ID   TF2AA_DICDI             Reviewed;         310 AA.
AC   Q54G80;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Transcription initiation factor IIA subunit 1;
DE   AltName: Full=General transcription factor IIA subunit 1;
GN   Name=gtf2a1; Synonyms=tfiial; ORFNames=DDB_G0290327;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: TFIIA is a component of the transcription machinery of RNA
CC       polymerase II and plays an important role in transcriptional
CC       activation. TFIIA in a complex with tbp mediates transcriptional
CC       activity (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: TFIIA is a heterodimer of the large subunit 1 and a small
CC       subunit gamma. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TFIIA subunit 1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000162; EAL62290.1; -; Genomic_DNA.
DR   RefSeq; XP_635803.1; XM_630711.1.
DR   AlphaFoldDB; Q54G80; -.
DR   SMR; Q54G80; -.
DR   STRING; 44689.DDB0216284; -.
DR   PaxDb; Q54G80; -.
DR   EnsemblProtists; EAL62290; EAL62290; DDB_G0290327.
DR   GeneID; 8627608; -.
DR   KEGG; ddi:DDB_G0290327; -.
DR   dictyBase; DDB_G0290327; gtf2a1.
DR   eggNOG; KOG2652; Eukaryota.
DR   HOGENOM; CLU_030027_0_0_1; -.
DR   InParanoid; Q54G80; -.
DR   OMA; VLCQYEK; -.
DR   Reactome; R-DDI-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-DDI-6807505; RNA polymerase II transcribes snRNA genes.
DR   Reactome; R-DDI-73776; RNA Polymerase II Promoter Escape.
DR   Reactome; R-DDI-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR   Reactome; R-DDI-75953; RNA Polymerase II Transcription Initiation.
DR   Reactome; R-DDI-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR   PRO; PR:Q54G80; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005672; C:transcription factor TFIIA complex; ISS:dictyBase.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; ISS:dictyBase.
DR   Gene3D; 2.30.18.10; -; 1.
DR   InterPro; IPR004855; TFIIA_asu/bsu.
DR   InterPro; IPR009088; TFIIA_b-brl.
DR   PANTHER; PTHR12694; PTHR12694; 2.
DR   Pfam; PF03153; TFIIA; 1.
DR   SMART; SM01371; TFIIA; 1.
DR   SUPFAM; SSF50784; SSF50784; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..310
FT                   /note="Transcription initiation factor IIA subunit 1"
FT                   /id="PRO_0000328131"
FT   REGION          52..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          91..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..173
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   310 AA;  34518 MW;  E9E5D5FD35B69203 CRC64;
     MSVDSVYKYI VFDVIRNIKS NIKNDSDTEN VDESIIDEIQ TMWLDRLTQT GAISNQNDPD
     ETTATTTTTQ PQSTLSTVEH ENVRNTLNSL IQLNNKSQTT TTTTTSTFGN PQQYLPPQKE
     VSNGTSPTMN SSNGSNNNNN NNNSNNSSNS SNNNNLPSSL RSIMNPMPQN DGTLDESDND
     DDNNNNNNDN DNENNKDNID KLIIDGFKKN FNFNGDEVIP QNDGLNDDDD LDDEEIGGGG
     GKVEEDSLGS DLDDDDDDDP DPIIEHFVLC QYEKVSRIKN KRKCNFKDGI MHLNGKDTLF
     NKANGEMIWN