TEY_DROME
ID TEY_DROME Reviewed; 717 AA.
AC Q9VW27;
DT 08-JUN-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Protein Teyrha-meyrha {ECO:0000312|FlyBase:FBgn0036899};
GN Name=tey {ECO:0000312|FlyBase:FBgn0036899};
GN ORFNames=CG8780 {ECO:0000312|FlyBase:FBgn0036899};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AFH89829.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=17028348; DOI=10.1534/genetics.106.056788;
RA Jacobsen T.L., Cain D., Paul L., Justiniano S., Alli A., Mullins J.S.,
RA Wang C.P., Butchar J.P., Simcox A.;
RT "Functional analysis of genes differentially expressed in the Drosophila
RT wing disc: role of transcripts enriched in the wing region.";
RL Genetics 174:1973-1982(2006).
RN [5] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=20504957; DOI=10.1242/dev.046672;
RA Inaki M., Shinza-Kameda M., Ismat A., Frasch M., Nose A.;
RT "Drosophila Tey represses transcription of the repulsive cue Toll and
RT generates neuromuscular target specificity.";
RL Development 137:2139-2146(2010).
CC -!- FUNCTION: Required for the correct synaptic targeting of motoneurons
CC RP5 and V to muscle 12 (M12) (PubMed:20504957). May be involved in the
CC negative regulation of Tl in M12 (PubMed:20504957). Involved in the
CC correct patterning of veins in the proximal (costal) region of the wing
CC blade (PubMed:17028348). {ECO:0000269|PubMed:17028348,
CC ECO:0000269|PubMed:20504957}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20504957}.
CC -!- TISSUE SPECIFICITY: In embryos, expressed specifically in M12 (at
CC protein level). {ECO:0000269|PubMed:20504957}.
CC -!- DISRUPTION PHENOTYPE: In embryos, M12 position is closer to the ventral
CC nerve cord and situated ventral to muscle 13 (M13) and external to
CC muscle 6/7 (PubMed:20504957). The longitudinal orientation of M12 is
CC also oblique probably due to an alteration in the muscle attachment
CC sites (PubMed:20504957). Also displays a reduced number of synaptic
CC sites on M12. No effect on muscle fiber size (PubMed:20504957). RNAi-
CC mediated knockdown results in the fusion of the costal vein with the L1
CC vein in the developing wing, producing an adult wing that has a
CC continuous wing margin with no separation between the end of the costal
CC and L1 veins (PubMed:17028348). The medial and distal regions of the
CC costal vein are also fused (PubMed:17028348). Thickening of the costal
CC vein often occurs, and sometimes spans the region between the costal
CC and subcostal veins (PubMed:17028348). {ECO:0000269|PubMed:17028348,
CC ECO:0000269|PubMed:20504957}.
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DR EMBL; AE014296; AAF49126.2; -; Genomic_DNA.
DR EMBL; BT133456; AFH89829.1; -; mRNA.
DR RefSeq; NP_649140.1; NM_140883.2.
DR AlphaFoldDB; Q9VW27; -.
DR IntAct; Q9VW27; 2.
DR STRING; 7227.FBpp0271915; -.
DR EnsemblMetazoa; FBtr0074960; FBpp0074728; FBgn0036899.
DR GeneID; 40146; -.
DR KEGG; dme:Dmel_CG8780; -.
DR UCSC; CG8780-RA; d. melanogaster.
DR CTD; 40146; -.
DR FlyBase; FBgn0036899; tey.
DR VEuPathDB; VectorBase:FBgn0036899; -.
DR eggNOG; ENOG502QR1N; Eukaryota.
DR GeneTree; ENSGT00390000016573; -.
DR HOGENOM; CLU_362599_0_0_1; -.
DR BioGRID-ORCS; 40146; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 40146; -.
DR PRO; PR:Q9VW27; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0036899; Expressed in second segment of antenna (Drosophila) and 19 other tissues.
DR ExpressionAtlas; Q9VW27; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:FlyBase.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0008039; P:synaptic target recognition; IMP:FlyBase.
DR InterPro; IPR031824; RNF220_mid.
DR Pfam; PF15926; RNF220; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..717
FT /note="Protein Teyrha-meyrha"
FT /id="PRO_0000436309"
FT REGION 140..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..263
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..455
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 649..717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 717 AA; 76716 MW; 887D6033BD9FF679 CRC64;
MESNAFGSSH LPSQALVVLS EAASGLHEAL RGQRPFPSRV IPFDFPLLQL PDAKDLHNMS
LVGNYFNPHL LLNHGMLVAN GAAAAAAAAG AGPASYFASD RSPLGKPSVL SNFSLPSAFS
PPKYIGISLD QNLFNGSESF RTDSASPTCT SHESMEGSQD YDAVEKGESP RSNNSQDPRD
LRHLHNAGKS HQALATSSSA SSSSSSSCST SNPAISTATS SVAVSMASHL AASSPHHHPH
THAHSHPHPL AHPHAHSHHH VGHHVGAPPV STAVTTHHHM AHPHPLSHHH AAHHAALASL
SMAGLRAVPG GLSLVSGLQA AAAGGAIPEM CPVCGLKLSA EEWHTHFLTE LDRLYKLSAG
FERASLQATY MFAPPCPAQE NAIRTSHNRW ETFQRIRNNR QNRLRLKVRK RKYGEMYMME
SLYCSSCPIC KRKYALETGK IPPEDDAKSQ EEIETVDVES CNDEVPDSGS ELATPSSGSS
GTVMPPSSMH NSNSQPGKLD GILYRTGCVL SQKDPHPDEH DVSTNVTTAS SSSWPGEAPT
QAHISVKTVS ELSSTTHHYY NADSCGVGVN DTNSSSSTHN NGGGSNKDLM MDTASCQNDS
DEDVIVDDDD TVKLTSKINY GKIQRRQDEQ NVGSSRSLEN ISPVEERPRS EPQVSSTEPG
PMDISHNNNN NNNNNNNNSN SNNNNNPSTK YAESMENSLS QLSSMGVPGL TQLDTKA
