ID   TF2B1_THEKO             Reviewed;         300 AA.
AC   Q5JGN1;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Transcription initiation factor IIB 1 {ECO:0000255|HAMAP-Rule:MF_00383};
DE            Short=TFIIB 1 {ECO:0000255|HAMAP-Rule:MF_00383};
GN   Name=tfb1 {ECO:0000255|HAMAP-Rule:MF_00383}; OrderedLocusNames=TK1280;
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT   kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL   Genome Res. 15:352-363(2005).
CC   -!- FUNCTION: Stabilizes TBP binding to an archaeal box-A promoter. Also
CC       responsible for recruiting RNA polymerase II to the pre-initiation
CC       complex (DNA-TBP-TFIIB). {ECO:0000255|HAMAP-Rule:MF_00383}.
CC   -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00383}.
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DR   EMBL; AP006878; BAD85469.1; -; Genomic_DNA.
DR   RefSeq; WP_011250231.1; NC_006624.1.
DR   AlphaFoldDB; Q5JGN1; -.
DR   SMR; Q5JGN1; -.
DR   STRING; 69014.TK1280; -.
DR   PRIDE; Q5JGN1; -.
DR   EnsemblBacteria; BAD85469; BAD85469; TK1280.
DR   GeneID; 3235472; -.
DR   KEGG; tko:TK1280; -.
DR   PATRIC; fig|69014.16.peg.1252; -.
DR   eggNOG; arCOG01981; Archaea.
DR   HOGENOM; CLU_043736_0_1_2; -.
DR   InParanoid; Q5JGN1; -.
DR   OMA; RTQKDFA; -.
DR   OrthoDB; 35979at2157; -.
DR   PhylomeDB; Q5JGN1; -.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0097550; C:transcription preinitiation complex; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR   GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 2.
DR   HAMAP; MF_00383; TF2B_arch; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR000812; TFIIB.
DR   InterPro; IPR023484; TFIIB_arc.
DR   InterPro; IPR023486; TFIIB_CS.
DR   InterPro; IPR013150; TFIIB_cyclin.
DR   InterPro; IPR013137; Znf_TFIIB.
DR   PANTHER; PTHR11618; PTHR11618; 1.
DR   Pfam; PF08271; TF_Zn_Ribbon; 1.
DR   Pfam; PF00382; TFIIB; 2.
DR   PRINTS; PR00685; TIFACTORIIB.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00782; TFIIB; 2.
DR   PROSITE; PS51134; ZF_TFIIB; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..300
FT                   /note="Transcription initiation factor IIB 1"
FT                   /id="PRO_0000119329"
FT   REPEAT          114..197
FT                   /note="1"
FT   REPEAT          210..291
FT                   /note="2"
FT   ZN_FING         3..34
FT                   /note="TFIIB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         7
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         10
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         26
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         29
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
SQ   SEQUENCE   300 AA;  33857 MW;  703ABE0B36411232 CRC64;
     MSGKRVCPVC GSTEFIYDPS RGEIVCKVCG YVIEENVVDE GPEWRAFDPG QREKRARVGA
     PESILLHDKG LSTDIGIDRS LTGLMREKMY RLRKWQSRLR VSDAAERNLA FALSELDRLA
     SNLSLPKHVE EEAARLYREA VRKGLIRGRS IEAVIAACVY AACRLLKVPR TLDEIADVSR
     VDKKEIGRSF RFIARHLNLT PKKLFVKPTD YVNKFADELG LSEKVRRRAI EILEEAYQRG
     LTSGKSPAGL VAAALYIASL MEGEKRTQRE VAEVARVTEV TVRNRYKELV EKLNLKVPIA