TF2B1_SACS2
ID TF2B1_SACS2 Reviewed; 309 AA.
AC P58111;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Transcription initiation factor IIB 1 {ECO:0000255|HAMAP-Rule:MF_00383};
DE Short=TFIIB 1 {ECO:0000255|HAMAP-Rule:MF_00383};
GN Name=tfbA {ECO:0000255|HAMAP-Rule:MF_00383}; Synonyms=tfb-1;
GN OrderedLocusNames=SSO0446; ORFNames=C43_009;
OS Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS (Sulfolobus solfataricus).
OC Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Saccharolobus.
OX NCBI_TaxID=273057;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX PubMed=11427726; DOI=10.1073/pnas.141222098;
RA She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
CC -!- FUNCTION: Stabilizes TBP binding to an archaeal box-A promoter. Also
CC responsible for recruiting RNA polymerase II to the pre-initiation
CC complex (DNA-TBP-TFIIB). {ECO:0000255|HAMAP-Rule:MF_00383}.
CC -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000255|HAMAP-
CC Rule:MF_00383}.
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DR EMBL; AE006641; AAK40772.1; -; Genomic_DNA.
DR PIR; E90189; E90189.
DR AlphaFoldDB; P58111; -.
DR SMR; P58111; -.
DR STRING; 273057.SSO0446; -.
DR EnsemblBacteria; AAK40772; AAK40772; SSO0446.
DR KEGG; sso:SSO0446; -.
DR PATRIC; fig|273057.12.peg.440; -.
DR eggNOG; arCOG01981; Archaea.
DR HOGENOM; CLU_043736_0_1_2; -.
DR InParanoid; P58111; -.
DR OMA; RTQKDFA; -.
DR PhylomeDB; P58111; -.
DR Proteomes; UP000001974; Chromosome.
DR GO; GO:0097550; C:transcription preinitiation complex; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro.
DR CDD; cd00043; CYCLIN; 2.
DR HAMAP; MF_00383; TF2B_arch; 1.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR000812; TFIIB.
DR InterPro; IPR023484; TFIIB_arc.
DR InterPro; IPR023486; TFIIB_CS.
DR InterPro; IPR013150; TFIIB_cyclin.
DR InterPro; IPR013137; Znf_TFIIB.
DR PANTHER; PTHR11618; PTHR11618; 1.
DR Pfam; PF08271; TF_Zn_Ribbon; 1.
DR Pfam; PF00382; TFIIB; 2.
DR PRINTS; PR00685; TIFACTORIIB.
DR SMART; SM00385; CYCLIN; 2.
DR SUPFAM; SSF47954; SSF47954; 2.
DR PROSITE; PS00782; TFIIB; 2.
PE 3: Inferred from homology;
KW Reference proteome; Repeat; Transcription; Transcription regulation.
FT CHAIN 1..309
FT /note="Transcription initiation factor IIB 1"
FT /id="PRO_0000119335"
FT REPEAT 125..208
FT /note="1"
FT REPEAT 219..300
FT /note="2"
SQ SEQUENCE 309 AA; 34671 MW; 2AE719C83B93C0DF CRC64;
MLYLSEENKS VSTPCPPDKI IFDAERGEYI CSETGEVLED KIIDQGPEWR AFTPEEKEKR
SRVGGPLNNT IHDRGLSTLI DWKDKDAMGR TLDPKRRLEA LRWRKWQIRA RIQSSIDRNL
AQAMNELERI GNLLNLPKSV KDEAALIYRK AVEKGLVRGR SIESVVAAAI YAACRRMKLA
RTLDEIAQYT KANRKEVARC YRLLLRELDV SVPVSDPKDY VTRIANLLGL SGAVMKTAAE
IIDKAKGSGL TAGKDPAGLA AAAIYIASLL HDERRTQKEI AQVAGVTEVT VRNRYKELTQ
ELKISIPTQ
