TF2B5_HALSA
ID TF2B5_HALSA Reviewed; 307 AA.
AC Q9HHH8;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Transcription initiation factor IIB 5 {ECO:0000255|HAMAP-Rule:MF_00383};
DE Short=TFIIB 5 {ECO:0000255|HAMAP-Rule:MF_00383};
GN Name=tfbE {ECO:0000255|HAMAP-Rule:MF_00383}; OrderedLocusNames=VNG_6389G;
OS Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS (Halobacterium halobium).
OG Plasmid pNRC200.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium.
OX NCBI_TaxID=64091;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=11016950; DOI=10.1073/pnas.190337797;
RA Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA DasSarma S.;
RT "Genome sequence of Halobacterium species NRC-1.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC -!- FUNCTION: Stabilizes TBP binding to an archaeal box-A promoter. Also
CC responsible for recruiting RNA polymerase II to the pre-initiation
CC complex (DNA-TBP-TFIIB). {ECO:0000255|HAMAP-Rule:MF_00383}.
CC -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000255|HAMAP-
CC Rule:MF_00383}.
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DR EMBL; AE004438; AAG21002.1; -; Genomic_DNA.
DR RefSeq; WP_010904212.1; NZ_BK010831.1.
DR AlphaFoldDB; Q9HHH8; -.
DR SMR; Q9HHH8; -.
DR EnsemblBacteria; AAG21002; AAG21002; VNG_6389G.
DR GeneID; 5955039; -.
DR KEGG; hal:VNG_6389G; -.
DR PATRIC; fig|64091.14.peg.2339; -.
DR HOGENOM; CLU_043736_0_0_2; -.
DR InParanoid; Q9HHH8; -.
DR OMA; NEYVCTR; -.
DR OrthoDB; 35979at2157; -.
DR PhylomeDB; Q9HHH8; -.
DR Proteomes; UP000000554; Plasmid pNRC200.
DR GO; GO:0097550; C:transcription preinitiation complex; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro.
DR CDD; cd00043; CYCLIN; 2.
DR HAMAP; MF_00383; TF2B_arch; 1.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR000812; TFIIB.
DR InterPro; IPR023484; TFIIB_arc.
DR InterPro; IPR013150; TFIIB_cyclin.
DR InterPro; IPR013137; Znf_TFIIB.
DR PANTHER; PTHR11618; PTHR11618; 1.
DR Pfam; PF08271; TF_Zn_Ribbon; 1.
DR Pfam; PF00382; TFIIB; 2.
DR PRINTS; PR00685; TIFACTORIIB.
DR SMART; SM00385; CYCLIN; 2.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 3: Inferred from homology;
KW Metal-binding; Plasmid; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..307
FT /note="Transcription initiation factor IIB 5"
FT /id="PRO_0000119315"
FT REPEAT 129..212
FT /note="1"
FT REPEAT 223..304
FT /note="2"
FT ZN_FING 19..47
FT /note="TFIIB-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00383"
FT REGION 54..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 23
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00383"
FT BINDING 26
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00383"
FT BINDING 39
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00383"
FT BINDING 42
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00383"
SQ SEQUENCE 307 AA; 33264 MW; F4C767B22EAFC1A1 CRC64;
MTTSEPYERA FDEDIQRGTT EPCPECGGPV RTNSAETVCA DCGLIIDEQS IDRGPEWHRD
DADTAKRTGA PLTPARHDRG LSTVIGSGQD ARGTALSSEK RRRLARMRRE QSRGRWRSTK
ERNLGHGLTE IRRIASALGL ADSVRDQACQ LFRTAQNERL LKGRSIEAMA AASVFGACRC
NGESWLIDDV APMAQVGQNR VENAYTVLNE ELGLPTPPVS LDQFVPRLAS DLGCTDVVRR
RAEELVVQAV DAGITTGVHP SGFAAACLYM AACVHDAPLT QADAAAAAGV TVETIRSHRD
RLLSIVE
