ID   TF2B2_THEKO             Reviewed;         306 AA.
AC   P58109;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Transcription initiation factor IIB 2 {ECO:0000255|HAMAP-Rule:MF_00383};
DE            Short=TFIIB 2 {ECO:0000255|HAMAP-Rule:MF_00383};
GN   Name=tfb2 {ECO:0000255|HAMAP-Rule:MF_00383}; Synonyms=tfb;
GN   OrderedLocusNames=TK2287;
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=11453461; DOI=10.1007/s007920100193;
RA   Matsuda T., Fujikawa M., Haruki M., Tang X.F., Ezaki S., Imanaka T.,
RA   Morikawa M., Kanaya S.;
RT   "Interaction of TIP26 from a hyperthermophilic archaeon with TFB/TBP/DNA
RT   ternary complex.";
RL   Extremophiles 5:177-182(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT   kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL   Genome Res. 15:352-363(2005).
CC   -!- FUNCTION: Stabilizes TBP binding to an archaeal box-A promoter. Also
CC       responsible for recruiting RNA polymerase II to the pre-initiation
CC       complex (DNA-TBP-TFIIB). {ECO:0000255|HAMAP-Rule:MF_00383}.
CC   -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00383}.
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DR   EMBL; AB046423; BAB21262.1; -; Genomic_DNA.
DR   EMBL; AP006878; BAD86476.1; -; Genomic_DNA.
DR   AlphaFoldDB; P58109; -.
DR   SMR; P58109; -.
DR   STRING; 69014.TK2287; -.
DR   EnsemblBacteria; BAD86476; BAD86476; TK2287.
DR   KEGG; tko:TK2287; -.
DR   PATRIC; fig|69014.16.peg.2242; -.
DR   eggNOG; arCOG01981; Archaea.
DR   HOGENOM; CLU_043736_0_1_2; -.
DR   InParanoid; P58109; -.
DR   OMA; RMWQRRM; -.
DR   PhylomeDB; P58109; -.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0097550; C:transcription preinitiation complex; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR   GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 1.
DR   HAMAP; MF_00383; TF2B_arch; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR000812; TFIIB.
DR   InterPro; IPR023484; TFIIB_arc.
DR   InterPro; IPR023486; TFIIB_CS.
DR   InterPro; IPR013150; TFIIB_cyclin.
DR   InterPro; IPR013137; Znf_TFIIB.
DR   PANTHER; PTHR11618; PTHR11618; 1.
DR   Pfam; PF08271; TF_Zn_Ribbon; 1.
DR   Pfam; PF00382; TFIIB; 2.
DR   PRINTS; PR00685; TIFACTORIIB.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00782; TFIIB; 2.
DR   PROSITE; PS51134; ZF_TFIIB; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..306
FT                   /note="Transcription initiation factor IIB 2"
FT                   /id="PRO_0000119330"
FT   REPEAT          123..206
FT                   /note="1"
FT   REPEAT          217..298
FT                   /note="2"
FT   ZN_FING         6..37
FT                   /note="TFIIB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         10
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         13
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         29
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         32
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
SQ   SEQUENCE   306 AA;  34481 MW;  21B0DA89C5546F9D CRC64;
     MRGISPKRVC PICGSTEFIY DPRRGEIVCA KCGYVIEENV VDEGPEWRAF EPGQREKRAR
     TGAPMTLMIH DKGLSTDIDW RDKDIHGNQI TGMYRNKLRR LRMWQRRMRI NDAAERNLAF
     ALSELDRMAA QLRLPRHLKE VAASLYRKAV MKKLIRGRSI EGMVSAALYA ACRMEGIPRT
     LDEIASVSKV SKKEIGRSYR FMARGLGLNL RPTSPIEYVD RFGDALGVSA RTKKRAKEIL
     NEAIKRGITS GKGPTGLAAA ALYIAALLEG EKKTQREVAE VAHVTEVTVR NRYKELVEKL
     GINVPI