ID   TF2B_SACSH              Reviewed;         309 AA.
AC   P50387;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Transcription initiation factor IIB {ECO:0000255|HAMAP-Rule:MF_00383};
DE            Short=TFIIB {ECO:0000255|HAMAP-Rule:MF_00383};
GN   Name=tfb {ECO:0000255|HAMAP-Rule:MF_00383};
OS   Saccharolobus shibatae (Sulfolobus shibatae).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Saccharolobus.
OX   NCBI_TaxID=2286;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7597084; DOI=10.1073/pnas.92.13.6077;
RA   Qureshi S.A., Khoo B., Baumann P., Jackson S.P.;
RT   "Molecular cloning of the transcription factor TFIIB homolog from
RT   Sulfolobus shibatae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:6077-6081(1995).
CC   -!- FUNCTION: Stabilizes TBP binding to an archaeal box-A promoter. Also
CC       responsible for recruiting RNA polymerase II to the pre-initiation
CC       complex (DNA-TBP-TFIIB). {ECO:0000255|HAMAP-Rule:MF_00383}.
CC   -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00383}.
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DR   EMBL; U20899; AAA81380.1; -; Genomic_DNA.
DR   PIR; T46894; T46894.
DR   AlphaFoldDB; P50387; -.
DR   SMR; P50387; -.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR   GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 2.
DR   HAMAP; MF_00383; TF2B_arch; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR000812; TFIIB.
DR   InterPro; IPR023484; TFIIB_arc.
DR   InterPro; IPR023486; TFIIB_CS.
DR   InterPro; IPR013150; TFIIB_cyclin.
DR   InterPro; IPR013137; Znf_TFIIB.
DR   PANTHER; PTHR11618; PTHR11618; 1.
DR   Pfam; PF08271; TF_Zn_Ribbon; 1.
DR   Pfam; PF00382; TFIIB; 2.
DR   PRINTS; PR00685; TIFACTORIIB.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00782; TFIIB; 2.
PE   3: Inferred from homology;
KW   Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..309
FT                   /note="Transcription initiation factor IIB"
FT                   /id="PRO_0000119334"
FT   REPEAT          125..208
FT                   /note="1"
FT   REPEAT          219..300
FT                   /note="2"
SQ   SEQUENCE   309 AA;  34756 MW;  FFAD89C82C1B5FC8 CRC64;
     MLYLSEENKS VSTPCPPDKI IFDAERGEYI CSETGEVLED KIIDQGPEWR AFTPEEKEKR
     SRVGGPLNNT IHDRGLSTLI DWKDKDAMGR TLDPKRRLEA LRWRKWQIRA RIQSSIDRNL
     AQAMNELERI GNLLNLPKSV KDEAALIYRK AVEKGLVRGR SIESVVAAAI YAACRRMKLA
     RTLDEIAQYT KANRKEVARC YRLLLRELDV SVPVSDPKDY VTRIANLLGL SGRVMKTAAE
     IIDKAKGSGL TAGKDPAGLA AAAIYIASLL HDERRTQKEI AQVAGVTEVT VRNRYKELTQ
     ELKISIPTQ