ID   TF2H3_BOVIN             Reviewed;         309 AA.
AC   Q05B56;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=General transcription factor IIH subunit 3;
DE   AltName: Full=General transcription factor IIH polypeptide 3;
GN   Name=GTF2H3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the general transcription and DNA repair factor
CC       IIH (TFIIH) core complex, which is involved in general and
CC       transcription-coupled nucleotide excision repair (NER) of damaged DNA
CC       and, when complexed to CAK, in RNA transcription by RNA polymerase II.
CC       In NER, TFIIH acts by opening DNA around the lesion to allow the
CC       excision of the damaged oligonucleotide and its replacement by a new
CC       DNA fragment. In transcription, TFIIH has an essential role in
CC       transcription initiation. When the pre-initiation complex (PIC) has
CC       been established, TFIIH is required for promoter opening and promoter
CC       escape. Phosphorylation of the C-terminal tail (CTD) of the largest
CC       subunit of RNA polymerase II by the kinase module CAK controls the
CC       initiation of transcription. {ECO:0000250|UniProtKB:Q13889}.
CC   -!- SUBUNIT: Part of a TFIID-containing RNA polymerase II pre-initiation
CC       complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1,
CC       GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2,
CC       ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10,
CC       TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex
CC       composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and
CC       GTF2H5, which is active in NER. The core complex associates with the 3-
CC       subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H,
CC       CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in
CC       transcription (By similarity). Interacts with RARA; the interaction
CC       requires prior phosphorylation of RARA on 'Ser-369' which then enhances
CC       interaction of RARA with CDK7 (By similarity).
CC       {ECO:0000250|UniProtKB:Q13889, ECO:0000250|UniProtKB:Q8VD76}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13889}.
CC   -!- SIMILARITY: Belongs to the TFB4 family. {ECO:0000305}.
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DR   EMBL; BC122792; AAI22793.1; -; mRNA.
DR   RefSeq; NP_001073057.1; NM_001079589.1.
DR   AlphaFoldDB; Q05B56; -.
DR   SMR; Q05B56; -.
DR   STRING; 9913.ENSBTAP00000009561; -.
DR   PaxDb; Q05B56; -.
DR   Ensembl; ENSBTAT00000009561; ENSBTAP00000009561; ENSBTAG00000007270.
DR   GeneID; 511896; -.
DR   KEGG; bta:511896; -.
DR   CTD; 2967; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007270; -.
DR   VGNC; VGNC:29696; GTF2H3.
DR   eggNOG; KOG2487; Eukaryota.
DR   GeneTree; ENSGT00390000013143; -.
DR   HOGENOM; CLU_040211_1_0_1; -.
DR   InParanoid; Q05B56; -.
DR   OMA; CFCHRKV; -.
DR   OrthoDB; 1220881at2759; -.
DR   Proteomes; UP000009136; Chromosome 17.
DR   Bgee; ENSBTAG00000007270; Expressed in oocyte and 108 other tissues.
DR   ExpressionAtlas; Q05B56; baseline and differential.
DR   GO; GO:0000438; C:core TFIIH complex portion of holo TFIIH complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005669; C:transcription factor TFIID complex; IEA:Ensembl.
DR   GO; GO:0000439; C:transcription factor TFIIH core complex; IBA:GO_Central.
DR   GO; GO:0005675; C:transcription factor TFIIH holo complex; ISS:UniProtKB.
DR   GO; GO:0097550; C:transcription preinitiation complex; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0047485; F:protein N-terminus binding; IEA:Ensembl.
DR   GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IEA:Ensembl.
DR   GO; GO:0006289; P:nucleotide-excision repair; IBA:GO_Central.
DR   GO; GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; IBA:GO_Central.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR004600; TFIIH_Tfb4/GTF2H3.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR12831; PTHR12831; 1.
DR   Pfam; PF03850; Tfb4; 1.
DR   TIGRFAMs; TIGR00627; tfb4; 1.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA repair; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..309
FT                   /note="General transcription factor IIH subunit 3"
FT                   /id="PRO_0000329321"
FT   ZN_FING         269..286
FT                   /note="C4-type"
SQ   SEQUENCE   309 AA;  34491 MW;  0D4A3BCB14EA5056 CRC64;
     MVSDEDELNL LVIIVDTNPI WWGKQALKES QFTLSKCIDA VMVLGNSHLF MNRSNKLAVI
     ASHIQESRFL YPGKNGRLGD FFGDPGNPSS EFTPSGSKDG KYELLTAANE VIAEEIKDLM
     TKSDIEGQHT ETLLAGSLAK ALCYIHRMNK EVKDNQEMKS RILVIKAAED SALQYMNFMN
     VIFAAQKQNI LIDACVLDSD SGLLQQACDI TGGLYLKVPQ MPSLLQYLLW VFLPDQDQRS
     QLILPPPVHV DYRAACFCHR NLIEIGYVCS VCLSIFCNFS PICTTCETAF KISLPPVLKA
     KKKKLKMSS