ID   TF2B1_HALSA             Reviewed;         287 AA.
AC   Q9HNA2;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Transcription initiation factor IIB 1 {ECO:0000255|HAMAP-Rule:MF_00383};
DE            Short=TFIIB 1 {ECO:0000255|HAMAP-Rule:MF_00383};
GN   Name=tfbA {ECO:0000255|HAMAP-Rule:MF_00383}; OrderedLocusNames=VNG_2184G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- FUNCTION: Stabilizes TBP binding to an archaeal box-A promoter. Also
CC       responsible for recruiting RNA polymerase II to the pre-initiation
CC       complex (DNA-TBP-TFIIB). {ECO:0000255|HAMAP-Rule:MF_00383}.
CC   -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00383}.
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DR   EMBL; AE004437; AAG20319.1; -; Genomic_DNA.
DR   PIR; C84369; C84369.
DR   RefSeq; WP_010903620.1; NC_002607.1.
DR   AlphaFoldDB; Q9HNA2; -.
DR   SMR; Q9HNA2; -.
DR   STRING; 64091.VNG_2184G; -.
DR   PaxDb; Q9HNA2; -.
DR   EnsemblBacteria; AAG20319; AAG20319; VNG_2184G.
DR   GeneID; 5953282; -.
DR   KEGG; hal:VNG_2184G; -.
DR   PATRIC; fig|64091.14.peg.1678; -.
DR   HOGENOM; CLU_043736_0_0_2; -.
DR   InParanoid; Q9HNA2; -.
DR   OMA; RERNQVY; -.
DR   OrthoDB; 35979at2157; -.
DR   PhylomeDB; Q9HNA2; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0097550; C:transcription preinitiation complex; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR   GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 2.
DR   HAMAP; MF_00383; TF2B_arch; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR000812; TFIIB.
DR   InterPro; IPR023484; TFIIB_arc.
DR   InterPro; IPR013150; TFIIB_cyclin.
DR   InterPro; IPR013137; Znf_TFIIB.
DR   PANTHER; PTHR11618; PTHR11618; 1.
DR   Pfam; PF08271; TF_Zn_Ribbon; 1.
DR   Pfam; PF00382; TFIIB; 2.
DR   PRINTS; PR00685; TIFACTORIIB.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS51134; ZF_TFIIB; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..287
FT                   /note="Transcription initiation factor IIB 1"
FT                   /id="PRO_0000119311"
FT   REPEAT          111..194
FT                   /note="1"
FT   REPEAT          205..286
FT                   /note="2"
FT   ZN_FING         3..31
FT                   /note="TFIIB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   REGION          40..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         7
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         10
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         23
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         26
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
SQ   SEQUENCE   287 AA;  31113 MW;  15B8C353E80F7643 CRC64;
     MQHPHRCPEC DGTIRETDTE HVCADCGLVV TDAPIDHGPE WRTFSDDPDH APERTGAPLT
     RSRHDRGLST EIGYSARLTG RKRRKFARLR RQHKRATIPS KADYNRIYGF TEIRRLIGTF
     GIGTGLRDQA CTLFASAQTA GLLHGRTIEG FAAAGVYATC RTNGVTRTLD EIAAAARATR
     PELTTAYDAM NRDLGLPTGP IDPREYLPRY ADALSLPARI ERQARELVAA LETDGLVAGR
     NPSGVAAGCL YTAATETDHA VTQSAAAAVA DVTPVTLRAT YQNLTDA