ID   TF2B_AERPE              Reviewed;         322 AA.
AC   Q9Y942;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 2.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Transcription initiation factor IIB {ECO:0000255|HAMAP-Rule:MF_00383};
DE            Short=TFIIB {ECO:0000255|HAMAP-Rule:MF_00383};
GN   Name=tfb {ECO:0000255|HAMAP-Rule:MF_00383}; OrderedLocusNames=APE_2443.1;
OS   Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS   K1).
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=272557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX   PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA   Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA   Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA   Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT   "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT   Aeropyrum pernix K1.";
RL   DNA Res. 6:83-101(1999).
CC   -!- FUNCTION: Stabilizes TBP binding to an archaeal box-A promoter. Also
CC       responsible for recruiting RNA polymerase II to the pre-initiation
CC       complex (DNA-TBP-TFIIB). {ECO:0000255|HAMAP-Rule:MF_00383}.
CC   -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00383}.
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DR   EMBL; BA000002; BAA81458.2; -; Genomic_DNA.
DR   PIR; B72475; B72475.
DR   AlphaFoldDB; Q9Y942; -.
DR   SMR; Q9Y942; -.
DR   STRING; 272557.APE_2443.1; -.
DR   EnsemblBacteria; BAA81458; BAA81458; APE_2443.1.
DR   KEGG; ape:APE_2443.1; -.
DR   PATRIC; fig|272557.25.peg.1622; -.
DR   eggNOG; arCOG01981; Archaea.
DR   Proteomes; UP000002518; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR   GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 2.
DR   HAMAP; MF_00383; TF2B_arch; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR000812; TFIIB.
DR   InterPro; IPR023484; TFIIB_arc.
DR   InterPro; IPR023486; TFIIB_CS.
DR   InterPro; IPR013150; TFIIB_cyclin.
DR   PANTHER; PTHR11618; PTHR11618; 1.
DR   Pfam; PF00382; TFIIB; 2.
DR   PRINTS; PR00685; TIFACTORIIB.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00782; TFIIB; 2.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..322
FT                   /note="Transcription initiation factor IIB"
FT                   /id="PRO_0000119309"
FT   REPEAT          125..213
FT                   /note="1"
FT   REPEAT          224..305
FT                   /note="2"
SQ   SEQUENCE   322 AA;  35377 MW;  49719F9B7FA4E9CF CRC64;
     MASEIPYDES PSGEESGEIK CKNIVTDPVR GLKICADTGE IIGEDIIGTE SDVKAYTPEE
     RQQKTHYGGP LKYSHHYMGV EASLEHPRDH GPKGIKQRKI LPRRPPRLSA RPLTSVDKNL
     QTALSLINEV ASRMGMPEIV VEDASKIYRE AMEKGLTRGR SIESIVAASL YAASRIHGLP
     HSLTDIIKAM KGNVDAETRR DVARSYRLLV RDLNIKIPVR KPENFVYTII SALGLPEHVA
     IEAIKIIDLS RKKGLTAGKD PGGLAGAAVY LAALKHGIRK TQKEIAHVVG VTEVTIRNRY
     KEIAQALGIE EELEEKGGEE KG