ID   TF2B_PYROC              Reviewed;         310 AA.
AC   Q977X4;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Transcription initiation factor IIB {ECO:0000255|HAMAP-Rule:MF_00383};
DE            Short=TFIIB {ECO:0000255|HAMAP-Rule:MF_00383};
GN   Name=tfb {ECO:0000255|HAMAP-Rule:MF_00383};
OS   Pyrodictium occultum.
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales; Pyrodictiaceae;
OC   Pyrodictium.
OX   NCBI_TaxID=2309;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PL 19;
RA   Lindner P., Frey G., Stetter K.O.;
RT   "Characterization of transcription factors in the hyperthermophilic
RT   archaeon Pyrodictium occultum.";
RL   Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stabilizes TBP binding to an archaeal box-A promoter. Also
CC       responsible for recruiting RNA polymerase II to the pre-initiation
CC       complex (DNA-TBP-TFIIB). {ECO:0000255|HAMAP-Rule:MF_00383}.
CC   -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00383}.
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DR   EMBL; AF367982; AAK38724.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q977X4; -.
DR   SMR; Q977X4; -.
DR   STRING; 2309.CF15_03000; -.
DR   PRIDE; Q977X4; -.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR   GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 1.
DR   HAMAP; MF_00383; TF2B_arch; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR000812; TFIIB.
DR   InterPro; IPR023484; TFIIB_arc.
DR   InterPro; IPR023486; TFIIB_CS.
DR   InterPro; IPR013150; TFIIB_cyclin.
DR   InterPro; IPR013137; Znf_TFIIB.
DR   PANTHER; PTHR11618; PTHR11618; 1.
DR   Pfam; PF08271; TF_Zn_Ribbon; 1.
DR   Pfam; PF00382; TFIIB; 2.
DR   PRINTS; PR00685; TIFACTORIIB.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00782; TFIIB; 2.
PE   3: Inferred from homology;
KW   Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..310
FT                   /note="Transcription initiation factor IIB"
FT                   /id="PRO_0000119331"
FT   REPEAT          126..209
FT                   /note="1"
FT   REPEAT          220..301
FT                   /note="2"
SQ   SEQUENCE   310 AA;  34491 MW;  CD8613F632AF6216 CRC64;
     MTKEQAPRAS GEKEEGCPPE YIVFDEERGE YICTLTGEVV EETVIDTGPE WRAYTPEERT
     RRSRVGSPLT HTLPDYGILT TISGYRDANG RKLEARLRIE ASRLRRLQAK LRATTSIEKN
     IEQAAREITR LVEALNLPRG IIDTAMMIYR QAAEKGLVRG RSLESMAAAA VYAACRIRGI
     PRSIDDIAEV VKGGRKEVAR CYRLIVRELK LRMPIVDPVR YVSRIVSALR LSPAVERRAA
     EILVQARKMG LTAGKDPAGL AAAAIYIAAL ELGERRTQKE IAAAAGVTEV TVRNRYKELV
     QKLNIPLPAQ