT VARIANT 500
FT /note="L -> P (in dbSNP:rs608144)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_034668"
FT CONFLICT 38
FT /note="T -> A (in Ref. 1; BAC04057)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 505 AA; 57331 MW; 39F780DF2B525E94 CRC64;
MATGALLPCS RPCPMSRLDF LKASHFSLGP DLRLHEGTMR TTSHRDFAYP AATREPPSLQ
PPPALLFPMD PRWDREERVS EAHRAFPPPS TPPWELLQAQ ARERTLAMQA GNLHLHEDAH
AGIGLSNAHA AYGWPELPAR TRERIRGARL IFDRDSLPPG DRDKLRIPPT THQALFPPHD
ARPQPRAPSC HLGGPNTLKW DYTRQDGTSY QRQFQALPGP PALRCKRASS GVELGDCKIS
YGSTCSEQKQ AYRPQDLPED RYDKAQATAH IHCVNIRPGD GLFRDRTTKA EHFYAREPEP
FVLHHDQTPE SHILKGNWCP GPGSLDTFMQ YFYGQPPPPT QPPSRHVPHE KLQSHVTLGE
PKLLKRFFKT TMGSDYCPSE WRQVQKAPNL HLQQSYLPRG TGEFDFLTMN QKMLKPHRTP
PAPVTEEMLQ RCKYSHMEPP LGGLRFFSTQ YKDEFPFKYQ GPAALRLKNP QEGFVPLGTP
HQRGCREKID PLVPQPPMYL CPSQQ
