ID   TEX9_HUMAN              Reviewed;         391 AA.
AC   Q8N6V9; B4DH73;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Testis-expressed protein 9;
GN   Name=TEX9;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA   Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA   Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q8N6V9; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-746341, EBI-10175300;
CC       Q8N6V9; Q08379: GOLGA2; NbExp=3; IntAct=EBI-746341, EBI-618309;
CC       Q8N6V9; Q7RTV2: GSTA5; NbExp=3; IntAct=EBI-746341, EBI-13328621;
CC       Q8N6V9; O60341: KDM1A; NbExp=4; IntAct=EBI-746341, EBI-710124;
CC       Q8N6V9; O94818-2: NOL4; NbExp=6; IntAct=EBI-746341, EBI-10190763;
CC       Q8N6V9; Q9UBU9: NXF1; NbExp=3; IntAct=EBI-746341, EBI-398874;
CC       Q8N6V9; Q96KQ4: PPP1R13B; NbExp=3; IntAct=EBI-746341, EBI-1105153;
CC       Q8N6V9; O14530: TXNDC9; NbExp=3; IntAct=EBI-746341, EBI-707554;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8N6V9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N6V9-2; Sequence=VSP_055381;
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DR   EMBL; AK294960; BAG58034.1; -; mRNA.
DR   EMBL; AC068726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC084782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471082; EAW77500.1; -; Genomic_DNA.
DR   EMBL; BC028119; AAH28119.1; -; mRNA.
DR   CCDS; CCDS10157.1; -. [Q8N6V9-1]
DR   CCDS; CCDS66776.1; -. [Q8N6V9-2]
DR   RefSeq; NP_001273378.1; NM_001286449.1. [Q8N6V9-2]
DR   RefSeq; NP_940926.1; NM_198524.2. [Q8N6V9-1]
DR   RefSeq; XP_005254416.1; XM_005254359.4. [Q8N6V9-1]
DR   RefSeq; XP_005254418.1; XM_005254361.3. [Q8N6V9-2]
DR   RefSeq; XP_011519832.1; XM_011521530.2. [Q8N6V9-1]
DR   RefSeq; XP_016877649.1; XM_017022160.1. [Q8N6V9-1]
DR   RefSeq; XP_016877652.1; XM_017022163.1. [Q8N6V9-2]
DR   RefSeq; XP_016877653.1; XM_017022164.1. [Q8N6V9-2]
DR   AlphaFoldDB; Q8N6V9; -.
DR   SMR; Q8N6V9; -.
DR   BioGRID; 131910; 36.
DR   IntAct; Q8N6V9; 16.
DR   MINT; Q8N6V9; -.
DR   STRING; 9606.ENSP00000342169; -.
DR   iPTMnet; Q8N6V9; -.
DR   PhosphoSitePlus; Q8N6V9; -.
DR   BioMuta; TEX9; -.
DR   DMDM; 74729187; -.
DR   EPD; Q8N6V9; -.
DR   MassIVE; Q8N6V9; -.
DR   PaxDb; Q8N6V9; -.
DR   PeptideAtlas; Q8N6V9; -.
DR   PRIDE; Q8N6V9; -.
DR   ProteomicsDB; 4201; -.
DR   ProteomicsDB; 72242; -. [Q8N6V9-1]
DR   Antibodypedia; 42704; 89 antibodies from 19 providers.
DR   DNASU; 374618; -.
DR   Ensembl; ENST00000352903.6; ENSP00000342169.2; ENSG00000151575.14. [Q8N6V9-1]
DR   Ensembl; ENST00000537232.5; ENSP00000438745.1; ENSG00000151575.14. [Q8N6V9-2]
DR   GeneID; 374618; -.
DR   KEGG; hsa:374618; -.
DR   UCSC; uc002adp.5; human. [Q8N6V9-1]
DR   CTD; 374618; -.
DR   DisGeNET; 374618; -.
DR   GeneCards; TEX9; -.
DR   HGNC; HGNC:29585; TEX9.
DR   HPA; ENSG00000151575; Low tissue specificity.
DR   MalaCards; TEX9; -.
DR   neXtProt; NX_Q8N6V9; -.
DR   OpenTargets; ENSG00000151575; -.
DR   PharmGKB; PA142670821; -.
DR   VEuPathDB; HostDB:ENSG00000151575; -.
DR   eggNOG; ENOG502QPKV; Eukaryota.
DR   GeneTree; ENSGT00390000018333; -.
DR   HOGENOM; CLU_059201_0_0_1; -.
DR   InParanoid; Q8N6V9; -.
DR   OMA; SKQMKSC; -.
DR   PhylomeDB; Q8N6V9; -.
DR   TreeFam; TF327209; -.
DR   PathwayCommons; Q8N6V9; -.
DR   SignaLink; Q8N6V9; -.
DR   BioGRID-ORCS; 374618; 16 hits in 1076 CRISPR screens.
DR   ChiTaRS; TEX9; human.
DR   GenomeRNAi; 374618; -.
DR   Pharos; Q8N6V9; Tdark.
DR   PRO; PR:Q8N6V9; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; Q8N6V9; protein.
DR   Bgee; ENSG00000151575; Expressed in calcaneal tendon and 123 other tissues.
DR   ExpressionAtlas; Q8N6V9; baseline and differential.
DR   Genevisible; Q8N6V9; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Reference proteome.
FT   CHAIN           1..391
FT                   /note="Testis-expressed protein 9"
FT                   /id="PRO_0000244481"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          65..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          188..351
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..75
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_055381"
SQ   SEQUENCE   391 AA;  44826 MW;  233589EFF410BBA8 CRC64;
     MAGRSLCLTR SSVPGTPFPP PVQQPSTPGP DLLALEEEYK RLNAELQAKT ADVVQQAKEI
     IRDRQEVRSR PVSTQMKSCD DEDDYSLRGL LPSEGIVHLH SETKPKTKNI DPVNKVQNKL
     HSANKGRKTN SSVKLKYSDV QTADDVAIPE DFSDFSLAKT ISKIEGQLEE EGLPEYIDDI
     FSGVSNDIGT EAQIRFLKAK LHVMQEELDN VVCECNKKED EIQNLKSQVK NFEEDFMRQQ
     RTINMQQSQV EKYKTLFEEA NKKYDGLQQQ LSSVERELEN KRRLQKQAAS SQSATEVRLN
     RALEEAEKYK LELSKLRQNN KDIANEEHKK IEVLKSENKK LEKQKGELMI GFKKQLKLID
     VLKRQKMHIE AAKMLSFTEE EFMKALEWGN S