ID   TF2B7_HALSA             Reviewed;         323 AA.
AC   Q9HSF7;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Transcription initiation factor IIB 7 {ECO:0000255|HAMAP-Rule:MF_00383};
DE            Short=TFIIB 7 {ECO:0000255|HAMAP-Rule:MF_00383};
GN   Name=tfbG {ECO:0000255|HAMAP-Rule:MF_00383}; OrderedLocusNames=VNG_0254G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- FUNCTION: Stabilizes TBP binding to an archaeal box-A promoter. Also
CC       responsible for recruiting RNA polymerase II to the pre-initiation
CC       complex (DNA-TBP-TFIIB). {ECO:0000255|HAMAP-Rule:MF_00383}.
CC   -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00383}.
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DR   EMBL; AE004437; AAG18850.1; -; Genomic_DNA.
DR   PIR; F84185; F84185.
DR   RefSeq; WP_010902144.1; NC_002607.1.
DR   AlphaFoldDB; Q9HSF7; -.
DR   SMR; Q9HSF7; -.
DR   STRING; 64091.VNG_0254G; -.
DR   PaxDb; Q9HSF7; -.
DR   EnsemblBacteria; AAG18850; AAG18850; VNG_0254G.
DR   GeneID; 5952444; -.
DR   GeneID; 62885961; -.
DR   KEGG; hal:VNG_0254G; -.
DR   PATRIC; fig|64091.14.peg.186; -.
DR   HOGENOM; CLU_043736_0_0_2; -.
DR   InParanoid; Q9HSF7; -.
DR   OMA; DHDQRMK; -.
DR   OrthoDB; 35979at2157; -.
DR   PhylomeDB; Q9HSF7; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0097550; C:transcription preinitiation complex; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR   GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 2.
DR   HAMAP; MF_00383; TF2B_arch; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR000812; TFIIB.
DR   InterPro; IPR023484; TFIIB_arc.
DR   InterPro; IPR023486; TFIIB_CS.
DR   InterPro; IPR013150; TFIIB_cyclin.
DR   InterPro; IPR013137; Znf_TFIIB.
DR   PANTHER; PTHR11618; PTHR11618; 1.
DR   Pfam; PF08271; TF_Zn_Ribbon; 1.
DR   Pfam; PF00382; TFIIB; 2.
DR   PRINTS; PR00685; TIFACTORIIB.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00782; TFIIB; 2.
DR   PROSITE; PS51134; ZF_TFIIB; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..323
FT                   /note="Transcription initiation factor IIB 7"
FT                   /id="PRO_0000119317"
FT   REPEAT          142..225
FT                   /note="1"
FT   REPEAT          236..317
FT                   /note="2"
FT   ZN_FING         24..56
FT                   /note="TFIIB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         29
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         32
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         48
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         51
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
SQ   SEQUENCE   323 AA;  36630 MW;  525B3D42B2CA4FEE CRC64;
     MTRSTRQRER ETAAKQEEEE DSEEGVRECP ECGSDNLVKS SDRAELVCND CGLVVEEEQI
     DPGPEWRAFN HQERQEKSRV GAPTTQTMHD KGLTTTIDWK DKDAYGRSIS SKKRSQMHRL
     RKWQERIRTK DAGERNLQFA LSEIDRMASA LGVPRSVREV ASVIYRRALK EDLIRGRSIE
     GVATSALYAA CRKEGIPRSL EEISEVSRVE RKEIGRTYRY ISQELGLEMK PVDPKKYVPR
     FCSELELTEE VQSKANEIIE TTAEEGLLSG KSPTGYAAAA IYAASLLCNE KKTQREVADV
     AQVTEVTIRN RYQEQIEAMG IHG