ID   TEX46_HUMAN             Reviewed;         121 AA.
AC   H3BTG2; H3BR39;
DT   18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2012, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Testis-expressed protein 46;
DE   Flags: Precursor;
GN   Name=TEX46 {ECO:0000312|HGNC:HGNC:44651}; Synonyms=C1orf234;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Placenta;
RA   Li W.B., Gruber C., Jessee J., Polayes D.;
RT   "Full-length cDNA libraries and normalization.";
RL   Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=H3BTG2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=H3BTG2-2; Sequence=VSP_047833, VSP_047834;
CC   -!- TISSUE SPECIFICITY: Testis-specific. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BX377446; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; BX377446; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AL031428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL355534; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AI652913; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS57978.1; -. [H3BTG2-1]
DR   RefSeq; NP_001229450.1; NM_001242521.1. [H3BTG2-1]
DR   AlphaFoldDB; H3BTG2; -.
DR   SMR; H3BTG2; -.
DR   BioMuta; TEX46; -.
DR   MassIVE; H3BTG2; -.
DR   PeptideAtlas; H3BTG2; -.
DR   PRIDE; H3BTG2; -.
DR   DNASU; 729059; -.
DR   Ensembl; ENST00000566855.4; ENSP00000457161.1; ENSG00000227868.7. [H3BTG2-1]
DR   GeneID; 729059; -.
DR   KEGG; hsa:729059; -.
DR   MANE-Select; ENST00000566855.4; ENSP00000457161.1; NM_001242521.2; NP_001229450.1.
DR   UCSC; uc001bgh.1; human. [H3BTG2-1]
DR   CTD; 729059; -.
DR   DisGeNET; 729059; -.
DR   GeneCards; TEX46; -.
DR   HGNC; HGNC:44651; TEX46.
DR   HPA; ENSG00000227868; Tissue enriched (testis).
DR   neXtProt; NX_H3BTG2; -.
DR   OpenTargets; ENSG00000227868; -.
DR   VEuPathDB; HostDB:ENSG00000227868; -.
DR   eggNOG; ENOG502ST3S; Eukaryota.
DR   GeneTree; ENSGT00390000007769; -.
DR   OMA; IVWNKMN; -.
DR   OrthoDB; 1553813at2759; -.
DR   TreeFam; TF339051; -.
DR   PathwayCommons; H3BTG2; -.
DR   BioGRID-ORCS; 729059; 21 hits in 957 CRISPR screens.
DR   ChiTaRS; TEX46; human.
DR   GenomeRNAi; 729059; -.
DR   Pharos; H3BTG2; Tdark.
DR   PRO; PR:H3BTG2; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; H3BTG2; protein.
DR   Bgee; ENSG00000227868; Expressed in left testis and 109 other tissues.
DR   ExpressionAtlas; H3BTG2; baseline and differential.
DR   Genevisible; H3BTG2; HS.
DR   InterPro; IPR038788; TEX46-like.
DR   PANTHER; PTHR39412; PTHR39412; 2.
DR   Pfam; PF17671; DUF5531; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome; Signal.
FT   SIGNAL          1..38
FT                   /evidence="ECO:0000255"
FT   CHAIN           39..121
FT                   /note="Testis-expressed protein 46"
FT                   /id="PRO_0000423414"
FT   VAR_SEQ         1..20
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_047833"
FT   VAR_SEQ         54
FT                   /note="Q -> QQEEEKPKTSENDSKNSKAVNTKEVNRTHACFAL (in isoform
FT                   2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_047834"
SQ   SEQUENCE   121 AA;  14053 MW;  8693956F10C5DBD6 CRC64;
     MSLHGILASA GTIGAVAAWL MSYKPALFGF LFLLLLLSNW LVKYEHKLTL PEPQQDEILQ
     RLLFSEMKMK VLENQMFIIW NKMNHHGRSS RHRNFPMKKH RMRRHESICP TLSDCTSSSP
     S