ID   TF2B_DROVI              Reviewed;         293 AA.
AC   Q9NHP7;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Transcription initiation factor IIB;
DE   AltName: Full=General transcription factor TFIIB;
GN   Name=TfIIB;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Oh Y., Baek K., Yoon J.;
RT   "Structure of Drosophila virilis TBP and TFIIB genes and comparison with
RT   the Drosophila melanogaster genes.";
RL   Korean J. Genet. 21:299-305(1999).
CC   -!- FUNCTION: General factor that plays a major role in the activation of
CC       eukaryotic genes transcribed by RNA polymerase II. {ECO:0000250}.
CC   -!- SUBUNIT: Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB
CC       (DAB-complex) which is then recognized by polymerase II. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000305}.
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DR   EMBL; AF220260; AAF71709.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9NHP7; -.
DR   SMR; Q9NHP7; -.
DR   eggNOG; KOG1597; Eukaryota.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR   GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 2.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR000812; TFIIB.
DR   InterPro; IPR023486; TFIIB_CS.
DR   InterPro; IPR013150; TFIIB_cyclin.
DR   InterPro; IPR013137; Znf_TFIIB.
DR   PANTHER; PTHR11618; PTHR11618; 1.
DR   Pfam; PF00382; TFIIB; 2.
DR   PRINTS; PR00685; TIFACTORIIB.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00782; TFIIB; 2.
DR   PROSITE; PS51134; ZF_TFIIB; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Nucleus; Repeat; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..293
FT                   /note="Transcription initiation factor IIB"
FT                   /id="PRO_0000119300"
FT   REPEAT          101..177
FT                   /note="1"
FT   REPEAT          195..271
FT                   /note="2"
FT   ZN_FING         10..41
FT                   /note="TFIIB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         14
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         17
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         33
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
FT   BINDING         36
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00469"
SQ   SEQUENCE   293 AA;  31946 MW;  741C8304EEE8A63B CRC64;
     MASTSRLENN KVCCYAHPES PLIEDYRAGD MICSECGLVV GDAFGGPENP LLSGGHLSTI
     IGPGTGSASF DAFGAPKYPN RRTMRSSDRS LISAFKEISS MADRINLPKT IVDRANTLFK
     QVHDGKNLKG RSNDAKASAC LYIACRQEGV PRTFKEICAV SKISKKEIGR CFKLTLKALE
     TSVDLITTAD FMCRFCANLD LPNMVQRAAT HIAKKAVEMD IVPGRSPISV AAAAIYMASQ
     ASEHKRSQKE IGDIAGVADV TIRQSYKLMY PHAAKLFPED FKFTTPIDQL PQM