ID   TF2B2_HALSA             Reviewed;         325 AA.
AC   Q9HRE6;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Transcription initiation factor IIB 2 {ECO:0000255|HAMAP-Rule:MF_00383};
DE            Short=TFIIB 2 {ECO:0000255|HAMAP-Rule:MF_00383};
GN   Name=tfbB {ECO:0000255|HAMAP-Rule:MF_00383}; OrderedLocusNames=VNG_0734G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- FUNCTION: Stabilizes TBP binding to an archaeal box-A promoter. Also
CC       responsible for recruiting RNA polymerase II to the pre-initiation
CC       complex (DNA-TBP-TFIIB). {ECO:0000255|HAMAP-Rule:MF_00383}.
CC   -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00383}.
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DR   EMBL; AE004437; AAG19212.1; -; Genomic_DNA.
DR   PIR; H84230; H84230.
DR   RefSeq; WP_010902508.1; NC_002607.1.
DR   AlphaFoldDB; Q9HRE6; -.
DR   SMR; Q9HRE6; -.
DR   STRING; 64091.VNG_0734G; -.
DR   PaxDb; Q9HRE6; -.
DR   EnsemblBacteria; AAG19212; AAG19212; VNG_0734G.
DR   GeneID; 5952668; -.
DR   GeneID; 62886335; -.
DR   KEGG; hal:VNG_0734G; -.
DR   PATRIC; fig|64091.14.peg.561; -.
DR   HOGENOM; CLU_043736_0_0_2; -.
DR   InParanoid; Q9HRE6; -.
DR   OMA; TKMMHDK; -.
DR   OrthoDB; 35979at2157; -.
DR   PhylomeDB; Q9HRE6; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 2.
DR   HAMAP; MF_00383; TF2B_arch; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR000812; TFIIB.
DR   InterPro; IPR023484; TFIIB_arc.
DR   InterPro; IPR023486; TFIIB_CS.
DR   InterPro; IPR013150; TFIIB_cyclin.
DR   InterPro; IPR013137; Znf_TFIIB.
DR   PANTHER; PTHR11618; PTHR11618; 1.
DR   Pfam; PF08271; TF_Zn_Ribbon; 1.
DR   Pfam; PF00382; TFIIB; 2.
DR   PRINTS; PR00685; TIFACTORIIB.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00782; TFIIB; 2.
DR   PROSITE; PS51134; ZF_TFIIB; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..325
FT                   /note="Transcription initiation factor IIB 2"
FT                   /id="PRO_0000119312"
FT   REPEAT          144..227
FT                   /note="1"
FT   REPEAT          238..319
FT                   /note="2"
FT   ZN_FING         28..58
FT                   /note="TFIIB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          73..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         32
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         35
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         50
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         53
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
SQ   SEQUENCE   325 AA;  36156 MW;  32FD89E9FC792F2C CRC64;
     MSDSTIRTYS SDQRQTDNDE TVSTPDEDVL TCPECGGQVI DDEEHGESVC VDCGLVVEEN
     GIDRGPEWRA FNSTEKDEKS RVGAPTTNMM HDKGLSTNIG WQDKDAYGNS LSSNQRQKMQ
     RLRKWNERFR TRNSKERNLK QALGEIERMA SALGLPKEVR ETASVIYRRA LSEDLLPGRS
     IEGVATAALY ASARQLSTPR SIDEVANVSR IDEMEFKRTY RYIVRELSLE VAPADPAQYV
     PRFASDLDLP DEVERRSREL ISNAQADGVT SGKSPVGLAA AAIYASSLLT NHKVTQSEVS
     EVTDVSEVTI RNRYQELLEA TEAAA