TF29_ZYMTI
ID TF29_ZYMTI Reviewed; 978 AA.
AC F9XMW5;
DT 07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 1.
DT 25-MAY-2022, entry version 54.
DE RecName: Full=Transcription factor MYCGRDRAFT_87993 {ECO:0000303|PubMed:28818040};
DE AltName: Full=Conidial pigment biosynthesis cluster 29 protein MYCGRDRAFT_87993 {ECO:0000303|PubMed:28818040};
GN ORFNames=MYCGRDRAFT_87993;
OS Zymoseptoria tritici (strain CBS 115943 / IPO323) (Speckled leaf blotch
OS fungus) (Septoria tritici).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Zymoseptoria.
OX NCBI_TaxID=336722;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 115943 / IPO323;
RX PubMed=21695235; DOI=10.1371/journal.pgen.1002070;
RA Goodwin S.B., Ben M'barek S., Dhillon B., Wittenberg A.H.J., Crane C.F.,
RA Hane J.K., Foster A.J., Van der Lee T.A.J., Grimwood J., Aerts A.,
RA Antoniw J., Bailey A., Bluhm B., Bowler J., Bristow J., van der Burgt A.,
RA Canto-Canche B., Churchill A.C.L., Conde-Ferraez L., Cools H.J.,
RA Coutinho P.M., Csukai M., Dehal P., De Wit P., Donzelli B.,
RA van de Geest H.C., van Ham R.C.H.J., Hammond-Kosack K.E., Henrissat B.,
RA Kilian A., Kobayashi A.K., Koopmann E., Kourmpetis Y., Kuzniar A.,
RA Lindquist E., Lombard V., Maliepaard C., Martins N., Mehrabi R.,
RA Nap J.P.H., Ponomarenko A., Rudd J.J., Salamov A., Schmutz J.,
RA Schouten H.J., Shapiro H., Stergiopoulos I., Torriani S.F.F., Tu H.,
RA de Vries R.P., Waalwijk C., Ware S.B., Wiebenga A., Zwiers L.-H.,
RA Oliver R.P., Grigoriev I.V., Kema G.H.J.;
RT "Finished genome of the fungal wheat pathogen Mycosphaerella graminicola
RT reveals dispensome structure, chromosome plasticity, and stealth
RT pathogenesis.";
RL PLoS Genet. 7:E1002070-E1002070(2011).
RN [2]
RP FUNCTION, AND PATHWAY.
RX PubMed=28818040; DOI=10.1186/s12864-017-3969-y;
RA Cairns T., Meyer V.;
RT "In silico prediction and characterization of secondary metabolite
RT biosynthetic gene clusters in the wheat pathogen Zymoseptoria tritici.";
RL BMC Genomics 18:631-631(2017).
CC -!- FUNCTION: Transcription factor; part of the gene cluster 29 that
CC mediates the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a
CC bluish-green pigment forming a dark layer in the conidial wall that
CC protects the conidia from UV radiations. {ECO:0000305|PubMed:28818040}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR EMBL; CM001206; EGP83310.1; -; Genomic_DNA.
DR RefSeq; XP_003848334.1; XM_003848286.1.
DR AlphaFoldDB; F9XMW5; -.
DR STRING; 1047171.Mycgr3P87993; -.
DR EnsemblFungi; Mycgr3T87993; Mycgr3P87993; Mycgr3G87993.
DR GeneID; 13396130; -.
DR KEGG; ztr:MYCGRDRAFT_87993; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_008362_0_0_1; -.
DR InParanoid; F9XMW5; -.
DR Proteomes; UP000008062; Chromosome 11.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 2.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..978
FT /note="Transcription factor MYCGRDRAFT_87993"
FT /id="PRO_0000451092"
FT ZN_FING 2..24
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 30..52
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT DNA_BIND 79..105
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 113..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 978 AA; 109089 MW; 5191EF8A337EE39B CRC64;
MVFCTYCGQS FTRDEHLERH ILTHTNVKPF KCFTCHMSFA RRDLLQRHYT VHGRDQNQNE
IPAVNGMIPK SAGRTPIACS NCAKTKTKCD KKFPCSRCAG RNLRCTLRPT RRASKNANRV
GATLESATDV PTEVTTVNVE ATSKDTRAQE NSSSPSSQKS GTPISIGPIM EETPDIAPPQ
PFTEQVNGGP TPPEFSPDLQ ESFMDHNLMS GFPGLTNPSK DSSDDGSSPR FLLDWSQMQM
PLGYDNMIQS DLMLDPELSF DPNSVPLAPH ADGILSIMPE LANGGMESLI TPFETPKMSR
SFVELGLGNS NPAFHSHRHQ SMPSVQSIPN SGNEMPAMIA AQDGWSAFRC TPTLPSSSCP
KTAKLNLEQL EETLRNHEGW VSWSPRWEDN DLAGGGDHLT VMQLHESTRD KLLAIMQSFL
HKALETHREG RGTSNGSHSP NPSGASNFVL LPPGRVLEYF LRSYSNSFER YFPLTSRSTL
DANELMHCYN DRAASILVLL MIAQGAANIP SPEARMLTGG LTEACRISLF DLIERNIIMS
GDPIVLHSAL LFTVQAAWSG DKWQMDIAMG QRGMYFAMLR HSGVLDRSSH AASAQPQRTL
EQLWTDWIQN ESRSRLIYSW VMVDQDLALF HDTAPLFSVT EFGAPMPDAD RLWHAKSAEQ
WSSTFERVHE FSSGFSSVGS GARPLSLRDL FRHFLDDDLI PMGIEMTPLQ LRLLLHPLQS
MVCQFSQLLS CFAPATYRTS ISVHPNQAQP SSRNISQSST RTRLAEVQAL LQRWFDLAER
YLKANPLCAL MQTNLILFHL ISLNAVTNFP EIERLARREN VDGTYHQLLW LHKRCIPDVE
EAVFHCGQIF RLVRSMPRGV RPPWWAGAIY RVALILWTDS LTHKDALTST SPQGNGMFPS
PIAGPSFAID ALPPDHALIV RYLTKREGVP CVTKLDGSQM GLERAYPVLR HCVEVIDEGC
STRFSDAIRG KLERLSRG
