ID   TF2B_SULAC              Reviewed;         307 AA.
AC   Q9UWN6; Q4JAE6;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 2.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Transcription initiation factor IIB {ECO:0000255|HAMAP-Rule:MF_00383};
DE            Short=TFIIB {ECO:0000255|HAMAP-Rule:MF_00383};
GN   Name=tfb {ECO:0000255|HAMAP-Rule:MF_00383}; Synonyms=tifB;
GN   OrderedLocusNames=Saci_0866;
OS   Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC
OS   15157 / NCIMB 11770).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=330779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10777593; DOI=10.1074/jbc.275.17.12934;
RA   Bell S.D., Jackson S.P.;
RT   "The role of transcription factor B in transcription initiation and
RT   promoter clearance in the archaeon Sulfolobus acidocaldarius.";
RL   J. Biol. Chem. 275:12934-12940(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX   PubMed=15995215; DOI=10.1128/jb.187.14.4992-4999.2005;
RA   Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E.,
RA   Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.;
RT   "The genome of Sulfolobus acidocaldarius, a model organism of the
RT   Crenarchaeota.";
RL   J. Bacteriol. 187:4992-4999(2005).
CC   -!- FUNCTION: Stabilizes TBP binding to an archaeal box-A promoter. Also
CC       responsible for recruiting RNA polymerase II to the pre-initiation
CC       complex (DNA-TBP-TFIIB). {ECO:0000255|HAMAP-Rule:MF_00383}.
CC   -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00383}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAY80233.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF205429; AAF18139.1; -; Genomic_DNA.
DR   EMBL; CP000077; AAY80233.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_024083452.1; NC_007181.1.
DR   AlphaFoldDB; Q9UWN6; -.
DR   SMR; Q9UWN6; -.
DR   STRING; 330779.Saci_0866; -.
DR   EnsemblBacteria; AAY80233; AAY80233; Saci_0866.
DR   GeneID; 3472737; -.
DR   KEGG; sai:Saci_0866; -.
DR   PATRIC; fig|330779.12.peg.829; -.
DR   eggNOG; arCOG01981; Archaea.
DR   HOGENOM; CLU_043736_0_1_2; -.
DR   Proteomes; UP000001018; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR   GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 1.
DR   HAMAP; MF_00383; TF2B_arch; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR000812; TFIIB.
DR   InterPro; IPR023484; TFIIB_arc.
DR   InterPro; IPR023486; TFIIB_CS.
DR   InterPro; IPR013150; TFIIB_cyclin.
DR   InterPro; IPR013137; Znf_TFIIB.
DR   PANTHER; PTHR11618; PTHR11618; 1.
DR   Pfam; PF08271; TF_Zn_Ribbon; 1.
DR   Pfam; PF00382; TFIIB; 2.
DR   PRINTS; PR00685; TIFACTORIIB.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00782; TFIIB; 2.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..307
FT                   /note="Transcription initiation factor IIB"
FT                   /id="PRO_0000119333"
FT   REPEAT          123..206
FT                   /note="1"
FT   REPEAT          217..298
FT                   /note="2"
FT   CONFLICT        307
FT                   /note="Q -> QLE (in Ref. 1; AAF18139)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   307 AA;  34698 MW;  86F2B64A29B8A8B0 CRC64;
     MVEQSKVPSS SLCPPDKIIF DEERGEYICT ETGEVIEERI IDQGPEWRAF TPEEKEKRSR
     VGGPLNQTIH DMGISTVIDW KDKDAMGRSL DPKRRLEVLR WRKWQIRTRI QSSIDRNLAQ
     AMNELERIGN LLNLPKAVKD EAALIYRKAV EKGLVRGRSI ESVVAASIYA ACRRMKMART
     LDEIAQFTKA NRKEVARCYR LILRELDIEV PVSDPKDYVT RIGTLLSLSG ITMKHAAEII
     EKAKNSGLTA GKDPAGLAAA AIYIAALLND ERRTQKEIAQ VAGVTEVTVR NRYKELTQEL
     KIQIPSQ