TF2B4_HALSA
ID TF2B4_HALSA Reviewed; 328 AA.
AC Q9HR45;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Transcription initiation factor IIB 4 {ECO:0000255|HAMAP-Rule:MF_00383};
DE Short=TFIIB 4 {ECO:0000255|HAMAP-Rule:MF_00383};
GN Name=tfbD {ECO:0000255|HAMAP-Rule:MF_00383}; OrderedLocusNames=VNG_0869G;
OS Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS (Halobacterium halobium).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium.
OX NCBI_TaxID=64091;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=11016950; DOI=10.1073/pnas.190337797;
RA Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA DasSarma S.;
RT "Genome sequence of Halobacterium species NRC-1.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC -!- FUNCTION: Stabilizes TBP binding to an archaeal box-A promoter. Also
CC responsible for recruiting RNA polymerase II to the pre-initiation
CC complex (DNA-TBP-TFIIB). {ECO:0000255|HAMAP-Rule:MF_00383}.
CC -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000255|HAMAP-
CC Rule:MF_00383}.
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DR EMBL; AE004437; AAG19313.1; -; Genomic_DNA.
DR PIR; E84243; E84243.
DR RefSeq; WP_010902609.1; NC_002607.1.
DR AlphaFoldDB; Q9HR45; -.
DR SMR; Q9HR45; -.
DR STRING; 64091.VNG_0869G; -.
DR PaxDb; Q9HR45; -.
DR EnsemblBacteria; AAG19313; AAG19313; VNG_0869G.
DR GeneID; 5952730; -.
DR GeneID; 62886439; -.
DR KEGG; hal:VNG_0869G; -.
DR PATRIC; fig|64091.14.peg.666; -.
DR HOGENOM; CLU_043736_0_1_2; -.
DR InParanoid; Q9HR45; -.
DR OMA; SDEQEHC; -.
DR OrthoDB; 35979at2157; -.
DR PhylomeDB; Q9HR45; -.
DR Proteomes; UP000000554; Chromosome.
DR GO; GO:0097550; C:transcription preinitiation complex; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro.
DR CDD; cd00043; CYCLIN; 1.
DR HAMAP; MF_00383; TF2B_arch; 1.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR000812; TFIIB.
DR InterPro; IPR023484; TFIIB_arc.
DR InterPro; IPR023486; TFIIB_CS.
DR InterPro; IPR013150; TFIIB_cyclin.
DR InterPro; IPR013137; Znf_TFIIB.
DR PANTHER; PTHR11618; PTHR11618; 1.
DR Pfam; PF08271; TF_Zn_Ribbon; 1.
DR Pfam; PF00382; TFIIB; 2.
DR PRINTS; PR00685; TIFACTORIIB.
DR SMART; SM00385; CYCLIN; 2.
DR SUPFAM; SSF47954; SSF47954; 2.
DR PROSITE; PS00782; TFIIB; 2.
DR PROSITE; PS51134; ZF_TFIIB; 1.
PE 3: Inferred from homology;
KW Metal-binding; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..328
FT /note="Transcription initiation factor IIB 4"
FT /id="PRO_0000119314"
FT REPEAT 144..227
FT /note="1"
FT REPEAT 238..319
FT /note="2"
FT ZN_FING 28..58
FT /note="TFIIB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 32
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT BINDING 35
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT BINDING 50
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT BINDING 53
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
SQ SEQUENCE 328 AA; 35932 MW; F7DB4A716C3B8AA4 CRC64;
MTNQRTTRDG SHGTESVPTQ RSRESTDEDH GCPECNGDLV TDEDRGETTC GECGLVVEED
GIDHGPEWRA FNAQEQDEKS RVGAPTTNMM HDKGLSTNIG WQDKDAYGNT LSGRQRRKMQ
RLRKWNERFR TRNSKERNLK QALGEIERMA SAFGLPDSVR ETASVIYRRA LGEDLLPGRS
IEGVATSALY AAARQANTPR SLDEVASVSR VDRGEIARTY RYVARELSLE VAPTDPASYV
PRFCSDLELS GDVERRARDL LAAAADAGIT SGKSPVGLAA ASVYAAALLT NERVTQNEVS
TVANVSEVTI RNRYHEILDA GGEPGVEA
