ID   TEX50_HUMAN             Reviewed;         177 AA.
AC   A0A1B0GTY4;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2016, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Testis-expressed protein 50 {ECO:0000305};
DE   Flags: Precursor;
GN   Name=TEX50 {ECO:0000312|HGNC:HGNC:52382};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I
CC       membrane protein {ECO:0000255}.
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DR   EMBL; BX248409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS81405.1; -.
DR   RefSeq; NP_001182119.1; NM_001195190.2.
DR   AlphaFoldDB; A0A1B0GTY4; -.
DR   BioMuta; TEX50; -.
DR   MassIVE; A0A1B0GTY4; -.
DR   PeptideAtlas; A0A1B0GTY4; -.
DR   DNASU; 730159; -.
DR   Ensembl; ENST00000417563.3; ENSP00000489890.1; ENSG00000232113.3.
DR   GeneID; 730159; -.
DR   KEGG; hsa:730159; -.
DR   MANE-Select; ENST00000417563.3; ENSP00000489890.1; NM_001195190.3; NP_001182119.1.
DR   CTD; 730159; -.
DR   GeneCards; TEX50; -.
DR   HGNC; HGNC:52382; TEX50.
DR   HPA; ENSG00000232113; Tissue enriched (testis).
DR   neXtProt; NX_A0A1B0GTY4; -.
DR   VEuPathDB; HostDB:ENSG00000232113; -.
DR   GeneTree; ENSGT00520000059630; -.
DR   OMA; AKVGWEI; -.
DR   OrthoDB; 1484062at2759; -.
DR   BioGRID-ORCS; 730159; 8 hits in 142 CRISPR screens.
DR   GenomeRNAi; 730159; -.
DR   Pharos; A0A1B0GTY4; Tdark.
DR   PRO; PR:A0A1B0GTY4; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; A0A1B0GTY4; protein.
DR   Bgee; ENSG00000232113; Expressed in right testis and 10 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR038833; TEX50.
DR   PANTHER; PTHR39232; PTHR39232; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..177
FT                   /note="Testis-expressed protein 50"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5008408626"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          155..177
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   177 AA;  20847 MW;  D429B47A82E43048 CRC64;
     MSNQRLPLIF SLLFICFFGE SFCICDGTVW TKVGWEILPE EVHYWKVKGS PSHCLPYLLD
     KLCCDFANMD IFQGCLYLIY NLLQAVFFVL FVLSVHYLWK KWKKHQKKLK KQASLEKPGN
     DLESPLINNI DQTLHRVATT ASVIYKIWEH RSHHPSSKKI KHCKLKKKSK EEGARRY