ID   TF177_GIBF5             Reviewed;         742 AA.
AC   S0EJF2;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2013, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Transcription factor FFUJ_09177 {ECO:0000303|PubMed:28295904};
DE   AltName: Full=DMATS1 biosynthesis cluster protein FFUJ_09177 {ECO:0000303|PubMed:28295904};
GN   ORFNames=FFUJ_09177;
OS   Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae
OS   and foot rot disease fungus) (Fusarium fujikuroi).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium fujikuroi species complex.
OX   NCBI_TaxID=1279085;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 195.34 / IMI 58289 / NRRL A-6831;
RX   PubMed=23825955; DOI=10.1371/journal.ppat.1003475;
RA   Wiemann P., Sieber C.M.K., von Bargen K.W., Studt L., Niehaus E.-M.,
RA   Espino J.J., Huss K., Michielse C.B., Albermann S., Wagner D.,
RA   Bergner S.V., Connolly L.R., Fischer A., Reuter G., Kleigrewe K., Bald T.,
RA   Wingfield B.D., Ophir R., Freeman S., Hippler M., Smith K.M., Brown D.W.,
RA   Proctor R.H., Muensterkoetter M., Freitag M., Humpf H.-U., Gueldener U.,
RA   Tudzynski B.;
RT   "Deciphering the cryptic genome: genome-wide analyses of the rice pathogen
RT   Fusarium fujikuroi reveal complex regulation of secondary metabolism and
RT   novel metabolites.";
RL   PLoS Pathog. 9:E1003475-E1003475(2013).
RN   [2]
RP   FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=28295904; DOI=10.1002/cbic.201600691;
RA   Arndt B., Janevska S., Schmid R., Huebner F., Tudzynski B., Humpf H.U.;
RT   "A Fungal N-Dimethylallyltryptophan Metabolite from Fusarium fujikuroi.";
RL   ChemBioChem 18:899-904(2017).
CC   -!- FUNCTION: Transcription factor; part of the DMATS1 gene cluster that
CC       mediates the biosynthesis of a reversely N-prenylated monomeric L-
CC       tryptophan (r-N-DMAT) (PubMed:28295904). Seems not to regulate the
CC       expression of the DMATS1 cluster (PubMed:28295904).
CC       {ECO:0000269|PubMed:28295904}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- INDUCTION: Expression is negaticely regulated by the global nitrogen
CC       regulator areA. {ECO:0000269|PubMed:28295904}.
CC   -!- DISRUPTION PHENOTYPE: Does not affect the expression of expression of
CC       DMATS1, FFUJ_09176,and FFUJ_09178; nor the metabolite production.
CC       {ECO:0000269|PubMed:28295904}.
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DR   EMBL; HF679031; CCT73987.1; -; Genomic_DNA.
DR   AlphaFoldDB; S0EJF2; -.
DR   SMR; S0EJF2; -.
DR   STRING; 5127.CCT73987; -.
DR   EnsemblFungi; CCT73987; CCT73987; FFUJ_09177.
DR   VEuPathDB; FungiDB:FFUJ_09177; -.
DR   HOGENOM; CLU_003864_3_0_1; -.
DR   Proteomes; UP000016800; Chromosome 9.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..742
FT                   /note="Transcription factor FFUJ_09177"
FT                   /id="PRO_0000452657"
FT   DNA_BIND        15..41
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          50..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        218..239
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   742 AA;  83525 MW;  38DD1717FF5DC438 CRC64;
     MTRRSRRVAY VAKACVSCAR SKQRCDGHSP CGRCSLKNLD CVYRHLLQKG QNSTRGASPQ
     SPSASRESYS QNTLPVVQSQ TRPLALDSAP SVYSPASEAI GEPPSLSTDV GNNFVEMSMD
     SGQETFPDGV SVNNLTFKIG ESDLQGWASL GVDIPWNSSM HSMLDNPLFE LPDPMAFFFQ
     SPSELLGQSD VQAIPCPMDS EPMVHQLECE TPTPNFTHSL DISSYQGQSN QTSPETTSHS
     SVRDDAELES WRAEDYGHVP DINDEAYQVM VFTFEQLNSD NVYCIPFTDK HLPSLQHMQI
     YMQVYFEEYH PIFPLLHKAT FSPNKDDWLL SLAVSSIGCL FSKTLRSKEV FPIMQEFLRR
     AIRIQTSTPS ISVAQASVLN QIGMMYGGDL RFAECAHETM AQLTTQCRKI ASSSHNLANS
     SIAENTVSQG WQAWVRAQLE IRLFYCAWLV DSQQVGFFAF SSTIPIDFLQ FPMPINEYVW
     GMSTAETWQN SLAEDSSSQQ LTSLRQVLMG LYRYREVPGQ LDAFNSLLLV MGILNDLSGL
     RHAHLYLEIL QRRVETLPPT ALTRAVMTNI HMVSLLIYFP TREVIAFGRW RVTEAQHSIV
     TEKLKRWMSD TRSARAALVH ACSIWSQVRL SRTNSHHEPP ALLYSAISIW ALVEHSEEVV
     ENADELPILR LDSLNQDVKL WAAGNEKKRL YLSGVGLLAH RGALARLISE TARLLEQRIA
     WPQAWRTGPH LKQSYAESRR VQ