TEX55_HUMAN
ID TEX55_HUMAN Reviewed; 536 AA.
AC Q96M34; A1L4B7;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Testis-specific expressed protein 55 {ECO:0000312|HGNC:HGNC:26553};
DE AltName: Full=Testis-specific conserved, cAMP-dependent type II PK-anchoring protein {ECO:0000303|PubMed:19821082};
GN Name=TEX55 {ECO:0000312|HGNC:HGNC:26553};
GN Synonyms=C3orf30, TSCPA {ECO:0000303|PubMed:19821082};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-447.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-447.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=19821082; DOI=10.1007/s11596-009-0502-9;
RA Yu Z., Wu B., Tang A., Chen J., Guo X., Qin J., Gui Y., Cai Z.;
RT "Expression profile of a novel germ cell-specific gene, TSCPA, in mice and
RT human.";
RL J. Huazhong Univ. Sci. Technol. Med. Sci. 29:535-539(2009).
CC -!- INTERACTION:
CC Q96M34; P42858: HTT; NbExp=3; IntAct=EBI-25961624, EBI-466029;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A6X8Z9}.
CC -!- TISSUE SPECIFICITY: Testis-specific. {ECO:0000269|PubMed:19821082}.
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DR EMBL; AK057421; BAB71478.1; -; mRNA.
DR EMBL; AC083800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW79578.1; -; Genomic_DNA.
DR EMBL; BC130475; AAI30476.1; -; mRNA.
DR CCDS; CCDS2984.1; -.
DR RefSeq; NP_689752.2; NM_152539.2.
DR AlphaFoldDB; Q96M34; -.
DR IntAct; Q96M34; 1.
DR STRING; 9606.ENSP00000295622; -.
DR iPTMnet; Q96M34; -.
DR PhosphoSitePlus; Q96M34; -.
DR BioMuta; C3orf30; -.
DR DMDM; 296434424; -.
DR MassIVE; Q96M34; -.
DR PaxDb; Q96M34; -.
DR PeptideAtlas; Q96M34; -.
DR PRIDE; Q96M34; -.
DR ProteomicsDB; 77291; -.
DR Antibodypedia; 68372; 31 antibodies from 10 providers.
DR DNASU; 152405; -.
DR Ensembl; ENST00000295622.6; ENSP00000295622.1; ENSG00000163424.9.
DR GeneID; 152405; -.
DR KEGG; hsa:152405; -.
DR MANE-Select; ENST00000295622.6; ENSP00000295622.1; NM_152539.3; NP_689752.2.
DR UCSC; uc003ecb.1; human.
DR CTD; 152405; -.
DR GeneCards; TEX55; -.
DR HGNC; HGNC:26553; TEX55.
DR HPA; ENSG00000163424; Tissue enriched (testis).
DR neXtProt; NX_Q96M34; -.
DR OpenTargets; ENSG00000163424; -.
DR PharmGKB; PA142672391; -.
DR VEuPathDB; HostDB:ENSG00000163424; -.
DR eggNOG; ENOG502QRWU; Eukaryota.
DR GeneTree; ENSGT00940000154487; -.
DR HOGENOM; CLU_034619_0_0_1; -.
DR InParanoid; Q96M34; -.
DR OMA; QTDHRLS; -.
DR OrthoDB; 979944at2759; -.
DR PhylomeDB; Q96M34; -.
DR TreeFam; TF328421; -.
DR PathwayCommons; Q96M34; -.
DR SignaLink; Q96M34; -.
DR BioGRID-ORCS; 152405; 4 hits in 1048 CRISPR screens.
DR GenomeRNAi; 152405; -.
DR Pharos; Q96M34; Tdark.
DR PRO; PR:Q96M34; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q96M34; protein.
DR Bgee; ENSG00000163424; Expressed in left testis and 22 other tissues.
DR ExpressionAtlas; Q96M34; baseline and differential.
DR Genevisible; Q96M34; HS.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR InterPro; IPR040760; DUF5582.
DR PANTHER; PTHR47110; PTHR47110; 3.
DR Pfam; PF17819; DUF5582; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..536
FT /note="Testis-specific expressed protein 55"
FT /id="PRO_0000254576"
FT REGION 1..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..51
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 45
FT /note="N -> T (in dbSNP:rs4687838)"
FT /id="VAR_028841"
FT VARIANT 99
FT /note="D -> G (in dbSNP:rs11550908)"
FT /id="VAR_028842"
FT VARIANT 193
FT /note="Q -> H (in dbSNP:rs9859242)"
FT /id="VAR_028843"
FT VARIANT 312
FT /note="G -> S (in dbSNP:rs4077930)"
FT /id="VAR_028844"
FT VARIANT 447
FT /note="S -> L (in dbSNP:rs56317615)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_061574"
FT VARIANT 473
FT /note="D -> E (in dbSNP:rs9289122)"
FT /id="VAR_028845"
SQ SEQUENCE 536 AA; 60162 MW; 6818EAC27D60D90C CRC64;
MEEPPQEALA EPLKHESPAA PSSAGHTKGQ EEDDQKNQAE RKADNHTAHR IADQTALRVP
SQAESSIFSQ ATNGVAEQNG HSTPGQAGRR ASNPADVSDL RADDQVNQTP SEQTKGKASS
QANNVQHEQS DGQVSGLTEE RTAEQTERRL PTQAERRTSG QIDGRLAMPS DQRGSRQTDH
RMAGQSERRA SEQMDRRMSG EAERRTSEQI THRLSKLSER RPSVQIDSGS SVPSDQSPSV
QIDSGSSVPS DQRPSVQIDR RMSGKVRRRS SEKTDYRLAG LADPGTSEQT DLRLYGLVDH
KTSVKTHHQV YGQATELAEH QAIDQAHSNA DQPPVDNAHY TESDQTDHLA DRQANHKDQL
SYYETRGQSE DRIFPQLGNS KEDKEADYRV QPCKFEDSQV DLNSKPSVEM ETQNATTIPP
YNPVDARFTS NFQAKDQALF PRLPSISSKL NYTSSQEKTQ AIVTKSDEFS EIDQGKGYHI
RNQTYRRFPS IVYEDPYQVS LQYMEKHHIL QIFQQITENL VYEKPEDPLN FMLCQV
