ID   TF2B2_THEAC             Reviewed;         307 AA.
AC   Q9HJM2;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Transcription initiation factor IIB 2 {ECO:0000255|HAMAP-Rule:MF_00383};
DE            Short=TFIIB 2 {ECO:0000255|HAMAP-Rule:MF_00383};
GN   Name=tfbB {ECO:0000255|HAMAP-Rule:MF_00383}; OrderedLocusNames=Ta0945;
OS   Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS   15155 / AMRC-C165).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273075;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX   PubMed=11029001; DOI=10.1038/35035069;
RA   Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA   Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT   "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT   acidophilum.";
RL   Nature 407:508-513(2000).
CC   -!- FUNCTION: Stabilizes TBP binding to an archaeal box-A promoter. Also
CC       responsible for recruiting RNA polymerase II to the pre-initiation
CC       complex (DNA-TBP-TFIIB). {ECO:0000255|HAMAP-Rule:MF_00383}.
CC   -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00383}.
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DR   EMBL; AL445066; CAC12074.1; -; Genomic_DNA.
DR   RefSeq; WP_010901355.1; NC_002578.1.
DR   AlphaFoldDB; Q9HJM2; -.
DR   SMR; Q9HJM2; -.
DR   STRING; 273075.Ta0945; -.
DR   EnsemblBacteria; CAC12074; CAC12074; CAC12074.
DR   GeneID; 1456477; -.
DR   KEGG; tac:Ta0945; -.
DR   eggNOG; arCOG01981; Archaea.
DR   HOGENOM; CLU_043736_0_1_2; -.
DR   OMA; RTQKDFA; -.
DR   OrthoDB; 35979at2157; -.
DR   Proteomes; UP000001024; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 2.
DR   HAMAP; MF_00383; TF2B_arch; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR000812; TFIIB.
DR   InterPro; IPR023484; TFIIB_arc.
DR   InterPro; IPR023486; TFIIB_CS.
DR   InterPro; IPR013150; TFIIB_cyclin.
DR   InterPro; IPR013137; Znf_TFIIB.
DR   PANTHER; PTHR11618; PTHR11618; 1.
DR   Pfam; PF08271; TF_Zn_Ribbon; 1.
DR   Pfam; PF00382; TFIIB; 2.
DR   PRINTS; PR00685; TIFACTORIIB.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00782; TFIIB; 1.
DR   PROSITE; PS51134; ZF_TFIIB; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..307
FT                   /note="Transcription initiation factor IIB 2"
FT                   /id="PRO_0000119339"
FT   REPEAT          124..207
FT                   /note="1"
FT   REPEAT          218..299
FT                   /note="2"
FT   ZN_FING         7..38
FT                   /note="TFIIB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         11
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         14
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         30
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         33
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
SQ   SEQUENCE   307 AA;  34463 MW;  8C251025CBBBADD4 CRC64;
     MTVEGETPKR CPECNSEHLI RDYEHGELIC ADCGAVIEDA YIDQGPEWRA FDSDQDERRA
     RTGSPMTYLS HDKGLATEIS WSNKDYYGKR IPHKNRAQIY RVRKWHQRIR VSNAAERNLS
     LALQLLNDIG AKLGIPKDIK ETAALIYRKA VEKNLIRGRS IESIVCASIY AACRKVNIPR
     TLDEISKASE VNKKKIGKAY RHLAKELDLN LKPTTPFSYI SQFCNKLDLD KQAIVISEDI
     VRQAMSMGIS SGKGPTGIAA AAIYIASVKV GKPRTQKEIA RISGVTEVTI RNRYKEISKA
     LNISISE